| PG-S3-001 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
10.00 mg/kg |
Pa03C (patient derived) |
Mus musculus |
NSG |
|
|
| Simvastatin |
Influence on cell proliferation |
Bromodeoxyuridine (BrdU) incorporation assay |
0.10 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
Bromodeoxyuridine (BrdU) incorporation assay |
1.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
Bromodeoxyuridine (BrdU) incorporation assay |
10.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
0.10 µM |
BRL-4 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
0.30 µM |
BRL-4 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
1.00 µM |
BRL-4 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
3.00 µM |
BRL-4 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
10.00 µM |
BRL-4 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
30.00 µM |
BRL-4 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
0.10 µM |
MCF-7 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
0.30 µM |
MCF-7 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
1.00 µM |
MCF-7 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
3.00 µM |
MCF-7 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
10.00 µM |
MCF-7 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell proliferation |
MTT Assay |
30.00 µM |
MCF-7 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Wound healing assay |
1.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Wound healing assay |
3.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Wound healing assay |
10.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Migration assay |
0.50 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Migration assay |
1.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Migration assay |
3.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Migration assay |
5.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Migration assay |
10.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Invasion assay |
0.50 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Invasion assay |
1.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Invasion assay |
3.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Invasion assay |
5.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on cell motility |
Invasion assay |
10.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
1.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
3.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
5.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
1.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
3.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
5.00 µM |
UMR-106 |
Homo sapiens |
|
|
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
1.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT5(Y694) |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
3.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT5(Y694) |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
5.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT5(Y694) |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
1.00 µM |
UMR-106 |
Homo sapiens |
|
STAT5 |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
3.00 µM |
UMR-106 |
Homo sapiens |
|
STAT5 |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
5.00 µM |
UMR-106 |
Homo sapiens |
|
STAT5 |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
1.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT3(Y705) |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
3.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT3(Y705) |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
5.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT3(Y705) |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
1.00 µM |
UMR-106 |
Homo sapiens |
|
STAT3 |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
3.00 µM |
UMR-106 |
Homo sapiens |
|
STAT3 |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
5.00 µM |
UMR-106 |
Homo sapiens |
|
STAT3 |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
1.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT1(Y701) |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
3.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT1(Y701) |
|
| Simvastatin |
Influence on protein activity (2h) in presence of GH |
Western Blot |
5.00 µM |
UMR-106 |
Homo sapiens |
|
p-STAT1(Y701) |
|
