Simvastatin

Name Value
Weight 418.574 g/mol
Zinc ID ZINC3780893
Smiles CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21
Molecular formula C25H38O5
Mode of inhibition JAK and STAT inhibitor; Non-peptide small molecule
CAS 79902-63-9

Clinical Trials

Study title Status Conditions Link
Simvastatin Metabolism as a Test for CD Activity (IRB 15-007568] Completed Celiac Disease NCT03011931
Role of Simvastatin in Relapsing-Remitting Multiple Sclerosis Not yet recruiting Simvastatin Multiple Sclerosis NCT04178980
Simvastatin Plus Dual Anti-HER2 Therapy for Metastatic Breast Cancer Recruiting Breast Cancer Stage IV NCT03324425
Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell Disease Completed Sickle Cell Disease NCT01702246
Simvastatin in Uveitis Completed Uveitis NCT04183387
Safety of Simvastatin in LAM and TSC Active, not recruiting Lymphangioleiomyomatosis|Tuberous Sclerosis Complex NCT02061397
Efficacy Study of SIMVASTATIN to Treat Chronic Rhinosinusitis After Failure of Optimal Treatment Terminated Rhinosinusitis NCT01771198
Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent Simvastatin Active, not recruiting Breast Cancer|Stage I Breast Cancer|Stage II Breast Cancer|Stage III Breast Cancer NCT02096588
Simvastatin in Secondary Progressive Multiple Sclerosis Recruiting Secondary Progressive Multiple Sclerosis NCT03896217
Drug-drug Interaction Between Simvastatin and SHR3824 Unknown status Type 2 Diabetes NCT03329118
Study to Assess the Effect of AZD9291 on the Blood Levels of Simvastatin in Patients With EGFRm+ NSCLC Active, not recruiting Non Small Cell Lung Cancer NCT02197234
Treatment of Graves´Ophthalmopathy With Simvastatin (GO-DS) Recruiting Graves Ophthalmopathy|Thyroid Associated Ophthalmopathy|Thyroid Associated Orbitopathy NCT03131726
Donor Simvastatin Treatment in Organ Transplantation Completed Heart Failure|Respiratory Failure|Liver Failure|Kidney Failure|Transplantation NCT01160978
The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids on p38 MAPK in Asthma Completed Asthma NCT01266434
Trial of Simvastatin for the Treatment of Severe Asthma Withdrawn Severe Asthma NCT02433535
Capecitabine Plus Simvastatin in Locally Advanced Rectal Cancer Patients Active, not recruiting Adenocarcinoma of Rectum NCT02161822
The Evaluation of Vitiligous Lesions Repigmentation After the Administration of Atorvastatin Calcium Salt and Simvastatin-acid Sodium Salt in Patients With Active Vitiligo Unknown status Non-segmental Vitiligo NCT03247400
Study of Metformin With Simvastatin for Men With Prostate Carcinoma Withdrawn Prostate Carcinoma NCT01561482
Simvastatin Therapy in Patients With Dilated Cardiomyopathy. Recruiting Dilated Cardiomyopathy NCT03775070
Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG) Not yet recruiting Obesity|Hyperlipidemias NCT03571802
Simvastatin to Prevent SCI-Induced Bone Loss Recruiting Spinal Cord Injuries|Osteoporosis NCT02946424
Stroke Treatment With Acute Reperfusion and Simvastatin Completed Stroke, Acute NCT01073007
The Drug-drug Interaction of SP2086 and Simvastatin Completed Type 2 Diabetes NCT02815722
Simvastatin add-on Treatment to Standard Antidepressant Therapy in Patients With Comorbid Obesity and Major Depression Recruiting Depressive Disorder, Major|Obesity NCT04301271
Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Risk Compensated Cirrhosis Not yet recruiting Cirrhosis NCT03654053
Efficacy of High and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcome in Patients With AIS Completed Ischemic Stroke NCT03402204
Simvastatin in the Prevention of Recurrent Pancreatitis Recruiting Pancreatitis Relapsing NCT04021498
The Short-term Effects of Simvastatin on the Vision of Males Affected by Choroideremia Terminated Choroideremia NCT01654562
A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics, Pharmacodynamics, and Safety of Simvastatin in Healthy Volunteers Completed Healthy NCT01821027
A Drug Interaction Study of Simvastatin and Albiglutide Completed Diabetes Mellitus, Type 2 NCT01147692
Simvastatin for mTBI Completed TBI-Traumatic Brain Injury NCT01952288
Curcumin-Simvastatin-EDTA in the Treatment of Periodontitis Completed Periodontitis NCT04044417
Use of Topical Subgingival Application of Simvastatin Gel in the Treatment of Peri-Implant Mucositis Completed Peri-implant Mucositis NCT03400475
Evaluate the Effects of the Environmental Change in Intestine by Antibiotics on the Pharmacokinetic Characteristics of Simvastatin in Healthy Male Volunteers Completed Simvastatin Pharmacokinetics and Gut Microbiome NCT03403972
A Phase I Study of High Dose Simvastatin in Patients With Gastrointestinal Tract Cancer Who Failed to Standard Chemotherapy Recruiting Stomach Cancer NCT03086291
The DDI Study of SP2086 and Simvastatin Unknown status Type 2 Diabetes NCT02817243
A Study of Baricitinib and Simvastatin in Healthy Participants Completed Healthy Volunteers NCT01960140
Effects of Simvastatin on Uterine Leiomyoma Size Recruiting Fibroid Uterus|Fibroid Tumor|Leiomyoma|Fibromyoma|Leiomyoma, Uterine NCT03400826
Evaluate the Pharmacokinetics of Simvastatin When Coadministered With PEX168 in Healthy Adult Subjects Completed Type 2 Diabetes Mellitus NCT02447601
Study for Identifying Optimal Simvastatin Formulation for Uniform Time to Maximum Plasma Concentration Terminated Celiac Disease NCT01642862
Efficacy and Safety of Simvastatin-ezetimibe Combination Therapy Among Patients With SLE Unknown status Atherosclerosis NCT02548936
Bioequivalence Study of Simvastatin Tablets, 80 mg of Dr. Reddy's Under Fed Conditions Completed Healthy NCT01167933
Bioequivalence Study of Simvastatin Tablets 80 mg of Dr. Reddy's Under Fasting Condition Completed Healthy NCT01167894
The Effect of Simvastatin Combined With Ezetimibe in Patients With Stable Angina and Diabetes Recruiting Coronary Heart Disease NCT03771053
Simvastatin Addition for Patients With Recent-onset Schizophrenia Unknown status Schizophrenia|Schizoaffective Disorder|Schizophreniform Disorder|Psychosis NOS NCT01999309
Multiple Sclerosis-Simvastatin Trial 2 Recruiting Secondary Progressive Multiple Sclerosis (SPMS) NCT03387670
Simvastatin for the Treatment of Chronic Hepatitis B Completed Hepatitis B NCT00994773
Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis Completed Chronic Periodontitis NCT03419429
Lipid Biomarker Study in Men With Dyslipidemia After Simvastatin Treatment (Study MK-0000-140)(COMPLETED) Completed Hypercholesterolemia, Dyslipidemia NCT00935259
Randomized Comparative Efficacy and Safety Study of Intermittent Simvastatin and Fenofibrate in Hemodialysis Completed Fenofibrate/Simvastatin Comparison NCT02886299
Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker Assessment Completed Metabolic Syndrome NCT00819403
The Effect of Simvastatin Therapy on the Expression of Procoagulant and Inflammatory Markers in Heart Failure Completed Heart Failure NCT00769210
Cilostazol-Simvastatin Drug Interaction Study Unknown status Dyslipidemias|Peripheral Artery Disease NCT02431013
Simvastatin (Zocor) Therapy in Sickle Cell Disease Completed Sickle Cell Disease NCT00508027
Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage Terminated Aneurysmal Subarachnoid Hemorrhage|Cerebral Vasospasm NCT00487461
Simvastatin and Metformin in Chronic Periodontitis Completed Chronic Periodontitis NCT02372656
The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin Study Completed Metabolic Syndrome NCT00817843
Evaluation of Efficacy and Safety of Combined Omacor (Omega-3-acid Ethyl Esters) and Simvastatin Therapy in Hypertriglyceridemic Subjects Completed Hypertriglyceridemia NCT00246701
Use of Simvastatin as a Steroid Sparing Agent for Uveitis Patients Unknown status Uveitis NCT02252328
Effect of Repeated Administration of Eslicarbazepine Acetate on the Pharmacokinetics of Simvastatin in Healthy Subjects Completed Epilepsy NCT00987558
Trial of XELIRI/FOLFIRI + Simvastatin Followed by Simvastatin Maintenance in Metastatic Colorectal Cancer Unknown status Colorectal Cancer NCT01238094
Clinical Trial of Zocor (Simvastatin) and Vytorin (Ezetimibe/Simvastatin) in Adolescents With Type 1 Diabetes Completed Type 1 Diabetes Mellitus|Dyslipidemia NCT00477204
Metformin and Simvastatin Use in Bladder Cancer Unknown status Bladder Cancer NCT02360618
