| STAT3-IN-1 (compound 7d) |
Influence on cell proliferation |
Colony formation assay |
10.00 µM |
MDA-MB-231 |
Homo sapiens |
|
|
|
| STAT3-IN-1 (compound 7d) |
Influence on tumor growth |
Mice body weight |
10.00 mg/kg |
MDA-MB-231(xenograft) |
Mus musculus |
|
|
|
| STAT3-IN-1 (compound 7d) |
Influence on tumor growth |
Mice body weight |
20.00 mg/kg |
MDA-MB-231(xenograft) |
Mus musculus |
|
|
|
| STAT3-IN-1 (compound 7d) |
Influence on protein activity in tumor tissue |
Western Blot |
10.00 mg/kg |
MDA-MB-231(xenograft) |
Mus musculus |
|
p-STAT3(Y705) |
|
| STAT3-IN-1 (compound 7d) |
Influence on protein activity in tumor tissue |
Western Blot |
20.00 mg/kg |
MDA-MB-231(xenograft) |
Mus musculus |
|
p-STAT3(Y705) |
|
| STAT3-IN-1 (compound 7d) |
Influence on protein activity in tumor tissue |
Western Blot |
10.00 mg/kg |
MDA-MB-231(xenograft) |
Mus musculus |
|
STAT3 |
|
| STAT3-IN-1 (compound 7d) |
Influence on protein activity in tumor tissue |
Western Blot |
20.00 mg/kg |
MDA-MB-231(xenograft) |
Mus musculus |
|
STAT3 |
|
| STAT3-IN-1 (compound 7d) |
Influence on protein activity in tumor tissue |
Western Blot |
10.00 mg/kg |
MDA-MB-231(xenograft) |
Mus musculus |
|
|
|
| STAT3-IN-1 (compound 7d) |
Influence on protein activity in tumor tissue |
Western Blot |
20.00 mg/kg |
MDA-MB-231(xenograft) |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on neurons |
Immunohistochemistry |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on protein activity |
Western Blot |
10.00 mg/kg |
NeuN |
Mus musculus |
|
p-STAT3 |
|
| Ginkgolic Acid |
Influence on protein activity |
Western Blot |
10.00 mg/kg |
NeuN |
Mus musculus |
|
STAT3 |
|
| Ginkgolic Acid |
Influence on protein activity |
Western Blot |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on protein activity |
Western Blot |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on proinflammatory mediators expression |
Immunohistochemistry |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on proinflammatory mediators expression |
Immunohistochemistry |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on proinflammatory mediators expression |
Immunohistochemistry |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on proinflammatory mediators expression |
Immunohistochemistry |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on proinflammatory mediators expression |
Immunohistochemistry |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Ginkgolic Acid |
Influence on proinflammatory mediators expression |
Immunohistochemistry |
10.00 mg/kg |
NeuN |
Mus musculus |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
5.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
10.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
20.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
30.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
40.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
50.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
60.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
70.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
80.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
30.00 µM |
PBMC |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on cell viability |
MTT |
50.00 µM |
PBMC |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
30.00 µM |
U266 |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| Niclosamide |
Influence on protein activity |
Western Blot |
30.00 µM |
PBMC |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
PBMC |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| Niclosamide |
Influence on protein activity |
Western Blot |
30.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
| Niclosamide |
Influence on protein activity |
Western Blot |
30.00 µM |
PBMC |
Homo sapiens |
|
STAT3 |
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
PBMC |
Homo sapiens |
|
STAT3 |
|
| Niclosamide |
Influence on protein activity |
Western Blot |
30.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
30.00 µM |
PBMC |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
PBMC |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity |
Western Blot |
50.00 µM |
U266 |
Homo sapiens |
|
|
|
| Niclosamide |
Influence on protein activity in presence of IL-6 |
Western Blot |
50.00 µM |
MM1.S |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
