| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
100.00 nM |
PC-3 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
300.00 nM |
PC-3 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
1000.00 nM |
PC-3 |
Homo sapiens |
|
STAT5A |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
3.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
10.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
30.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
100.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
300.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on transcriptional activity of protein |
Luciferase Reporter Gene Assay |
1000.00 nM |
PC-3 |
Homo sapiens |
|
STAT5B |
|
| AZD1480 |
Influence on cell proliferation |
MTS Assay |
1.00 µM |
CWR22Rv1 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell proliferation |
MTS Assay |
1.00 µM |
CWR22Pc |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell proliferation |
MTS Assay |
1.00 µM |
PC-3 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell proliferation |
MTS Assay |
1.00 µM |
DU145 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell apoptosis |
FACS |
0.50 µM |
CWR22Pc |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell apoptosis |
FACS |
1.00 µM |
CWR22Pc |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell apoptosis |
FACS |
1.50 µM |
CWR22Pc |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell apoptosis |
Fluorometric immunosorbent enzyme assay |
800.00 nM |
CWR22Rv1 |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell apoptosis |
Fluorometric immunosorbent enzyme assay |
800.00 nM |
CWR22Pc |
Homo sapiens |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
10.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
30.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
10.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumour volume |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Rv1 |
Mus musculus |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Immunohistochemistry |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
STAT5A |
|
| AZD1480 |
Influence on protein activity |
Immunohistochemistry |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
STAT5B |
|
| AZD1480 |
Influence on protein activity |
Immunoprecipitation |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell proliferation |
Hematoxylin-eosin staining |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
30.00 mg/kg |
CWR22Pc |
Mus musculus |
|
|
|
| AZD1480 |
Influence on cell differentiation |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on cell differentiation |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT4 |
|
| AZD1480 |
Influence on cytokine secretion |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on cytokine secretion |
RT-qPCR |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Flow cytometry |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
|
Quantitative RT-PCR |
0.25 µM |
Th1 |
Mus musculus |
c57BL/6 |
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT1 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
2.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
4.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.25 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT5 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT5 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
0.50 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
| AZD1480 |
Influence on protein activity in presence of IL-6 |
Western Blot |
1.00 µM |
BMDM |
Mus musculus |
c57BL/6 |
STAT3 |
|
