Piperlongumine

Name Value
Weight 317.341 g/mol
Zinc ID ZINC899053
Smiles COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC
Molecular formula C17H19NO5
Mode of inhibition Direct STAT; Natural product
CAS 20069-09-4

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Piperlongumine and its analogs down-regulate expression of c-Met in renal cell carcinoma. Cancer biology & therapy Konstantin Golovine, Peter Makhov, Sei Naito, Henish Raiyani, Jeffrey Tomaszewski, Reza Mehrazin, Alexei Tulin, Alexander Kutikov, Robert G Uzzo, Vladimir M Kolenko, 16, 5, None, None, 10.1080/15384047.2015.1026511 10.1080/15384047.2015.1026511 25801713 PMC4623021
Piperlongumine inhibits gastric cancer cells via suppression of the JAK1,2/STAT3 signaling pathway. Molecular medicine reports Baoji Song, Hongjie Zhan, Quan Bian, Junping Gu, 13, 5, None, 2016-04-05, 10.3892/mmr.2016.5091 10.3892/mmr.2016.5091 27053336 27053336
Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene U Bharadwaj, T K Eckols, M Kolosov, M M Kasembeli, A Adam, D Torres, X Zhang, L E Dobrolecki, W Wei, M T Lewis, B Dave, J C Chang, M D Landis, C J Creighton, M A Mancini, D J Tweardy, 34, 11, 2015-03-12, 2014-03-31, 10.1038/onc.2014.72 10.1038/onc.2014.72 24681959 PMC4182178

Vendors

Company Lnk to product
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/sigma/sml0221?lang=pl&region=PL
Selleckchem https://www.selleckchem.com/products/piperlongumine.html
Caymanchemical https://www.caymanchem.com/product/11006/piperlongumine
Tocris https://www.tocris.com/products/piperlongumine_4396
ChemSpider http://www.chemspider.com/Chemical-Structure.553441.html

Filter data

Compound Piperlongumine
Experiment types Cell Titer Blue assay, Confocal and high-throughput fluorescence microscopy (HTFM), Flow cytometry , Fluorescence intensity in the nucleus (FLIN), Immunohistochemistry, Luminex assay , MTT, Migration assay , RT-qPCR, Tumor volume, Western Blot
Concentrations 0.10, 0.30, 1.00, 10.00, 100.00, 2.50, 20.00, 3.00, 30.00, 300.00, 40.00, 5.00, N/A
Cell lines 786-O, AGS, Hs 578T, Kasumi 1, MDA-MB-231, MDA-MB-468, MKN45, PNX0010, PNX0010 (xenograft), Stat3−/− MEF, patient derived xenograft 2147, patient derived xenograft 2277, patient derived xenograft 2665, patient derived xenograft 3104, patient derived xenograft 3107, patient derived xenograft 3143, patient derived xenograft 3204, patient derived xenograft 3561, patient derived xenograft 3611, patient derived xenograft 3613B, patient derived xenograft 3807, patient derived xenograft 3824, patient derived xenograft 3863, patient derived xenograft 3887, patient derived xenograft 3904, patient derived xenograft 3963, patient derived xenograft 4169, patient derived xenograft 4175, patient derived xenograft 4195, patient derived xenograft 4272, patient derived xenograft 4400, patient derived xenograft 4664, patient derived xenograft 4698, patient derived xenograft 4849, patient derived xenograft 4888, patient derived xenograft 4913, patient derived xenograft IBC3, patient derived xenograft MC1, patient derived xenograft MCF7, patient derived xenograft T47D
Organisms Homo sapiens, Mus musculus
Animal models C.B-17/Icr mice, SCID/Beige nude mice
STAT proteins STAT1, STAT3, p-STAT1, p-STAT3, p-STAT5
Other Actin, Akt, Cyclin D1, ERK1/2, GAPDH, JAK1, JAK2, Ki‑67, MMP‑9, Src, Twist, c-Met, p-Akt (Ser473), p-ERK1/2, p-JAK1, p-JAK2

