| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on nitrite production |
Griess |
0.25 µM |
BMDM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on MHC expression |
Flow cytometry |
0.25 µM |
DCs |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on MHC expression |
Flow cytometry |
0.50 µM |
DCs |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
25.00 mg/kg |
CD4+T |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
50.00 mg/kg |
CD4+T |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell proliferation |
Flow cytometry |
100.00 mg/kg |
CD4+T |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
RBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
RBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
WBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
WBC |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
NEU |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
NEU |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
LYM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
LYM |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
25.00 mg/kg |
MONO |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on hematologic parameters |
HEMAVET |
50.00 mg/kg |
MONO |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Immunization |
25.00 mg/kg |
|
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
STAT4 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Quantitative RT-PCR |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on PLP-induced Relapsing-Remitting EAE Disease |
Western Blot |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on PLP-induced Relapsing-Remitting EAE Disease |
Western Blot |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on PLP-induced Relapsing-Remitting EAE Disease |
Quantitative RT-PCR |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on PLP-induced Relapsing-Remitting EAE Disease |
Quantitative RT-PCR |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on PLP-induced Relapsing-Remitting EAE Disease |
Quantitative RT-PCR |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on the Priming and Expansion Phases of EAE |
Immunization |
25.00 mg/kg |
spinal cord |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
RD |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
Rh41 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
Rh18 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
Rh30 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
BT-12 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
CHLA-266 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
TC-71 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
CHLA-9 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
CHLA-10 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell viability |
DIMSCAN |
N/A nM |
CHLA-258 |
Homo sapiens |
|
|
|
