PG-S3-001

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics. Molecular cancer therapeutics Carolyn C Arpin, Stephen Mac, Yanlin Jiang, Huiwen Cheng, Michelle Grimard, Brent D G Page, Malgorzata M Kamocka, Sina Haftchenary, Han Su, Daniel P Ball, David A Rosa, Ping-Shan Lai, Rodolfo F Gómez-Biagi, Ahmed M Ali, Rahul Rana, Helmut Hanenberg, Kagan Kerman, Kyle C McElyea, George E Sandusky, Patrick T Gunning, Melissa L Fishel, 15, 5, None, 2016-02-12, 10.1158/1535-7163.MCT-15-0003 10.1158/1535-7163.MCT-15-0003 26873728 PMC4873422

Vendors

Company Lnk to product
ProbeChem http://www.probechem.com/products_PG-S3-001.aspx

Filter data

Compound PG-S3-001
Experiment types Alamar Blue assay, Average weight, Fluorescence polarization competition assay , MTS Assay , Proliferation assay , Surface Plasmon Resonance, Tumor volume, Western Blot
Concentrations 0.01, 0.10, 10.00, 100.00, 1000.00, 12.50, 25.00, 4.00, 5.00, 6.25, N/A
Cell lines CAF19, CCD-13Lu, Pa02C, Pa03C, Pa03C (patient derived), PaCa-2
Organisms Homo sapiens, Mus musculus
Animal models NSG
STAT proteins STAT3, p-STAT3
Other Survivin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
PG-S3-001 Fluorescence polarization competition assay Inhibitor interaction with protein 0.01 µM STAT3
PG-S3-001 Fluorescence polarization competition assay Inhibitor interaction with protein 0.10 µM STAT3
PG-S3-001 Fluorescence polarization competition assay Inhibitor interaction with protein 10.00 µM STAT3
PG-S3-001 Fluorescence polarization competition assay Inhibitor interaction with protein 100.00 µM STAT3
PG-S3-001 Fluorescence polarization competition assay Inhibitor interaction with protein 1000.00 µM STAT3
PG-S3-001 Surface Plasmon Resonance Inhibitor interaction with protein 0.01 µM STAT3
PG-S3-001 Surface Plasmon Resonance Inhibitor interaction with protein 0.10 µM STAT3
PG-S3-001 Surface Plasmon Resonance Inhibitor interaction with protein 10.00 µM STAT3
PG-S3-001 Surface Plasmon Resonance Inhibitor interaction with protein 100.00 µM STAT3
PG-S3-001 Surface Plasmon Resonance Inhibitor interaction with protein 1000.00 µM STAT3
PG-S3-001 Alamar Blue assay Influence on cell proliferation N/A N/A Pa03C Homo sapiens
PG-S3-001 Alamar Blue assay Influence on cell proliferation N/A N/A CAF19 Homo sapiens
PG-S3-001 MTS Assay Influence on cytotoxicity 6.25 µM Pa03C Homo sapiens
PG-S3-001 MTS Assay Influence on cytotoxicity 6.25 µM CAF19 Homo sapiens
PG-S3-001 MTS Assay Influence on cytotoxicity 6.25 µM CCD-13Lu Homo sapiens
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 5.00 µM PaCa-2 Homo sapiens p-STAT3
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 10.00 µM PaCa-2 Homo sapiens p-STAT3
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 5.00 µM PaCa-2 Homo sapiens STAT3
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 10.00 µM PaCa-2 Homo sapiens STAT3
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 5.00 µM Pa02C Homo sapiens p-STAT3
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 10.00 µM Pa02C Homo sapiens p-STAT3
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 5.00 µM Pa02C Homo sapiens STAT3
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 10.00 µM Pa02C Homo sapiens STAT3
PG-S3-001 Western Blot Influence on protein activity in presence of IL-6 4.00 µM CAF19 Homo sapiens
PG-S3-001 Proliferation assay Influence on cell proliferation 12.50 µM Pa03C (patient derived) Homo sapiens
PG-S3-001 Proliferation assay Influence on cell proliferation 25.00 µM Pa03C (patient derived) Homo sapiens
PG-S3-001 Average weight Influence on cell proliferation in tumor tissue 10.00 mg/kg Pa03C (patient derived) Mus musculus NSG
PG-S3-001 Tumor volume Influence on cell proliferation in tumor tissue 10.00 mg/kg Pa03C (patient derived) Mus musculus NSG