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity 2.50 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 5.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM PNX0010 Homo sapiens
Piperlongumine RT-qPCR Influence on gene expression 10.00 µM 786-O Homo sapiens
Piperlongumine RT-qPCR Influence on gene expression 10.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity in presence of bortezomib 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity in presence of bortezomib 10.00 µM PNX0010 Homo sapiens
Piperlongumine Western Blot Influence on protein activity in presence of bortezomib 10.00 µM 786-O Homo sapiens
Piperlongumine Western Blot Influence on protein activity in presence of bortezomib 10.00 µM PNX0010 Homo sapiens
Piperlongumine Flow cytometry Influence on ROS generation 10.00 µM 786-O Homo sapiens
Piperlongumine Flow cytometry Influence on ROS generation 10.00 µM PNX0010 Homo sapiens
Piperlongumine Cell Titer Blue assay Influence on cell viability N/A µM 786-O Homo sapiens
Piperlongumine Cell Titer Blue assay Influence on cell viability N/A µM PNX0010 Homo sapiens
Piperlongumine Tumor volume Influence on tumor growth 20.00 mg/kg PNX0010 (xenograft) Mus musculus C.B-17/Icr mice
Piperlongumine Immunohistochemistry Influence on tumor growth 20.00 mg/kg PNX0010 (xenograft) Mus musculus C.B-17/Icr mice
Piperlongumine MTT Influence on cell viability and proliferation 10.00 µM MKN45 Homo sapiens
Piperlongumine MTT Influence on cell viability and proliferation 20.00 µM MKN45 Homo sapiens
Piperlongumine MTT Influence on cell viability and proliferation 40.00 µM MKN45 Homo sapiens
Piperlongumine MTT Influence on cell viability and proliferation 10.00 µM AGS Homo sapiens
Piperlongumine MTT Influence on cell viability and proliferation 20.00 µM AGS Homo sapiens
Piperlongumine MTT Influence on cell viability and proliferation 40.00 µM AGS Homo sapiens
Piperlongumine Flow cytometry Influence on cell cycle 10.00 µM MKN45 Homo sapiens
Piperlongumine Flow cytometry Influence on cell cycle 20.00 µM MKN45 Homo sapiens
Piperlongumine Flow cytometry Influence on cell cycle 40.00 µM MKN45 Homo sapiens
Piperlongumine Flow cytometry Influence on cell cycle 10.00 µM AGS Homo sapiens
Piperlongumine Flow cytometry Influence on cell cycle 20.00 µM AGS Homo sapiens
Piperlongumine Flow cytometry Influence on cell cycle 40.00 µM AGS Homo sapiens
Piperlongumine Migration assay Influence on cell motility 10.00 µM MKN45 Homo sapiens
Piperlongumine Migration assay Influence on cell motility 20.00 µM MKN45 Homo sapiens
Piperlongumine Migration assay Influence on cell motility 40.00 µM MKN45 Homo sapiens
Piperlongumine Migration assay Influence on cell motility 10.00 µM AGS Homo sapiens
Piperlongumine Migration assay Influence on cell motility 20.00 µM AGS Homo sapiens
Piperlongumine Migration assay Influence on cell motility 40.00 µM AGS Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens p-STAT3
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens STAT3
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 10.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 20.00 µM MKN45 Homo sapiens
Piperlongumine Western Blot Influence on protein activity 40.00 µM MKN45 Homo sapiens
Piperlongumine Confocal and high-throughput fluorescence microscopy (HTFM) Influence on protein translocation in presence of IL-6 0.10 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Confocal and high-throughput fluorescence microscopy (HTFM) Influence on protein translocation in presence of IL-6 0.30 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Confocal and high-throughput fluorescence microscopy (HTFM) Influence on protein translocation in presence of IL-6 1.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Confocal and high-throughput fluorescence microscopy (HTFM) Influence on protein translocation in presence of IL-6 3.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Confocal and high-throughput fluorescence microscopy (HTFM) Influence on protein translocation in presence of IL-6 10.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Confocal and high-throughput fluorescence microscopy (HTFM) Influence on protein translocation in presence of IL-6 30.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Confocal and high-throughput fluorescence microscopy (HTFM) Influence on protein translocation in presence of IL-6 100.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Fluorescence intensity in the nucleus (FLIN) Influence on protein translocation in presence of IL-6 0.10 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Fluorescence intensity in the nucleus (FLIN) Influence on protein translocation in presence of IL-6 0.30 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Fluorescence intensity in the nucleus (FLIN) Influence on protein translocation in presence of IL-6 1.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Fluorescence intensity in the nucleus (FLIN) Influence on protein translocation in presence of IL-6 3.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Fluorescence intensity in the nucleus (FLIN) Influence on protein translocation in presence of IL-6 10.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Fluorescence intensity in the nucleus (FLIN) Influence on protein translocation in presence of IL-6 30.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Fluorescence intensity in the nucleus (FLIN) Influence on protein translocation in presence of IL-6 100.00 µM Stat3−/− MEF Mus musculus STAT3
Piperlongumine Flow cytometry Influence on protein phosphorylation 1.00 µM Kasumi 1 Homo sapiens p-STAT3
Piperlongumine Flow cytometry Influence on protein phosphorylation 3.00 µM Kasumi 1 Homo sapiens p-STAT3