Metformin and Simvastatin in Addition to Fulvestrant Unknown status Breast Cancer NCT03192293
Simvastatin Augmentation of Lithium Treatment in Bipolar Depression Terminated Bipolar Disorder NCT01665950
Clinical and Economic Outcome of Simvastatin in Critically Ill Septic Patient Completed Critical Illness NCT02067949
Effects of Simvastatin on Biomarkers Completed Alzheimer's Disease NCT01142336
Trial of Simvastatin and Gemcitabine in Pancreatic Cancer Patients Completed Pancreatic Cancer NCT00944463
A Study to Assess Co-Administered AZD9056 (Steady State) and Simvastatin (Single Dose) in Healthy Volunteers Completed Healthy Volunteers NCT00736606
High-dose HMG-CoA Inhibitor Simvastatin Relapsed CLL Completed Chronic Lymphocytic Leukemia NCT00828282
Effect of Cilostazol on the Pharmacokinetics of Simvastatin Completed Healthy NCT01383395
Simvastatin in Preventing a New Breast Cancer in Women at High Risk for a New Breast Cancer Completed Breast Cancer NCT00334542
SLOS: The Effect of Simvastatin in Patients Receiving Cholesterol Supplementation Terminated Smith-Lemli-Opitz Syndrome NCT01434745
Simvastatin Effect on Radiation Therapy of Brain Metastases Completed Brain Metastases NCT02104193
Overcoming Chemotherapy Resistance In Refractory Multiple Myeloma With Simvastatin and Zoledronic Acid Terminated Multiple Myeloma NCT01772719
Simvastatin Therapy for Moderate and Severe COPD Terminated Pulmonary Disease, Chronic Obstructive NCT01061671
Simvastatin in Overcoming Chemotherapy Resistance in Patients With Relapsed or Refractory Multiple Myeloma Withdrawn Recurrent Plasma Cell Myeloma|Refractory Plasma Cell Myeloma NCT02971410
Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial. Recruiting Treatment Resistant Depression|Major Depressive Disorder NCT03435744
Simvastatin in Waldenstrom's Macroglobulinemia Terminated Waldenstrom's Macroglobulinemia NCT00575965
Effect of SSP-004184 (SPD602) on the Pharmacokinetics of Simvastatin in Healthy Adult Subjects Completed Healthy NCT01979185
Add-on Simvastatin in Schizophrenia Trial Terminated Schizophrenia NCT00605995
Safety and Efficacy Study Comparing ABT-143 to Simvastatin in Subjects With Elevated Levels of Low Density Lipoprotein Cholesterol ("Bad Cholesterol") and Triglycerides Completed Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia NCT00812955
Simvastatin in Chronic Obstructive Pulmonary Disease (COPD) Unknown status COPD|Emphysema NCT00680641
The Effect of Simvastatin on Desensitization of Panel-Positive Kidney Transplant Candidates Completed Renal Transplantation NCT00693576
Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With Simvastatin Active, not recruiting Sickle Cell Disease|Stroke NCT03599609
The Effect of Multiple Doses of Epanova® on the Multiple-Dose Pharmacokinetics of Simvastatin in Healthy Normal Subjects Completed Hypertriglyceridemia NCT01486433
A Study to Investigate the Interaction of GSK1292263 With Rosuvastatin and Simvastatin in Healthy Subjects Completed Diabetes Mellitus, Type 2 NCT01101568
Effect of Ezetimibe or Simvastatin or Both on Low Densitiy Lipoprotein -Subfractions in Patients With Type 2 Diabetes Completed Diabetes Mellitus Type 2|Hypercholesterolemia NCT01384058
Trial of XP (Capecitabine/CDDP) Simvastatin in Advanced Gastric Cancer Patients Completed Gastric Cancer NCT01099085
Effect of Simvastatin on the Prognosis of Primary Primary Sclerosing Cholangitis (PSC) Not yet recruiting Primary Sclerosing Cholangitis NCT04133792
Simvastatin and Diastolic Dysfunction Completed Diastolic Dysfunction|Hypertension NCT01061450
Sarilumab Effect on the Pharmacokinetics of Simvastatin Completed Rheumatoid Arthritis NCT02017639
Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol Enrolling by invitation Obesity|Bariatric Surgery Candidate NCT04049786
Drug Interaction Study of Simvastatin and Dabigatran Completed Healthy NCT03728101
Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL) Completed Hypercholesterolemia NCT00932620
Efficacy of Ezetimibe/Simvastatin 10/20 mg and MK0524A (1-2 g/Day) in Mixed Hyperlipidemia and Two or More Risk Factors Withdrawn Cardiovascular Diseases|Hyperlipidemia NCT00738985
Interaction Study SLV337/Simvastatin Completed Type 2 Diabetes Mellitus NCT00924430
The Effect of XueZhiKang on Fatigue：Comparing With Simvastatin Completed Dyslipidemias NCT01686451
Open-Label Extension of a Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Lovaza® and Simvastatin Therapy in Hypertriglyceridemic Subjects Completed Hypertriglyceridemia NCT00903409
Effect of Gemcabene on the Pharmacokinetics of Simvastatin in Healthy Volunteers Completed Hypercholesterolemia NCT02587390
Simvastatin as a Treatment for Pulmonary Hypertension Completed Pulmonary Hypertension NCT00180713
Pharmacokinetics of Simvastatin and Its Metabolite Simvastatin Acid With and Without Concomitant Administration of Telmisartan in Healthy Subjects Completed Healthy NCT02187536
Effects of Simvastatin and Micronized Trans-resveratrol Treatment on Polycystic Ovary Syndrome (PCOS) Patients Unknown status PCOS, Insulin Resistance NCT02766803
Simvastatin Effect on Portal Hypertension Completed Portal Hypertension|Esophageal Varices|Liver Cirrhosis NCT02134626
Evaluate the Efficacy and Safety of Rosuvastatin Versus Simvastatin in Type 2 Diabetic Patients With Dyslipidemia Completed Diabetes Mellitus|Dyslipidemia NCT00506961
Ezetimibe Plus Simvastatin Versus Simvastatin in Untreated Subjects With High Cholesterol (P03435) Completed Hypercholesterolaemia|Atherosclerosis NCT00653835
Evaluation Of The Portal Pressure By Doppler Ultrasound In Cirrhotic Patients Before And After Simvastatin Completed Portal Hypertension NCT02994485
Efficacy of the Combination of Simvastatin Plus Rifaximin in Patients With Decompensated Cirrhosis to Prevent ACLF Development Recruiting Liver Cirrhoses NCT03780673
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) Completed Metastatic Colorectal Cancer NCT01281761
Clinical Trial of Simvastatin to Treat Generalized Vitiligo Completed Vitiligo NCT01517893
Simvastatin as a Neuroprotective Treatment for Moderate Parkinson's Disease Active, not recruiting Parkinson Disease NCT02787590
Drug Interaction Study of MGL-3196 With Rosuvastatin and Simvastatin Completed Healthy NCT02542969
Assess the Pharmacokinetics of Rosuvastatin and Simvastatin When Administered Alone or in Combination With Fostamatinib Completed Rheumatoid Arthritis NCT01725230
Simvastatin for Treating Erectile Dysfunction Completed Erectile Dysfunction|Vascular Disease Detected|C Reactive Protein NCT00947323
Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors Completed Retinoblastoma|Clear Cell Sarcoma|Renal Cell Carcinoma|Rhabdoid Tumor|Wilms Tumor|Hepatoblastoma|Neuroblastoma|Germ Cell Tumors|Ewings Sarcoma|Non-rhabdomyosarcoma Soft Tissue Sarcoma|Osteosarcoma|Rhabdomyosarcoma NCT02390843
Effects of Ezetimibe With Simvastatin in the Therapy of Adolescents With HeFH (Study P02579) Completed Hypercholesterolemia NCT00129402
Simvastatin and Fenofibrate vs Simvastatin Alone in Patients With Type 2 Diabetes Mellitus and Acute Coronary Syndrome Unknown status Acute Coronary Syndrome|Diabetes Mellitus, Type 2|Hypertriglyceridemia NCT02015988
The Effect of Simvastatin on Uterine Leiomyoma Development and Growth in Infertile Women Unknown status Infertility NCT03134157
The Effect of Multiple Oral Doses of BI 1356 BS on Pharmacokinetics, Safety and Tolerability of Multiple Oral Doses of Simvastatin and on the Pharmacokinetics of Its Metabolite Simvastatin Acid in Healthy Male Volunteers Completed Healthy NCT02183623
Effects on NF-ÎşB Activity: High Dose Simvastatin Versus Combination Therapy With Ezetimibe Completed Type 2 Diabetes|Inflammation NCT01424891
Simvatstatin Used to Treat Pulmonary Hypertension Unknown status Hypertension, Pulmonary NCT00538044
Simvastatin Effect on Inflammation and Endothelial Function After Myocardial Infarction Completed Myocardial Infarction|Inflammation|Endothelial Dysfunction NCT00906451
Effects of Simvastatin and Ezetimibe on Cardiovascular Risk Markers in Patients With Dyslipidemia Completed Dyslipidemia NCT02304926
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome Recruiting Noonan Syndrome NCT02713945
