Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5A |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP: EGFR IB: STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP: EGFR IB: STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP: EGFR IB: STAT5 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP: EGFR IB: STAT5 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
U266 |
Homo sapiens |
|
IP: GP130 IB: STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
U266 |
Homo sapiens |
|
IP: GP130 IB: STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
RPMI-8226 |
Homo sapiens |
|
IP: GP130 IB: STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
RPMI-8226 |
Homo sapiens |
|
IP: GP130 IB: STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
RPMI-8226 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
RPMI-8226 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
RPMI-8226 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
RPMI-8226 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.10 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.30 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
1.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
3.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
10.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.10 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.30 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
1.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
3.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
10.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.10 µM |
U266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.30 µM |
U266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
1.00 µM |
U266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
3.00 µM |
U266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
10.00 µM |
U266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.10 µM |
U266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.30 µM |
U266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
1.00 µM |
U266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
3.00 µM |
U266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
10.00 µM |
U266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.10 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
0.30 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
1.00 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
3.00 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IL-6 |
10.00 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.10 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.30 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
1.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
3.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
10.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.10 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.30 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
1.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
3.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
10.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.10 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.30 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
1.00 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
3.00 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
10.00 µM |
U266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH 3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH 3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH 3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH 3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH 3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH 3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH 3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH 3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH 3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH 3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH 3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH 3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH 3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH 3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH 3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH 3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Immunofluorescence |
Influence on protein-DNA interaction in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Immunofluorescence |
Influence on protein-DNA interaction in presence of EGF |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Immunofluorescence |
Influence on protein-DNA interaction in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Immunofluorescence |
Influence on protein-DNA interaction in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Immunofluorescence |
Influence on protein-DNA interaction in presence of EGF |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Immunofluorescence |
Influence on protein-DNA interaction in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferase activity |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 pLucSRE |
Homo sapiens |
|
|
|
Withacnistin |
Luciferase activity |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 pLucSRE |
Homo sapiens |
|
|
|
Withacnistin |
Luciferase activity |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 pLucSRE |
Homo sapiens |
|
|
|
Withacnistin |
Luciferase activity |
Influence on expression of proteins downstream target genes |
3.00 µM |
MDA-MB-468 pLucTKS3 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferase activity |
Influence on expression of proteins downstream target genes |
5.00 µM |
MDA-MB-468 pLucTKS3 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferase activity |
Influence on expression of proteins downstream target genes |
10.00 µM |
MDA-MB-468 pLucTKS3 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Invasion assay |
Influence on cell motility |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Invasion assay |
Influence on cell motility |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Invasion assay |
Influence on cell motility |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Invasion assay |
Influence on cell motility |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
1.00 µM |
A549 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
3.00 µM |
A549 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
5.00 µM |
A549 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
10.00 µM |
A549 |
Homo sapiens |
|
|
|
Withacnistin |
Tumor volume |
Influence on tumor growth |
20.00 mg/kg/day |
breast tumor tissue |
Mus musculus |
ErbB2 |
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP:EGFR IB:STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP:EGFR IB:STAT5 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP:EGFR IB:STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
IP:EGFR IB:STAT5 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
IP:GP130 IB:STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
5.00 µM |
U-266 |
Homo sapiens |
|
IP:GP130 IB:STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
5.00 µM |
U-266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
5.00 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
5.00 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
10.00 µM |
RPMI-8226 |
Homo sapiens |
|
IP:GP130 IB:STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
10.00 µM |
RPMI-8226 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
10.00 µM |
RPMI-8226 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
10.00 µM |
RPMI-8226 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
5.00 µM |
RPMI-8226 |
Homo sapiens |
|
IP:GP130 IB:STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
5.00 µM |
RPMI-8226 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
5.00 µM |
RPMI-8226 |
Homo sapiens |
|
|
|
Withacnistin |
Co-immunoprecipitation |
Influence on protein activity in presence of EGF |
5.00 µM |
RPMI-8226 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
U-266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
U-266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
U-266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
U-266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
U-266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
U-266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
U-266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
U-266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
U-266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
U-266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
U-266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
U-266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.10 µM |
U-266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
0.30 µM |
U-266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
1.00 µM |
U-266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
3.00 µM |
U-266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of EGF |
10.00 µM |
U-266 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.10 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
0.30 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
1.00 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
3.00 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of GMCSF |
10.00 µM |
TF-1 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.10 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.30 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
1.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
3.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
10.00 µM |
TF-1 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.10 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.30 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
1.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
3.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
10.00 µM |
TF-1 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.10 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
0.30 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
1.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
3.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of IFNβ |
10.00 µM |
TF-1 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH3T3 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH3T3 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH3T3 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.10 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
0.30 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
1.00 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
3.00 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity in presence of PDGF-BB |
10.00 µM |
NIH3T3 |
Homo sapiens |
|
|
|
Withacnistin |
Immunofluorescence |
Infleunce on protein translocation in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Immunofluorescence |
Infleunce on protein translocation in presence of EGF |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Immunofluorescence |
Infleunce on protein translocation in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Immunofluorescence |
Infleunce on protein translocation in presence of EGF |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Immunofluorescence |
Infleunce on protein translocation in presence of EGF |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Immunofluorescence |
Infleunce on protein translocation in presence of EGF |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Luciferse activity |
Influence on protein transcriptiona activity |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferse activity |
Influence on protein transcriptiona activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferse activity |
Influence on protein transcriptiona activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferse activity |
Influence on protein transcriptiona activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferse activity |
Influence on protein transcriptiona activity |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferse activity |
Influence on protein transcriptiona activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferse activity |
Influence on protein transcriptiona activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Luciferse activity |
Influence on protein transcriptiona activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT3 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
p-STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
STAT5 |
|
Withacnistin |
Western Blot |
Influence on protein activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Western Blot |
Influence on protein activity |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
5.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
1.00 µM |
A549 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
3.00 µM |
A549 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
5.00 µM |
A549 |
Homo sapiens |
|
|
|
Withacnistin |
Colony formation assay |
Influence on cell motility |
10.00 µM |
A549 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
0.10 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
0.30 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
1.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
3.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
TUNEL |
Influence on cell apoptosis |
10.00 µM |
MDA-MB-468 |
Homo sapiens |
|
|
|
Withacnistin |
Tumor volume |
Influence on tumor growth |
20.00 mg/kg |
MDA-MB-468(xenograft) |
Mus musculus |
ErbB2 |
|
|