Piperlongumine Flow cytometry Influence on protein phosphorylation 10.00 µM Kasumi 1 Homo sapiens p-STAT3
Piperlongumine Flow cytometry Influence on protein phosphorylation 30.00 µM Kasumi 1 Homo sapiens p-STAT3
Piperlongumine Flow cytometry Influence on protein phosphorylation 100.00 µM Kasumi 1 Homo sapiens p-STAT3
Piperlongumine Flow cytometry Influence on protein phosphorylation 300.00 µM Kasumi 1 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.10 µM MDA-MB-468 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.30 µM MDA-MB-468 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 1.00 µM MDA-MB-468 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 3.00 µM MDA-MB-468 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 10.00 µM MDA-MB-468 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 30.00 µM MDA-MB-468 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 100.00 µM MDA-MB-468 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.10 µM MDA-MB-231 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.30 µM MDA-MB-231 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 1.00 µM MDA-MB-231 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 3.00 µM MDA-MB-231 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 10.00 µM MDA-MB-231 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 30.00 µM MDA-MB-231 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 100.00 µM MDA-MB-231 Homo sapiens p-STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.10 µM MDA-MB-468 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.30 µM MDA-MB-468 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 1.00 µM MDA-MB-468 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 3.00 µM MDA-MB-468 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 10.00 µM MDA-MB-468 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 30.00 µM MDA-MB-468 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 100.00 µM MDA-MB-468 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.10 µM MDA-MB-231 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.30 µM MDA-MB-231 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 1.00 µM MDA-MB-231 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 3.00 µM MDA-MB-231 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 10.00 µM MDA-MB-231 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 30.00 µM MDA-MB-231 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 100.00 µM MDA-MB-231 Homo sapiens STAT3
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.10 µM MDA-MB-468 Homo sapiens p-STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.30 µM MDA-MB-468 Homo sapiens p-STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 1.00 µM MDA-MB-468 Homo sapiens p-STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 3.00 µM MDA-MB-468 Homo sapiens p-STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 10.00 µM MDA-MB-468 Homo sapiens p-STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 30.00 µM MDA-MB-468 Homo sapiens p-STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 100.00 µM MDA-MB-468 Homo sapiens p-STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.10 µM MDA-MB-468 Homo sapiens STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.30 µM MDA-MB-468 Homo sapiens STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 1.00 µM MDA-MB-468 Homo sapiens STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 3.00 µM MDA-MB-468 Homo sapiens STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 10.00 µM MDA-MB-468 Homo sapiens STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 30.00 µM MDA-MB-468 Homo sapiens STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 100.00 µM MDA-MB-468 Homo sapiens STAT1
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.10 µM MDA-MB-468 Homo sapiens p-STAT5
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 0.30 µM MDA-MB-468 Homo sapiens p-STAT5
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 1.00 µM MDA-MB-468 Homo sapiens p-STAT5
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 3.00 µM MDA-MB-468 Homo sapiens p-STAT5
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 10.00 µM MDA-MB-468 Homo sapiens p-STAT5
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 30.00 µM MDA-MB-468 Homo sapiens p-STAT5
Piperlongumine Luminex assay Influence on protein activity (with and without ligand) 100.00 µM MDA-MB-468 Homo sapiens p-STAT5
Piperlongumine MTT Influence on cell growth 0.10 µM MDA-MB-231 Homo sapiens
Piperlongumine MTT Influence on cell growth 0.30 µM MDA-MB-231 Homo sapiens
Piperlongumine MTT Influence on cell growth 1.00 µM MDA-MB-231 Homo sapiens
Piperlongumine MTT Influence on cell growth 3.00 µM MDA-MB-231 Homo sapiens
Piperlongumine MTT Influence on cell growth 10.00 µM MDA-MB-231 Homo sapiens
Piperlongumine MTT Influence on cell growth 30.00 µM MDA-MB-231 Homo sapiens
Piperlongumine MTT Influence on cell growth 100.00 µM MDA-MB-231 Homo sapiens
Piperlongumine MTT Influence on cell growth 0.10 µM MDA-MB-468 Homo sapiens
Piperlongumine MTT Influence on cell growth 0.30 µM MDA-MB-468 Homo sapiens
Piperlongumine MTT Influence on cell growth 1.00 µM MDA-MB-468 Homo sapiens
Piperlongumine MTT Influence on cell growth 3.00 µM MDA-MB-468 Homo sapiens
Piperlongumine MTT Influence on cell growth 10.00 µM MDA-MB-468 Homo sapiens
Piperlongumine MTT Influence on cell growth 30.00 µM MDA-MB-468 Homo sapiens
Piperlongumine MTT Influence on cell growth 100.00 µM MDA-MB-468 Homo sapiens
Piperlongumine MTT Influence on cell growth 0.10 µM Hs 578T Homo sapiens
Piperlongumine MTT Influence on cell growth 0.30 µM Hs 578T Homo sapiens
Piperlongumine MTT Influence on cell growth 1.00 µM Hs 578T Homo sapiens
Piperlongumine MTT Influence on cell growth 3.00 µM Hs 578T Homo sapiens