Simvastatin Effect on the Incidence of Acute Lung Injury/Adult Respiratory Distress Syndrome (ALI/ARDS) Withdrawn Adult Respiratory Distress Syndrome|Acute Lung Injury NCT01195428
A Pharmacokinetic Interaction Study Between TMC435, Atorvastatin and Simvastatin in Healthy Participants Completed Healthy Participants NCT01689623
Study To Assess the Pharmacokinetics of AZD1656 During Coadministration With Simvastatin Completed Type 2 Diabetes Mellitus NCT01096940
Comparing the Efficacy and Safety of Rosuvastatin With Atorvastatin and Simvastatin (SOLAR) Completed Hypercholesterolemia NCT00654173
Influence of Simvastatin on Apolipoprotein B-100 (apoB-100) Secretion Completed Hypercholesterolemia NCT00905541
The Additive Anti-inflammatory Effect of Simvastatin in Combination With Inhaled Corticosteroids in Asthma Completed Asthma NCT00792337
Oxidative Stress Lowering Effect of Simvastatin and Atorvastatin. Unknown status Diabetes Mellitus|Hypertension NCT00404599
A Study of the Efficacy and Safety of MK-0431D (a Fixed-dose Combination of Sitagliptin and Simvastatin) for the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-266) Terminated Type 2 Diabetes Mellitus NCT01678820
SIMOX - Induction of Oxidative Stress Completed Oxidative Stress NCT02256254
Phase II Study of Simvastatin for Relapsed/Refractory Myeloma Withdrawn Myeloma NCT01332617
IIIb 6 Week Open Label Multicentre Rosuvastatin & Simvastatin Completed Fredrickson Type IIa & Type IIb Dyslipidaemia NCT00654446
Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457) Completed Hypercholesterolemia NCT00653523
Effect of Simvastatin Withdrawal on Ocular Endothelial Function Withdrawn Healthy NCT02533141
A Research Study to Evaluate MK0653 (Ezetimibe) and Simvastatin, Given Together and Alone, on Intestinal Absorption of Cholesterol (0653-050)(COMPLETED) Completed Cholesterol NCT00652301
Drug-Drug Interaction Study Of Effect Of PF-03882845 On Simvastatin Pharmacokinetics Completed Human Volunteers NCT01445860
EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089) Completed Atherosclerosis NCT00166530
The Effects of Ezetimibe/Simvastatin 10/20 mg Versus Simvastatin 40 mg in High Cholesterol and Coronary Heart Disease Study (P04039AM2)(COMPLETED) Completed Hypercholesterolemia|Coronary Disease NCT00423579
Feasibility Study of Simvastatin in Hodgkin's Lymphoma Survivors Terminated Carotid Artery Disease NCT00746603
A Pharmacogenomics Study of Simvastatin-Induced Adverse Drug Reaction Recruiting Simvastatin Adverse Reaction|Pharmacogenomics|Accurate Medication NCT03261908
Investigation of Simvastatin in Secondary Progressive Multiple Sclerosis Completed Secondary Progressive Multiple Sclerosis NCT00647348
A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-line Chemotherapy in Metastatic Colorectal Cancer Patients Completed Colorectal Cancer NCT02026583
Effect of Simvastatin and Ezetimibe on Lipid and Inflammation Completed Prediabetes|Hypercholesterolemia|Inflammation|Cardiovascular Risk NCT01103648
Ezetimibe/Simvastatin (MK-0653A) Versus Rosuvastatin Versus Doubling Statin Dose in Participants With Cardiovascular Disease and Diabetes Mellitus (MK-0653A-133)(COMPLETED) Completed Cardiovascular Disorder|Diabetes Mellitus NCT00862251
A Drug Interaction Study Between Simvastatin, Atorvastatin, Rosuvastatin, and GSK2248761 in Healthy Subjects. Completed Infection, Human Immunodeficiency Virus NCT01138072
Trial to Evaluate the Efficacy of Simvastatin for Smoking Cessation Unknown status Smoking Cessation NCT02399709
Ezetimibe Plus Simvastatin Versus Simvastatin Alone in African-American Subjects With Primary Hypercholesterolemia (P03377) Completed Hypercholesterolemia|Atherosclerosis NCT00650663
A Randomized, Double-Blinded Study of Simvastatin 20 mg/Day Versus Vytorin 10/20 in Subjects With Lipid Profiles Not Meeting Current NCEP Guidelines, Following a Low-Carbohydrate Diet Completed Hyperlipidemia NCT00566267
Drug-drug Interaction of Empagliflozin (BI 10773) and Simvastatin Completed Healthy NCT01304329
Study About Simvastatin in Portal Hypertension in Compensated Cirrhosis Unknown status Portal Hypertension.|Liver Cirrhosis NCT01282398
The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast Cancer Recruiting Invasive Breast Carcinoma|Stage I Breast Cancer AJCC v7|Stage IA Breast Cancer AJCC v7|Stage IB Breast Cancer AJCC v7|Stage II Breast Cancer AJCC v6 and v7|Stage IIA Breast Cancer AJCC v6 and v7|Stage IIB Breast Cancer AJCC v6 and v7 NCT03454529
Statin Therapy Versus Placebo Prior to Prostatectomy Completed Cancer|Prostate Cancer NCT00572468
Evaluation of the Effects of Simvastatin 40mg Completed Hypercholesterolemia NCT00397826
A Single-centre Open Label Study to Investigate the Effect of Repeat Doses of SB-649868 on the Pharmacokinetics of Simvastatin and Atorvastatin in Healthy Male Volunteers. Completed Sleep Disorders NCT01299597
IMPROVE-IT: Examining Outcomes in Subjects With Acute Coronary Syndrome: Vytorin (Ezetimibe/Simvastatin) vs Simvastatin (P04103) Completed Hypercholesterolemia|Myocardial Infarction NCT00202878
High-dose Simvastatin for Aneurysmal Subarachnoid Haemorrhage Completed Subarachnoid Hemorrhage NCT01077206
Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-density Lipoprotein (LDL) Cholesterol Completed Hypercholesterolemia NCT00762164
Efficacy of Lapaquistat Acetate Alone or Combined With Simvastatin in Subjects With Hypercholesterolemia Completed Hypercholesterolemia NCT00286481
Safety and Tolerability Study of Ezetimibe (SCH 058235/MK-0653) Plus Atorvastatin or Simvastatin in Homozygous Familial Hypercholesterolemia (P01417/MK-0653-019) Completed Hypercholesterolemia NCT03885921
Statins To Treat Adult Cystic Fibrosis Withdrawn Cystic Fibrosis|Systemic Inflammation NCT01092572
Efficacy of Lapaquistat Acetate and Simvastatin in Subjects With Primary Dyslipidemia. Completed Hypercholesterolemia NCT00256178
Effects of Simvastatin on Biochemical Parameters and Outcome of IVF-ICSI in Pcos Patients Completed Polycystic Ovary Syndrome NCT00575601
Additive Effect of Ezetimibe Upon Simvastatin During Myocardial Infarction Completed Myocardial Infarction NCT00905905
Simvastatin Plus Rifaximin in Decompensated Cirrhosis Completed Cirrhoses, Liver NCT03150459
An Open-Label Extension to Assess the Continued Efficacy of Omacor Plus Simvastatin Unknown status Mixed Dyslipidemia NCT00678743
Irinotecan/Cisplatin With or Without Simvastatin in Chemo-naive Patients With Extensive Disease-small Cell Lung Cancer Recruiting Small Cell Lung Carcinoma NCT01441349
Simvastatin and Anastrozole in Treating Postmenopausal Women With Ductal Carcinoma In Situ or Invasive Breast Cancer Completed Breast Cancer NCT00354640
3Mixstatin ,Tri-Antibiotic Mix & Simvastatin in the Treatment of Primary Molars Not yet recruiting Tooth, Deciduous NCT03585751
Effect of Simvastatin on Pneumonia Prognosis in Elderly Patients Unknown status Community-Acquired Pneumonia NCT01651728
To Explore The Potential For PF-04531083 To Effect The Blood Concentrations Of Simvastatin And Its Main Acid Metabolite Following Co-Administration Of Both Medications Completed Chronic Pain NCT01103739
A Study of Aspirin and Simvastatin in Pulmonary Arterial Hypertension Terminated Hypertension, Pulmonary NCT00384865
BIBW 2992 Plus Simvastatin vs. BIBW 2992 in Previously Treated Patients With Advanced Non-adenocarcinomatous NSCLC Active, not recruiting Non-small Cell Lung Cancer NCT01156545
A Study to Determine the Effect of WelChol Tablets on Cholesterol in Patients Who Have Been Taking Simvastatin for at Least 4 Weeks. Completed Hypercholesterolemia NCT00753779
Effect of Simvastatin on Endothelial Function in Premenopausal Women With Systemic Lupus Erythematosus (0733-271)(TERMINATED) Terminated Systemic Lupus Erythematosus NCT00739050
Effect of Simvastatin on CF Airway Inflammation Completed Cystic Fibrosis NCT00255242
MK0524B Bioequivalence Study (0524B-070) Completed Dyslipidemia NCT00943124
Post-marketing Surveillance of the Safety, Tolerability and Efficacy of Vytorin (Ezetimibe + Simvastatin) Tablet Among Filipino Patients (Study P05647) Completed Hypercholesterolemia NCT00909389
Drug-Drug Interaction Study of Vadadustat With Rosuvastatin, Sulfasalazine, Pravastatin, Atorvastatin and Simvastatin Completed Drug Interaction Potentiation NCT03801733
