STAT3-IN-1 (compound 7d)

Name Value
Weight 475.530 g/mol
Zinc ID ZINC1772645501
Smiles COc1cc(/C=C/c2ccc(NC(=O)/C=C/c3cc(OC)c(OC)c(OC)c3)cc2)cc(OC)c1
Molecular formula C28H29NO6
Mode of inhibition N/A
CAS 2059952-75-7

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein. European journal of medicinal chemistry Shanshan Li, Wenda Zhang, Yanwei Yang, Ting Ma, Jianpeng Guo, Shanshan Wang, Wenying Yu, Lingyi Kong, 124, None, 2016-11-29, 2016-10-15, 10.1016/j.ejmech.2016.10.028 10.1016/j.ejmech.2016.10.028 27783972 27783972

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/stat3-in-1.html
Cambridge Bioscience https://www.bioscience.co.uk/product~1033076
ChemSrc https://www.chemsrc.com/en/cas/2059952-75-7_1558231.html

Filter data

Compound STAT3-IN-1 (compound 7d)
Experiment types Colony formation assay , Flow cytometry- annexin V binding and propidium iodide staining, Mice body weight , Western Blot
Concentrations 1.00, 10.00, 2.00, 20.00, 5.00, 8.00
Cell lines MDA-MB-231, MDA-MB-231(xenograft)
Organisms Homo sapiens, Mus musculus
Animal models
STAT proteins Ac-STAT3, STAT1, STAT3, p-STAT1(701), p-STAT3(Y705)
Other Bcl-2, Cleaved Caspase-3, Cleaved Caspase-8, Cleaved Caspase-9, Cyclin D1, GAPDH, Src, p-ERK, p-Src

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens Ac-STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens Ac-STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens Ac-STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 10.00 µM MDA-MB-231 Homo sapiens Ac-STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 10.00 µM MDA-MB-231 Homo sapiens STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 10.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity 10.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 1.00 µM MDA-MB-231 Homo sapiens p-STAT1(701)
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 2.00 µM MDA-MB-231 Homo sapiens p-STAT1(701)
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 5.00 µM MDA-MB-231 Homo sapiens p-STAT1(701)
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 1.00 µM MDA-MB-231 Homo sapiens STAT1
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 2.00 µM MDA-MB-231 Homo sapiens STAT1
STAT3-IN-1 (compound 7d) Western Blot Influence on expression of STAT target genes 5.00 µM MDA-MB-231 Homo sapiens STAT1
STAT3-IN-1 (compound 7d) Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 8.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 10.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Western Blot Influence on cell apoptosis 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Colony formation assay Influence on cell proliferation 1.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Colony formation assay Influence on cell proliferation 2.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Colony formation assay Influence on cell proliferation 5.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Colony formation assay Influence on cell proliferation 10.00 µM MDA-MB-231 Homo sapiens
STAT3-IN-1 (compound 7d) Mice body weight Influence on tumor growth 10.00 mg/kg MDA-MB-231(xenograft) Mus musculus
STAT3-IN-1 (compound 7d) Mice body weight Influence on tumor growth 20.00 mg/kg MDA-MB-231(xenograft) Mus musculus
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg MDA-MB-231(xenograft) Mus musculus p-STAT3(Y705)
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg MDA-MB-231(xenograft) Mus musculus p-STAT3(Y705)
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg MDA-MB-231(xenograft) Mus musculus STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg MDA-MB-231(xenograft) Mus musculus STAT3
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg MDA-MB-231(xenograft) Mus musculus
STAT3-IN-1 (compound 7d) Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg MDA-MB-231(xenograft) Mus musculus