Piperlongumine MTT Influence on cell growth 10.00 µM Hs 578T Homo sapiens
Piperlongumine MTT Influence on cell growth 30.00 µM Hs 578T Homo sapiens
Piperlongumine MTT Influence on cell growth 100.00 µM Hs 578T Homo sapiens
Piperlongumine Flow cytometry Influence on cell apoptosis 30.00 µM MDA-MB-468 Homo sapiens
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4400 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4849 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3613B Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3824 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4888 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4175 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3963 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft IBC3 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3807 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3204 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2277 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4664 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3887 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3107 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2665 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4169 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3561 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4698 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3143 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3104 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3611 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft MC1 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4913 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3863 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4272 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3904 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4195 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2147 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft T47D Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft MCF7 Mus musculus SCID/Beige nude mice p-STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4400 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4849 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3613B Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3824 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4888 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4175 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3963 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft IBC3 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3807 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3204 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2277 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4664 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3887 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3107 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2665 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4169 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3561 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4698 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3143 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3104 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3611 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft MC1 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4913 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3863 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4272 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3904 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4195 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2147 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft T47D Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft MCF7 Mus musculus SCID/Beige nude mice STAT3
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4400 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4849 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3613B Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3824 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4888 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4175 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3963 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft IBC3 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3807 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3204 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2277 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4664 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3887 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3107 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2665 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4169 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3561 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4698 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3143 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3104 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3611 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft MC1 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4913 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3863 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4272 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 3904 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 4195 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft 2147 Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft T47D Mus musculus SCID/Beige nude mice
Piperlongumine Luminex assay Influence on cell apoptosis 30.00 µM patient derived xenograft MCF7 Mus musculus SCID/Beige nude mice