Comparison of the Combination of Fenofibrate and 40 mg Simvastatin Versus 40 mg Simvastatin Monotherapy Completed Cardiovascular Diseases NCT00352183
Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery Recruiting Congenital Heart Disease|Heart Valve Disease NCT01653223
Trial of Simvastatin in Amnestic Mild Cognitive Impairment (MCI) Patients Active, not recruiting Mild Cognitive Impairment NCT00842920
Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy Volunteers Completed Cystic Fibrosis NCT00531882
Study of Heart and Renal Protection Completed Kidney Disease, Chronic NCT00125593
A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118) Terminated Primary Hypercholesterolemia|Dyslipidemia NCT01294683
Vascular Effects of Ezetimibe/Simvastatin and Simvastatin on Atherosclerosis Completed Atherosclerosis NCT00560170
The Effects of Simvastatin on Th17 Cytokines and Th17 Polarizing Cytokine in COPD Patients Completed COPD NCT01944176
Safety and Efficacy Study of JTT-705 in Combination With Simvastatin 40 mg in Patients With Low High-Density Lipoprotein (HDL) Levels Completed Dyslipidemia NCT00688558
Simvastatin Treatment of Patients With Acute Optic Neuritis Unknown status Optic Neuritis|Multiple Sclerosis NCT00261326
A Study To Estimate The Effect Of Repeated Dosing of PF-05175157 On The Pharmacokinetics Of A Single Dose Of Simvastatin In Healthy Adult Subjects Completed Type 2 Diabetes Mellitus NCT01469468
Hemodynamic Effect of Simvastatin With Beta Blockers in Clinical Portal Hypertension Unknown status Liver Cirrhosis|Portal Hypertension. NCT01282385
Gefitinib With or Without Simvastatin in Non-Small Cell Lung Cancer (NSCLC) Completed Lung Cancer NCT00452244
Simvastatin as Inhibitor of Cell Adhesion Mediated Drug Resistance in Patients With Refractory Multiple Myeloma. Completed Multiple Myeloma NCT00399867
Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients Recruiting Periodontal Diseases NCT03452891
Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial Completed Subarachnoid Haemorrhage NCT00731627
Antihypertensive Effect of Simvastatin in Hypertensive Patients Unknown status Hypertension NCT00704548
Does Simvastatin Affect Insulin Sensitivity in Dyslipidemic Type 2 Diabetic Patients? Completed Hypercholesterolemia|Diabetes|Cardiovascular Disease NCT00704314
A Drug-Drug Interaction Study of GK Activator (2) and Simvastatin in Patients With Type 2 Diabetes. Completed Diabetes Mellitus Type 2 NCT00377442
Comparison of the Combination of Fenofibrate and 20 mg Simvastatin Versus 40 mg Simvastatin Monotherapy Completed Hyperlipidemia NCT00349375
Evaluating Simvastatin's Potential Role in Therapy Completed Alzheimer Disease NCT00486044
Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin Completed Hypercholesterolemia|Dyslipidemia NCT00309738
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors Recruiting Advanced Pancreatic Cancer|Advanced Solid Tumor NCT03889795
Study to Compare the Efficacy and Safety of Pitavastatin and Simvastatin Completed Hypercholesterolemia|Dyslipidemia NCT00309777
PRC-4016 (Icosabutate) Phase I Drug-drug Interaction Study Completed Healthy NCT02367937
Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 a Subfraction of LDL in Patients With Metabolic Syndrome. Unknown status Metabolic Syndrome NCT00988364
Platelet Function in Diabetic Patients With and Without Renal Impairment, and the Effects of Lipid Lowering Treatment Completed Diabetes Mellitus|Renal Impairment NCT01035320
Simvastatin Therapy in Smith-Lemli-Opitz Syndrome Completed Smith-Lemli-Opitz Syndrome NCT00064792
Pharmacokinetic Drug Interaction Study of Dapagliflozin and Valsartan or Simvastatin in Healthy Subjects Completed Type 2 Diabetes Mellitus NCT00839683
The Effect Of Simvastatin On Bone Remodeling In Socket Of Mandibular Teeth Unknown status Hypercholesterolemia NCT01085149
Comparison of Co-administration of Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Primary Hypercholesterolemia (P03476) Completed Atherosclerosis|Hypercholesterolemia|Coronary Heart Disease NCT00651274
Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis Unknown status Renal Failure, End Stage|Peritoneal Dialysis NCT00291863
Mercury II - Compare the Efficacy and Safety of Lipid Lowering Agents Atorvastatin and Simvastatin With Rosuvastatin in High Risk Subjects With Type IIa and IIb Hypercholesterolemia Completed Hypercholesterolemia NCT00654407
An Evaluation of Simvastatin Plus Omacor Compared to Simvastatin Plus Placebo in Subjects With Mixed Dyslipidemia Completed Mixed Dyslipidemia NCT00487591
Comparison of Ezetimibe Plus Simvastatin Versus Ezetimibe or Simvastatin Alone in Subjects With Primary Hypercholesterolemia (Study P03757)(COMPLETED) Completed Hypercholesterolemia NCT00650819
Effects of Simvastatin Gel on Bone Neoformation in Post-extraction Sockets: a Randomized Controlled Trial Recruiting Alveolar Socket Preservation|Bone Regeneration NCT04149080
Study to Compare the Effect of Vytorin (Simvastatin/Ezetimibe) 10/20mg Versus Atorvastatin 20mg on ApoB/ApoA1 Ratio in Subjects With Diabetes Unknown status Type 2 Diabetes Mellitus Without Insulin Treatment NCT01185236
Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT) Unknown status Dyslipidemia|Atherosclerosis NCT00712049
Efficacy of Simvastatin for the Treatment of COPD Completed Chronic Obstructive Pulmonary Disease NCT02070133
Losartan and Simvastatin in Hypertensive Obeses With Liver Steatosis Unknown status Hypertension NCT00669435
Effect of Ezetimibe Plus Simvastatin on Flow-Mediated Brachial Artery Vasoactivity in Subjects With Primary Hypercholesterolemia (Study P03336) Terminated Hypercholesterolemia|Atherosclerosis NCT00651391
Simvastatin in Colorectal Surgery Completed Intestinal Neoplasm|Perioperative Care NCT00994903
Statin Distribution Completed Drug Distribution NCT02360826
Comparative Evaluation Of 1.2% Atorvastatin and 1.2% Simvastatin Gel Local Drug Delivery And Redelivery In Chronic Periodontitis Subjects With Diabetes Mellitus: A Randomized Controlled Clinical Trial. Completed Chronic Periodontitis Wth Diabetes Mellitus NCT03745300
Ezetimibe/Simvastatin (10 mg/40 mg) vs. the Doubling of Atorvastatin in High Risk Participants (MK-0653A-134 AM1)(COMPLETED) Completed Hypercholesterolemia NCT00782184
Simvastatin as an Add-on Treatment to Interferon-beta-1a for the Treatment of Relapsing-Remitting Multiple Sclerosis Completed Multiple Sclerosis NCT00492765
Simvastatin in Preventing Liver Cancer in Patients With Liver Cirrhosis Recruiting Cirrhosis NCT02968810
A Drug-Drug Interaction Study Between GDC-0853 and Midazolam, Itraconazole, Rosuvastatin, and Simvastatin Completed Healthy Participants NCT03174041
Comparison of the Combination of Fenofibrate and Simvastatin Versus Atorvastatin Completed Hyperlipidemia NCT00362934
Ezetimibe and Simvastatin in Primary Hypercholesterolemia, Diabetes Mellitus Type 2, and Coronary Heart Disease (COMPLETED) Completed Hypercholesterolemia|Diabetes Mellitus, Type 2|Coronary Disease NCT00423488
Antiplatelet and Anti-inflammatory Effects of Statins and Ezetimibe Completed Stable Angina NCT00474123
Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578) Completed Atherosclerosis|Hypercholesterolemia|Hyperlipoproteinemia Type II NCT00552097
Efficacy and Safety of Simvast Controlled Release (CR) and Zocor in Chronic Kidney Disease(CKD) Stage 3, 4 and 5 Patients With Hyperlipidemia Unknown status Chronic Kidney Disease|Hyperlipidemia NCT01564875
Phase II Study of Simvastatin in Primary Breast Cancer; Test of Its Potential Selectivity on Basal Subtype Breast Cancer Unknown status Breast Cancer NCT00807950
Simvastatin Treatment of Pachyonychia Congenita Unknown status Pachyonychia Congenita NCT01382511
Comparison of the Combination of Fenofibrate and Simvastatin Versus Pravastatin Completed Hyperlipidemia NCT00362206
A Study to Investigate the Effect of MT-8554 on the Pharmacokinetics of Simvastatin and Rosuvastatin in Healthy Subjects Completed Healthy NCT02675309
Ezetimibe/Simvastatin Combination in Proteinuric Nephropathy Unknown status Hypercholesterolemia|Chronic Nephropathy NCT00861731
Simvastatin For Intracerebral Hemorrhage Study Terminated Intracerebral Hemorrhage NCT00718328
A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol Terminated Elevated LDL Cholesterol NCT01004705
