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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
Withacnistin Influence on protein activity in presence of EGF Western Blot 10.00 µM MDA-MB-468 Homo sapiens p-STAT3
Withacnistin Influence on protein activity in presence of EGF Western Blot 10.00 µM MDA-MB-468 Homo sapiens STAT3
Withacnistin Influence on protein activity in presence of EGF Western Blot 10.00 µM MDA-MB-468 Homo sapiens p-STAT5A
Withacnistin Influence on protein activity in presence of EGF Western Blot 10.00 µM MDA-MB-468 Homo sapiens STAT5
Withacnistin Influence on protein activity in presence of EGF Western Blot 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM MDA-MB-468 Homo sapiens IP: EGFR IB: STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM MDA-MB-468 Homo sapiens IP: EGFR IB: STAT5
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM MDA-MB-468 Homo sapiens STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM U266 Homo sapiens IP: GP130 IB: STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM U266 Homo sapiens STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM U266 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM RPMI-8226 Homo sapiens IP: GP130 IB: STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM RPMI-8226 Homo sapiens STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 10.00 µM RPMI-8226 Homo sapiens
Withacnistin Influence on protein activity in presence of EGF Western Blot 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity in presence of EGF Western Blot 10.00 µM MDA-MB-468 Homo sapiens p-STAT5
Withacnistin Influence on protein activity in presence of IL-6 Western Blot 10.00 µM U266 Homo sapiens p-STAT3
Withacnistin Influence on protein activity in presence of IL-6 Western Blot 10.00 µM U266 Homo sapiens STAT3
Withacnistin Influence on protein activity in presence of IL-6 Western Blot 10.00 µM U266 Homo sapiens p-STAT5
Withacnistin Influence on protein activity in presence of IL-6 Western Blot 10.00 µM U266 Homo sapiens STAT5
Withacnistin Influence on protein activity in presence of IL-6 Western Blot 10.00 µM U266 Homo sapiens
Withacnistin Influence on protein activity in presence of GMCSF Western Blot 10.00 µM TF-1 Homo sapiens p-STAT3
Withacnistin Influence on protein activity in presence of GMCSF Western Blot 10.00 µM TF-1 Homo sapiens STAT3
Withacnistin Influence on protein activity in presence of GMCSF Western Blot 10.00 µM TF-1 Homo sapiens p-STAT5
Withacnistin Influence on protein activity in presence of GMCSF Western Blot 10.00 µM TF-1 Homo sapiens STAT5
Withacnistin Influence on protein activity in presence of GMCSF Western Blot 10.00 µM TF-1 Homo sapiens
Withacnistin Influence on protein activity in presence of IFNβ Western Blot 10.00 µM U266 Homo sapiens p-STAT3
Withacnistin Influence on protein activity in presence of IFNβ Western Blot 10.00 µM U266 Homo sapiens STAT3
Withacnistin Influence on protein activity in presence of IFNβ Western Blot 10.00 µM U266 Homo sapiens
Withacnistin Influence on protein activity in presence of PDGF-BB Western Blot 10.00 µM NIH 3T3 Homo sapiens p-STAT3
Withacnistin Influence on protein activity in presence of PDGF-BB Western Blot 10.00 µM NIH 3T3 Homo sapiens STAT3
Withacnistin Influence on protein activity in presence of PDGF-BB Western Blot 10.00 µM NIH 3T3 Homo sapiens p-STAT5
Withacnistin Influence on protein activity in presence of PDGF-BB Western Blot 10.00 µM NIH 3T3 Homo sapiens STAT5
Withacnistin Influence on protein activity in presence of PDGF-BB Western Blot 10.00 µM NIH 3T3 Homo sapiens
Withacnistin Influence on protein-DNA interaction in presence of EGF Immunofluorescence 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein-DNA interaction in presence of EGF Immunofluorescence 10.00 µM MDA-MB-468 Homo sapiens p-STAT3
Withacnistin Influence on expression of proteins downstream target genes Western Blot 10.00 µM MDA-MB-468 Homo sapiens p-STAT3
Withacnistin Influence on expression of proteins downstream target genes Western Blot 10.00 µM MDA-MB-468 Homo sapiens STAT3
Withacnistin Influence on expression of proteins downstream target genes Western Blot 10.00 µM MDA-MB-468 Homo sapiens p-STAT5
Withacnistin Influence on expression of proteins downstream target genes Western Blot 10.00 µM MDA-MB-468 Homo sapiens STAT5
Withacnistin Influence on expression of proteins downstream target genes Western Blot 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on expression of proteins downstream target genes Western Blot 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on expression of proteins downstream target genes Western Blot 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on expression of proteins downstream target genes Luciferase activity 10.00 µM MDA-MB-468 pLucSRE Homo sapiens
Withacnistin Influence on expression of proteins downstream target genes Luciferase activity 10.00 µM MDA-MB-468 pLucTKS3 Homo sapiens
Withacnistin Influence on cell apoptosis TUNEL 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on cell motility Invasion assay 10.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on cell motility Colony formation assay 10.00 µM MDA-MB-468 Homo sapiens