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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens IP: EGFR IB: STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens IP: EGFR IB: STAT5
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM U266 Homo sapiens IP: GP130 IB: STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM U266 Homo sapiens STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM U266 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM RPMI-8226 Homo sapiens IP: GP130 IB: STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM RPMI-8226 Homo sapiens STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM RPMI-8226 Homo sapiens
Withacnistin Influence on protein-DNA interaction in presence of EGF Immunofluorescence 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein-DNA interaction in presence of EGF Immunofluorescence 5.00 µM MDA-MB-468 Homo sapiens p-STAT3
Withacnistin Influence on expression of proteins downstream target genes Western Blot 5.00 µM MDA-MB-468 Homo sapiens p-STAT3
Withacnistin Influence on expression of proteins downstream target genes Western Blot 5.00 µM MDA-MB-468 Homo sapiens STAT3
Withacnistin Influence on expression of proteins downstream target genes Western Blot 5.00 µM MDA-MB-468 Homo sapiens p-STAT5
Withacnistin Influence on expression of proteins downstream target genes Western Blot 5.00 µM MDA-MB-468 Homo sapiens STAT5
Withacnistin Influence on expression of proteins downstream target genes Western Blot 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on expression of proteins downstream target genes Western Blot 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on expression of proteins downstream target genes Western Blot 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on expression of proteins downstream target genes Luciferase activity 5.00 µM MDA-MB-468 pLucSRE Homo sapiens
Withacnistin Influence on expression of proteins downstream target genes Luciferase activity 5.00 µM MDA-MB-468 pLucTKS3 Homo sapiens
Withacnistin Influence on cell motility Invasion assay 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on cell motility Colony formation assay 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on cell motility Colony formation assay 5.00 µM A549 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens IP:EGFR IB:STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens IP:EGFR IB:STAT5
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens STAT3
Withacnistin Influence on protein activity Co-immunoprecipitation 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity in presence of EGF Co-immunoprecipitation 5.00 µM U-266 Homo sapiens IP:GP130 IB:STAT3
Withacnistin Influence on protein activity in presence of EGF Co-immunoprecipitation 5.00 µM U-266 Homo sapiens STAT3
Withacnistin Influence on protein activity in presence of EGF Co-immunoprecipitation 5.00 µM U-266 Homo sapiens
Withacnistin Influence on protein activity in presence of EGF Co-immunoprecipitation 5.00 µM U-266 Homo sapiens
Withacnistin Influence on protein activity in presence of EGF Co-immunoprecipitation 5.00 µM RPMI-8226 Homo sapiens IP:GP130 IB:STAT3
Withacnistin Influence on protein activity in presence of EGF Co-immunoprecipitation 5.00 µM RPMI-8226 Homo sapiens STAT3
Withacnistin Influence on protein activity in presence of EGF Co-immunoprecipitation 5.00 µM RPMI-8226 Homo sapiens
Withacnistin Influence on protein activity in presence of EGF Co-immunoprecipitation 5.00 µM RPMI-8226 Homo sapiens
Withacnistin Infleunce on protein translocation in presence of EGF Immunofluorescence 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Infleunce on protein translocation in presence of EGF Immunofluorescence 5.00 µM MDA-MB-468 Homo sapiens p-STAT3
Withacnistin Influence on protein transcriptiona activity Luciferse activity 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein transcriptiona activity Luciferse activity 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Western Blot 5.00 µM MDA-MB-468 Homo sapiens p-STAT3
Withacnistin Influence on protein activity Western Blot 5.00 µM MDA-MB-468 Homo sapiens STAT3
Withacnistin Influence on protein activity Western Blot 5.00 µM MDA-MB-468 Homo sapiens p-STAT5
Withacnistin Influence on protein activity Western Blot 5.00 µM MDA-MB-468 Homo sapiens STAT5
Withacnistin Influence on protein activity Western Blot 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Western Blot 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on protein activity Western Blot 5.00 µM MDA-MB-468 Homo sapiens
Withacnistin Influence on cell motility Colony formation assay 5.00 µM MDA-MB-468 Homo sapiens