Ezetimibe (+) Simvastatin vs. Atorvastatin Comparative Study in DM or Metabolic Syndrome Patients (0653A-093) Completed Hypercholesterolemia NCT00157924
Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL Cholesterol Terminated Elevated LDL Cholesterol NCT01362218
Simvastatin Therapy in Women With Polycystic Ovary Syndrome. Completed Polycystic Ovary Syndrome NCT00365638
1.2% Atorvastatin and 1.2% Simvastatin in Treatment of Chronic Periodontitis Completed Chronic Periodontitis NCT02060032
Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes Completed Type 2 Diabetes NCT00471549
Efficacy and Safety of Valsartan and the Combination of Valsartan and Simvastatin Completed Hypertension|Hypercholesterolemia|Dyslipidemia NCT00385931
Effect of Simvastatin on Cardiac Function Completed Rheumatic Heart Disease|Congenital Heart Disease|Aneurysm|Heart Valve Disease NCT01178710
Simvastatin as an add-on Treatment to Copaxone for the Treatment of Relapsing Multiple Sclerosis Withdrawn Relapsing Remitting Multiple Sclerosis NCT00429442
Ezetimibe Plus (+) Simvastatin Versus Atorvastatin Comparative Study (0653A-092)(COMPLETED) Completed Hypercholesterolemia NCT00166504
Study to Evaluate the Effect of Simvastatin, Losartan and Pioglitazone on Patients With Peripheral Arterial Disease. Completed Peripheral Arterial Disease NCT00720577
A Drug Interaction Study Between Tocilizumab, Methotrexate and Simvastatin on Patients With Rheumatoid Arthritis. Completed Rheumatoid Arthritis NCT00365001
To Compare the Efficacy and Safety of Carvedilol With or Without Simvastatin in Patients With Portal Hypertension and Esophageal Varices. Completed Cirrhosis With Esophageal Varices NCT02465645
Statin Therapy in the Treatment of Sepsis Completed Septic Shock NCT00676897
A Randomized, Double-Blind, Placebo-Controlled Trial of Simvastatin on Subarachnoid Hemorrhage-Induced Vasospasm Completed Subarachnoid Hemorrhage|Delayed Vasospasm NCT00235963
Efficacy And Safety Study Of Atorvastatin Versus Simvastatin In Type 2 Diabetic Subjects With Hypercholesterolemia Completed Hypercholesterolemia NCT00141141
Efficiency of Rosuvastatin Versus the Fixed Combination of Ezetimibe/Simvastatin in Outpatients Completed Dyslipidemia NCT01164397
Effect Of Ezetimibe Coadministration With Simvastatin In A Middle Eastern Population: A Prospective, Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial (0653-151) Completed Hypercholesterolemia NCT00652444
A Study to Assess the Safety and Tolerability of Sitagliptin/Simvastatin Fixed-dose Combination (FDC) in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-312) Completed Type 2 Diabetes Mellitus NCT01702298
A 10-12 Week Study to Evaluate the Safety and Efficacy of 320 mg Valsartan and 80 mg Simvastatin in Combination and as Monotherapies in Treating Hypertension and Hypercholesterolemia Completed HYPERTENSION|HYPERCHOLESTEROLEMIA NCT00171093
Follow-on Protocol of Pitavastatin Versus Simvastatin in Patients With Hypercholesterolemia or Dyslipidemia and Coronary Heart Disease Risk Factors Completed Hypercholesterolemia|Dyslipidemia|Coronary Heart Disease NCT00344175
Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic Pancreatitis Active, not recruiting Acute Pancreatitis NCT02743364
The Acute Effect of Statins on Inflammatory Markers of Athersclerotic Tissue Completed Carotid Artery Disease NCT00587717
Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study Completed Polycystic Ovary Syndrome NCT01021579
Platelet Rich Fibrin Combined With Simvastatin for Treatment of Intrabony Defect in Chronic Periodontitis Completed Three Wall Intrabony Defects in Chronic Periodontitis NCT02120872
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC Completed Colorectal Cancer|Metastasis NCT00313859
Simvastatin in Patients With Septic Shock Unknown status Septic Shock NCT00450840
A Study for Pre-diabetic Patients With Cholesterol Lowering Drugs Completed Pre-diabetes NCT00831129
A Study to Evaluate the Efficacy of Valsartan/Simvastatin Combinations in Patients With Both Essential Hypertension and Hypercholesterolemia Completed Essential Hypertension|Hypercholesterolemia NCT00254475
Ezetimibe (SCH 58235) Taken With Either Atorvastatin or Simvastatin in Participants With Familial Hypercholesterolemia (MK-0653-018) Completed Familial Hypercholesterolemia NCT03884452
Irinotecan/Cisplatin Plus Simvastatin in Extensive Disease-Small Cell Lung Cancer (ED-SCLC) Completed Small Cell Lung Cancer NCT00452634
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH Completed Cardiovascular Diseases|Heart Diseases|Coronary Disease|Atherosclerosis|Myocardial Infarction NCT00880178
Cardiovascular Events Based On Statin Initiation In The Elderly Completed Cardiovascular|Dyslipidemia NCT01304641
A 12-week Study to Compare the Efficacy and Safety of Fixed Combinations of Fenofibrate/Simvastatin 145/20mg and Fenofibrate/Simvastatin 145/40mg Tablets Versus Fenofibrate or Simvastatin Monotherapies in Subjects With Abnormal Blood Levels of Fats (Lipids) and at High Risk of Cardiovascular Disease Completed Dyslipidemia NCT01674712
Effect of Diabetes Mellitus on Cholesterol Metabolism Completed Type 1 Diabetes Mellitus|Type 2 Diabetes Mellitus|Hypercholesterolemia NCT00879710
Efficacy and Safety of Extended-Release Niacin/ Laropiprant/Simvastatin Tablets in Participants With Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-143) Terminated Primary Hypercholesterolemia|Mixed Dyslipidemia NCT01335997
To Evaluate the Lipid-Lowering Efficacy and Safety of Simvastatin 40 Mg Tablet In Patients With Hypercholesterolemia (0733-264) Completed Hypercholesterolemia NCT00398294
EARLY IFNB-1a and Simvastatin Combination Therapy in Clinically Isolated Syndrome Suggestive of Multiple Sclerosis Completed Multiple Sclerosis NCT00146068
The Effect of High Dose Simvastatine on Multiple Myeloma Completed Multiple Myeloma NCT00281476
Efficacy and Safety of Simvastatin in the Treatment of Portal Hypertension Completed Cirrhosis|Portal Hypertension NCT00594191
Detection of Plaque Inflammation by Positron Emission Tomography (PET)-Effects of Simvastatin on Plaque Inflammation Completed Atherosclerosis NCT00114504
An Open-Label Study to Compare the Lipid Effects of Niacin ER and Simvastatin (NS) to Atorvastatin in Subjects With Hyperlipidemia or Mixed Dyslipidemia (SUPREME) Completed Hyperlipidemia|Mixed Dyslipidemia NCT00465088
To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patients With Type IIa or Type IIb Hyperlipidemia (0653A-091)(COMPLETED) Completed Hypercholesterolemia NCT00271817
Simvastatin Reduces Adiponectin Levels and Insulin Sensitivity Completed Hypercholesterolemia NCT00546182
Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS) Completed Hypercholesterolemia NCT00080275
Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD Completed Cardiovascular Diseases NCT00159835
Safety & Efficacy of a Combination Niacin ER/Simvastatin in Patients With Dyslipidemia: A Dose-Ranging Study - SEACOAST Completed Hypercholesterolemia NCT00082251
Efficacy and Safety Study of MCI-196 Versus Simvastatin for Dyslipidaemia in Chronic Kidney Disease (CKD) Subjects on Dialysis Completed Chronic Kidney Disease NCT00858637
STELLAR-Rosuvastatin vs. Atorvastatin, Pravastatin, Simvastatin Across Dose Ranges Completed Hypercholesterolemia NCT00654537
Effect of Statin Treatment on Insulin Sensitivity During Myocardial Infarction Completed Myocardial Infarction NCT01205347
Simvastatin and Metformin Therapy in PCOS Women. Prospective Randomised Trial. Unknown status Polycystic Ovary Syndrome NCT00396513
Efficacy of Fluvastatin and Fenofibrate in Comparison to Simvastatin and Ezetimibe in Patients With Metabolic Syndrome Completed Dyslipidemia NCT00385658
Ezetimibe/Simvastatin in Patients With Metabolic Syndrome (0653A-107)(COMPLETED) Completed Hypercholesterolemia|Metabolic Syndrome NCT00409773
Evaluate Safety and Efficacy of ABT-335 in Combination With Simvastatin in Subjects With Multiple Abnormal Lipid Levels in the Blood Completed Dyslipidemia|Coronary Heart Disease|Mixed Dyslipidemia NCT00300456
Simvastatin and Panitumumab in Treating Patients With Advanced or Metastatic Colorectal Cancer Unknown status Colorectal Cancer NCT01110785
LDL Receptor Under Ezetimibe and Simvastatin Completed Healthy Men NCT00317993
A Two-part Study to Investigate the Interaction and Pharmacokinetics of GSK2586184 Completed Systemic Lupus Erythematosus NCT01953835
Ezetimibe and Simvastatin in Dyslipidemia of Diabetes Completed Type 2 Diabetes NCT00157482
Cetuximab and Simvastatin in Treating Patients With Advanced or Metastatic Colorectal Cancer Unknown status Colorectal Cancer NCT01190462
Combination of Telmisartan and Simvastatin in the Treatment of Hypertension and Hypercholesterolemia Completed Hypertension|Dyslipidemias NCT00316095
Study Evaluating the Efficacy and Safety of Simvastatin Alone Compared With Simvastatin Plus Ezetimibe in Type 2 Diabetic Patients (0653-021)(COMPLETED) Completed Diabetes Mellitus, Type 2 NCT00551876
A Study Comparing Ezetimibe Plus Simvastatin Versus Simvastatin Alone in Patients at Risk for Heart Disease (0653-023)(COMPLETED) Completed Coronary Disease NCT00551447
Protocol for Correlating Enteropathic Severity and Small Intestinal CYP3A4 Activity in Patients With Celiac Disease Completed Celiac Disease NCT01338324
Pleiotropism of Statin Therapy in High Dose Versus Low Dose Combined With Ezetimibe Unknown status Endothelial Function NCT01241097
MK-0524B Lipid Study (MK-0524B-063) Completed Primary Hypercholesterolemia|Mixed Dyslipidemia NCT00479882
Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins Completed Cavernous Angioma, Familial|Cerebral Cavernous Malformations|Cerebral Cavernous Hemangioma NCT01764451
Vascular and Metabolic Effects of Vytorin vs Simvastatin Completed Hypercholesterolemia NCT01666067
Targeting Sympathetic Overactivity in Heart Failure Patients With Statins Completed Heart Failure NCT01097785
Cardio Risk of Acute Schizophrenia Olanzapine Duke Withdrawn Schizophrenia|Schizoaffective Disorder NCT00672464
Efficacy Study of Oral L-Citrulline in Patients Taking Simvastatin With Peripheral Arterial Disease Unknown status Peripheral Arterial Disease|Intermittent Claudication NCT00351286
A Drug Interaction Study Between Simvastatin and GSK376501 Completed Type 2 Diabetes Mellitus NCT00605449
Role of Anti-Inflammatory Agents in Patients With Schizophrenia Completed Schizophrenia|Schizoaffective Disorder|Psychosis Not Otherwise Specified|Schizophreniform Disorder NCT00929955
Living With Statins - Interventional Exercise Study Unknown status Cardiovascular Disease|Diabetes Mellitus NCT02796378
A Study to Assess the Cholesterol Lowering Effect of an Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Patients With High Cholesterol and With High Cardiovascular Risk (0653A-809)(COMPLETED) Completed Hypercholesterolemia NCT00479713
Efficacy of Statin Association With Standard Treatment in Prevention of Recurrent Hemorrhage in Patient With Cirrhosis and Variceal Bleeding Completed Cirrhosis|Hypertension, Portal|Bleeding Esophageal Varices|Portal Vein Thrombosis NCT01095185
Ezetimibe Plus Simvastatin Versus Simvastatin in Patients With Hypercholesterolemia and Coronary Risk Factors (P03405) Terminated Hypercholesterolemia|Atherosclerosis NCT00651014
Hypolipemic Treatment in Acute Coronary Syndrome (ACS): Antithrombotic Effects Unknown status Acute Coronary Syndrome NCT00725829
Ezetimibe-Simvastatin Evaluation Study Not yet recruiting Hypercholesterolemia|Hyperlipidemias|Statin Monotherapy Response NCT03947866
PROMISS: Simvastatin Prevents the Contrast Induced Acute Renal Failure in Patients With Renal Insufficiency Undergoing Coronary Angiography Completed Kidney Failure NCT00259441
Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery Completed Perioperative Inflammatory Response NCT00656292
A Study to Assess the Cholesterol Lowering Effect of Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Elderly Patients With High Cholesterol at High or Moderately High Risk for Coronary Heart Disease (0653A-128) Completed Hypercholesterolemia NCT00535405
Effects on Atherosclerosis Regression of Ezetimibe or Ezetimibe Plus Simvastatin; Evaluated by Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Withdrawn Atherosclerosis NCT00926055
Endothelial Facilitation in Alzheimer's Disease Completed Alzheimer's Disease NCT01439555
Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy Completed Oxidative Stress|Diabetic Polyneuropathy NCT02129231
Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease Completed Alzheimer's Disease NCT00939822
NIRS to Diagnose SAMS Active, not recruiting Statin Adverse Reaction|Skeletal Myopathy NCT03653663
Simvastatin in Patients With Isolated Arterial Hypertension Unknown status Hypertension NCT01017835
Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy) Completed Coronary Artery Disease|Carotid Artery Diseases|Atherosclerosis NCT01178320
Impact of Statins on Cytokine Expression in Pneumonia Withdrawn Community Acquired Pneumonia|Cardiovascular Risk Factors NCT00946166
Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level Unknown status Systemic Lupus Erythematosus|High LDL Cholesterol Level NCT00866229
Living With Statins - The Impact of Cholesterol Lowering Drugs on Health, Lifestyle and Well-being Completed Cardiovascular Disease|Diabetes Mellitus NCT02255682
A Study of MK0653A (Ezetimibe (+) Simvastatin) in Patients With Hypercholesterolemia (0653A-038) Completed Hypercholesterolemia NCT00092651
Monocyte Function and Inflammation in Type 1 Diabetes and Its Modulation Completed Type 1 Diabetes NCT00441844
Effect of Acute Statin Treatment in Patients Undergoing Percutaneous Coronary Intervention Terminated Coronary Artery Disease NCT00588471
Efficacy/Safety of Rosuvastatin+Ezetimibe in High Risk Patients With Primary Hypercholesterolemia/Mixed Dyslipidemia Completed Hypercholesterolemia|Dyslipidemia NCT01420549
A Study to Evaluate the Effects of ASA404 Alone or in Combination With Taxane-based Chemotherapies on the Pharmacokinetics of Drugs in Patients With Advanced Solid Tumor Malignancies Terminated Solid Tumor Malignancies NCT01290380
A Safety Study of Combination Treatment With Avonex and Zocor in Relapsing Remitting Multiple Sclerosis Unknown status Relapsing Remitting Multiple Sclerosis NCT00242268
Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH) Completed Subarachnoid Hemorrhage NCT00795288
A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol. Completed Hyperlipidemia|Dyslipidemia|Hypercholesterolemia NCT00267254
15-Day Repeated-Dose Study With SB-649868 And Its Interaction With CYP3A4 Isoenzyme In Healthy Male Subjects. Completed Sleep Initiation and Maintenance Disorders NCT00495729
A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol (A5091031). Terminated Hyperlipidemia|Dyslipidemia|Hypercholesterolemia NCT00267280
Statin/Vitamin D & Migraine Study Completed Migraine NCT01225263
Cholesterol Lowering Agent to Slow Progression (CLASP) of Alzheimer's Disease Study Completed Alzheimer Disease NCT00053599
Do HMG CoA Reductase Inhibitors Affect Abeta Levels? Completed Alzheimer's Disease|Aging NCT00303277
A Crossover Study to Evaluate the Efficacy of Simvastatin in Elevating HDL-C Levels in Patients With Type 2 Diabetes (0733-216)(COMPLETED) Completed HDL Cholesterol NCT00389896
Safety, Pharmacokinetics and Pharmacodynamics of LGT209 in Healthy Volunteers With Elevated Cholesterol and in Hypercholesterolemic Patients Treated With Statins Completed Hypercholesterolemia|LDL Cholesterol NCT01859455
Effect of Statin Therapy on C-Reactive Protein Levels in Patients With Chronic Obstructive Lung Disease (COPD) Unknown status COPD|Inflammation NCT00655993
Simvastatin in Relapsing Remitting Multiple Sclerosis (RRMS) Patients Using Avonex Compared to Placebo Completed Relapsing Remitting Multiple Sclerosis NCT00668343
Differential Metabolic Effects of Statins Completed Hypercholesterolemia NCT00546559
A Clinical Trial Comparing Torcetrapib/Atorvastatin to Ezetimibe/Simvastatin In Subjects With A Cholesterol Disorder. Terminated Hyperlipidemia|Dyslipidemia NCT00267267
MK0653A (Ezetimibe (+) Simvastatin) Compared to an Approved Drug (Atorvastatin) for the Treatment of High Cholesterol (0653A-051)(COMPLETED) Completed Hypercholesterolemia NCT00092690
Intensive Statin Therapy in Patients With AMI Unknown status Acute Myocardial Infarction NCT01923077
STATIN-VAP STATIN-VAP - STATINs and Ventilator-Associated Pneumonia Terminated Pneumonia NCT01057758
Anti-Platelet and Statin Therapy to Prevent Cancer-Associated Thrombosis Completed Solid Tumor|Cancer NCT02285738
Muscle Characteristics Associated With Statin Therapy Withdrawn Hydroxymethylglutaryl-CoA Reductase Inhibitors|Myopathy NCT00990834
Begin With The Right Patients With Dual-Inhibition Action Therapy Through Vytorin for Newly Diagnosed Dyslipidemia Patients (0653A-172)(COMPLETED) Completed Hypercholesterolemia NCT00654628
The Effect of Statins in Patients With Chronic Obstructive Pulmonary Disease (COPD) Completed Chronic Obstructive Pulmonary Disease NCT01151306
Effect of Ezetimibe on Platelet Aggregation and LDL Tendency to Peroxidation Completed Hypercholesterolemia NCT00466401
The Effects of Hypolipemic and Antidiabetic Treatment on Cytokines Unknown status Diabetes|Dyslipidemia|Inflammation|Cytokines NCT01101204
Effect of Vitamin D Supplementation on Exercise Adaptations in Patients on Statin Therapy Completed Dyslipidemias NCT02030041
Efficacy and Safety of Morning Versus Evening Intake of Simvast Controlled Release (CR) Tablet in Patients With Hyperlipidemia Completed Hyperlipidemia NCT00973115
GSK2647544 RD, DDI in Healthy Young and Elderly Volunteers Terminated Alzheimer's Disease NCT01978327
Crossover of Higher Dose Statins in Patients With Low High-density Lipoproteins Cholesterol (HDLc) Unknown status HDL Cholesterol NCT00736463
Lipid-lowering Therapies in Vietnamese Chronic Kidney Disease Population Recruiting Hypercholesterolemia|Chronic Kidney Diseases NCT03543774
Assessment of Interaction Between Vytorin and Niaspan in Healthy Subjects (P04955AM2) Completed Hypercholesterolemia|Hyperlipidemia NCT00652431
Statin Therapy Vs. Therapeutic Lifestyle Changes and Supplements Completed Hyperlipidemia NCT00365742
Effect of Statin Use on Aldosterone Secretion Recruiting Healthy Subjects NCT02871687
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TAP311 in Healthy Subjects and Dyslipidemic Patients Completed Dyslipidemia|Healthy Volunteers NCT01487460
Pharmacokinetic and Safety Study of Cenicriviroc and HMG-CoA Reductase Inhibitors, Caffeine and Digoxin Completed Healthy NCT02685462
Diabetes and Combined Lipid Therapy Regimen (DIACOR) Study Completed Type II Diabetes Mellitus|Mixed Dyslipidemia NCT00309712
Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons Completed Coronary Heart Disease NCT00481351
Vytorin Treating Uncontrolled Lipids (VyTUL) Study (0653A-122) Terminated Cardiovascular Diseases|Diabetes Mellitus NCT00395603
Ezetrol Post-Marketing Study Completed Hyperlipidemia NCT00753883
Pharmacodynamic Drug Interaction Between Cilostazol and Statins Completed Healthy NCT01870466
A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Blood Pressure Terminated Hypertension NCT01005290
Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir Combination Completed Chronic Hepatitis c|Metabolic Syndrome NCT03490097
An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED) Completed Aortic Stenosis NCT00092677
Early Effects of Intensive Lipid Lowering Treatment With Ezetimibe/ Simvastatin (Vytorin®) Assessed by Virtual Histology-Intravascular Ultrasound (VH-IVUS) and Optical Coherence Tomography (OCT) on Plaque Characteristics in Patients With Acute Coronary Syndrome Completed Acute Coronary Syndrome NCT01857843
Vytorin on Carotid Intima-media Thickness and Overall Rigidity Completed Cardiovascular Diseases NCT00738296
A Study of the PK Interaction of CXA-10 With Pravastatin and Vytorin® in Healthy Males Completed Acute Kidney Injury NCT02547402
Left Ventricular Hypertrophy Reduction With Statins in Hypertensives Patients (MK0653A-168) Terminated Hypertension NCT00738972
12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With Ezetimibe Completed Hypercholesterolemia|Coronary Heart Disease|Atherosclerosis NCT00525824
A Study To Evaluate The Safety And Tolerability Of SB-656933-AAA Following Repeated Doses In Healthy Adult Subjects Completed Pulmonary Disease, Chronic Obstructive NCT00504439
A Prevention Trial in Subjects at High Risk for Breast Cancer Completed Breast Cancer NCT01500577
Study To Assess The Efficacy Of A Cholesterol Lowering Drug On Top Of Statins In Patients After Myocardial Infarction (MI)(0653A-150) Completed Cardiovascular Disorder NCT00652717
Cholesterol Lowering Level of MK0653A+Simvastatin in Patients With Hypercholesterolemia and Atherosclerotic or Coronary Vascular Disease (0653A-806)(COMPLETED) Completed Hypercholesterolemia|Atherosclerotic Disease|Coronary Disease NCT00090168
Acetyl-L-Carnitine in Type 2 Diabetes Completed Diabetes Type 2|Hypertension NCT00984750
A Study of LY2484595 in Patients With High LDL-C or Low HDL-C Completed Dyslipidemia NCT01105975
Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins Completed Atrial Fibrillation NCT00321802
Treatment of HDL to Reduce the Incidence of Vascular Events HPS2-THRIVE Completed Cardiovascular Disease|Peripheral Arterial Disease|Diabetes Mellitus|Coronary Heart Disease NCT00461630
A Randomized, Double-Blind, Placebo-Controlled Study to Examine the Effect of Betahistine on Plasma Lipids in Patients Treated With Simvastatin Terminated Hypercholesterolemia NCT00466869
Registry On Efficacy and Safety Of Rosuvastatin, and Atorvastatin and Simvastatin In Hypercholesterolaemia Completed Hypercholesterolaemia NCT01352897
Effectiveness of Two Approved Drugs in Lowering High Cholesterol (0733-224) Completed Hypercholesterolemia NCT00092157
Targeting Microvascular Dysfunction in Young Hypertensive Patients Withdrawn Hypertension NCT01047423
A Study to Evaluate an Investigational Drug in Patients With Mixed Hyperlipidemia (0653A-071)(COMPLETED) Completed Hyperlipidemia|Hypercholesterolemia|Hypertriglyceridemia NCT00093899
Cellular Effect of Cholesterol-Lowering Prior to Prostate Removal Completed Prostate Cancer NCT02534376
Lipid Efficacy and Safety in Participants With Mixed Hyperlipidemia (MK-0524B-024) Completed Mixed Hyperlipidemia NCT00289900
Renal Hemodynamic Effects of the HMG-CoA Reductase Inhibitors in Normal Volunteers and in Patients With Chronic Renal Failure Completed Hyperlipidemia|Hypertension|Chronic Renal Failure NCT02511418
An Observational Follow-Up Study of the Incidence of Cancer and Mortality in Patients From the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) Trial (MK-0653A-043-10) Completed Cancer NCT01077830
Cholesterol and Pharmacogenetic Study Completed Hyperlipidemia|Hypercholesterolemia|Coronary Heart Disease|Cardiovascular Disease NCT00451828
An Extension Study of An Investigational Drug in Patients With Hypercholesterolemia (0653A-038)(COMPLETED) Completed Hypercholesterolemia NCT00092664
CoEnzyme Q10 in Statin Myopathy Unknown status Statin Myopathy NCT01140308
Niacin Plus Statin to Prevent Vascular Events Terminated Cardiovascular Diseases|Heart Diseases|Cerebrovascular Accident|Coronary Disease|Atherosclerosis|Myocardial Infarction NCT00120289
Metabolic and Vascular Effects of Statins in Untreated Dyslipidemic Diabetic Patients Completed Type 2 Diabetes|Diabetic Dyslipidemia NCT00854503
Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine Completed Cardiovascular Disease NCT00124072
Effects of Statins on Pro- and Antioxidant Status : Link With Statin-Associated Myopathy. Completed Healthy NCT00285181
Randomized Double Blind Placebo Control Study in Patients With Schizophrenia Completed Schizophrenia|Schizoaffective Disorder|Psychosis Not Otherwise Specified|Schizophreniform Disorder NCT01602029
Effects of Statins on the Pharmacokinetics for Midazolam in Healthy Volunteers Completed Healthy Volunteers NCT00716846
Effect of Enhanced External Counterpulsation (EECP) on Subclinical Atherosclerosis Unknown status Atherosclerosis NCT01106495
Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both Completed Cholesterol, LDL NCT00461968
Comparison of Ezetimibe Added to Ongoing Statin Therapy Versus Doubling the Dose of Statin in the Treatment of Hypercholesterolemia (P04355) Completed Hypercholesterolemia NCT00652327
Effects of Vytorin Versus Placebo in Subjects With Primary Hypercholesterolemia (Study P04420) Completed Hypercholesterolemia NCT00413972
Efficacy and Safety of Statin on the Course of Progressive Smoldering Multiple Myeloma Withdrawn Smoldering Multiple Myeloma NCT00503763
Aggrastat to Zocor (AtoZ) - the Use of Two Approved Drugs to Treat Patients Who Have Experienced Chest Pain or a Heart Attack (0733-180) Completed Acute Coronary Syndrome NCT00251576
The Evening Versus Morning Polypill Utilization Study Completed Cardiovascular Disease|Cerebrovascular Disease|Peripheral Arterial Disease NCT01506505
Methotrexate and Statins With Methotrexate Alone in the Treatment of Rheumatoid Arthritis Completed Arthritis, Rheumatoid NCT04177173
A Multiple-dose Study of LY3031207 in Healthy Participants Terminated Healthy Volunteers NCT01632566
A Year 2, Safety Extension Study of the Combination of ABT-335 and Statin Therapy for Subjects With Mixed Dyslipidemia Completed Mixed Dyslipidemia NCT00491530
Role of Immune Responses After Acute Myocardial Infarction Unknown status Myocardial Fibrosis NCT02428374
Carotid Atherosclerosis Regression at Magnetic Resonance Assessment. Completed Established Carotid Atherosclerosis NCT00307307
Eze/Simva Switch Study in Diabetics (0653A-807) Completed Diabetes Mellitus, Type 2 NCT00541697
Study to Evaluate the Cholesterol Lowering Effects of Two Marketed Drugs in Patients With Elevated Cholesterol Levels (0653A-058) Completed Hypercholesterolemia NCT00090298
Reduction in YEllow Plaque by Aggressive Lipid LOWering Therapy Completed Coronary Artery Disease NCT01567826
To Study the Effect of Vytorin on Intracellular Lipid and Inflammation in Obese Subjects Unknown status Inflammation NCT01420328
Microcirculation In Acute Coronary Syndromes Unknown status ST Elevation (STEMI) Myocardial Infarction NCT01382472
Drugs for High Blood Pressure and High Cholesterol in American Indians With Type 2 Diabetes Completed Diabetic Nephropathy NCT00004266
Effects of Achieving Very Low LDL-Cholesterol After Treatment With Statins on Steroidogenesis and Cognition Completed Type 2 Diabetes Mellitus|Cardiovascular Disease|LDL Cholesterol|Cognition NCT00522158
Effects of Angiotensin II Receptor Blocker Compared With Diuretics in High-risk Hypertensive Patients Unknown status Essential Hypertension NCT01011660
A Drug-Drug Interaction Study of Lanabecestat (LY3314814) in Healthy Participants Completed Healthy NCT02406261
Merck Carotid Atherosclerosis Trial (MK-0000-111)(COMPLETED) Completed Carotid Atherosclerosis NCT00804843
A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin® 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea (0653A-129)(COMPLETED) Completed Hypercholesterolemia NCT00496730
Vytorin As Strategy To Reduce Dislipidemia In Adults (0653A-148) Completed Hyperlipidemia NCT00651560
Study of Extended Release Niacin/Laropiprant on Lipids (0524A-067) Completed Primary Hypercholesterolemia|Mixed Dyslipidemia NCT00479388
Primary Prevention of Cardiovascular Disease (CVD) in Pre-diabetic & Pre-hypertensive Subjects Unknown status Pre-diabetes|Pre-hypertension NCT01364675
The Effect of Providing Free Samples of Generic Cardiovascular Medications to Physicians Unknown status Hypertension|Hyperlipidemia NCT00761904
A Multicenter Study to Evaluate the Cholesterol Lowering Effects of Two Marketed Products in Patients With Type 2 Diabetes Mellitus and Hypercholesterolemia (MK-0653A-077) Completed Type 2 Diabetes Mellitus|Hypercholesterolemia NCT00110435
Ezetimibe and Statins on Postprandial Lipemia in Type 2 Diabetes Completed Postprandial Lipemia|Type 2 Diabetes NCT00699023
Acupuncture and Moxibustion for Hyperlipemia Unknown status Hyperlipidemias NCT02269046
Pioglitazone in Impaired Glucose Tolerance Withdrawn Glucose Metabolism Disorders NCT00306826
A Study of Evacetrapib With Selected Statins in Healthy Chinese Participants Completed Healthy Volunteers NCT02156492
Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients Active, not recruiting Serious Mental Illness|Schizophrenia|Schizoaffective Disorder|Bipolar Disorder|Cardiovascular Disease|Major Depressive Disorder|Psychosis NOS NCT02188121
Statins for the Early Treatment of Sepsis Terminated Sepsis NCT00528580
A Study to Determine the Number of Patients Who Reach Optimal Cholesterol Levels on Each of Three Different Treatments (0653A-121) Completed Hypercholesterolemia NCT00462748
Comprehensive Magnetic Resonance of Peripheral Arterial Disease Completed Peripheral Artery Disease NCT00587678
Standard Medical Management in Secondary Prevention of Ischemic Stroke in China Completed Stroke NCT00664846
Study to Evaluate the Long-Term Safety and Efficacy of ABT-335, in Combination With Three Different Statins in Subjects With Mixed Dyslipidemia. Completed Dyslipidemia|Coronary Heart Disease|Mixed Dyslipidemia NCT00300430
Effects of Omega-3 Fatty Acids on Platelets in Patients With Coronary Artery Disease With Hypertriglyceridemia Unknown status Coronary Artery Disease NCT01086163
Exercise, Statins, and the Metabolic Syndrome Completed Metabolic Syndrome|Obese|Sedentary NCT01700530
Fixed Dose Combination Drug (Polypill)for Secondary Cardiovascular Prevention. Completed Myocardial Infarction NCT01321255
DNA Diagnostic System for Statin Safety and Efficacy Unknown status Hypercholesterolemia|Myopathy NCT00767130
A Study to Evaluate the Efficacy and Safety of Vytorin Versus Standard Treatment of Other Statins in Moderate, Moderately High and High Risk Participants (MK-0653A-406) Withdrawn Dyslipidemia NCT01587235
Transesophageal Magnetic Resonance Imaging (MRI) in Conjunction With Lipid Lowering Measures Completed Heart Diseases NCT00125060
Therapeutic Effects of Compound Zhenzhu Tiaozhi Capsules in NAFLD Unknown status Nonalcoholic Fatty Liver Disease NCT03375580
Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER) Completed Transient Ischemic Attack|Stroke NCT00109382
Vytorin (10/20 Or 10/40) Compared to Atorvastatin (10 mg or 20 mg) in Patients With Coronary Artery Disease (0653A-126)(COMPLETED) Completed Hypercholesterolemia NCT00442897
Effects of Ezetimibe on Postprandial Hyperlipidemia and Endothelial Function Completed Metabolic Syndrome NCT00189085
Vytorin in the Treatment of Alopecia Areata Completed Alopecia Areata NCT01520077
Effects of Epicatechin on Statins for Mitochondrial Dysfunction and Impaired Exercise Capacity Recruiting Statin Intolerance NCT02490527
A Study of LY2623091 in Healthy Participants Completed Healthy Volunteers NCT02300259
Lipid Efficacy Study (0524B-022)(COMPLETED) Completed Primary Hypercholesterolemia|Mixed Hyperlipidemia NCT00269217
Women With Chest Pain and Normal Coronary Arteries Study Terminated Chest Pain NCT00743197
A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808) Completed Hypercholesterolemia NCT00132717
Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels Completed Dyslipidemias NCT00330980
A Multiple Dose Study of PF-04950615 (RN316) in Subjects on High Doses of Statins Completed Hypercholesterolemia|Dyslipidemia NCT01342211
A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease Terminated Depression|Coronary Artery Disease (CAD)|Acute Coronary Syndrome (ACS) NCT00208117
Assessment of the Lipid Lowering Effect of Rosuvastatin Compared to Atorvastatin in Subjects With Coronary Heart Disease Completed Coronary Heart Disease NCT00235950
Survival Benefits of Statins in Breast Cancer Patients Recruiting Breast Cancer Female NCT03971019
Effect of Aminobiphosphonates and Statins on Circulating Vgamma9Vdelta2-T Cells Completed Bone Metastases of a Malignant Tumor NCT01179464
The Effect of Efavirenz and Nelfinavir on the Blood Levels of Certain Lipid-Lowering Drugs Completed HIV Infections|HIV Seronegativity|Lipodystrophy NCT00017758
Stop Atherosclerosis in Native Diabetics Study (SANDS) Completed Atherosclerosis|Cardiovascular Diseases|Heart Diseases|Diabetes Mellitus|Hypertension NCT00047424
Evaluation of Chylomicrons Metabolism in Sub-Clinical Atherosclerosis in Patients Whit Heterozigous Familial Hypercholesterolemia (FH) Treated With Statin Plus Ezetimibe Unknown status Heterozigous Familial Hypercholesterolemia NCT00475826
Single Pill to Avert Cardiovascular Events Unknown status Cardiovascular Disease NCT01313702
Quality of Life in Patients With Statin-Associated Myopathy Terminated Statin Adverse Reaction NCT00850460
HCV Treatment With Fluvastatin, Simvastatin to Improve Interferon Sensitivity Terminated Chronic Hepatitis C NCT01377909
A Study to Evaluate LY3202328 in Overweight Healthy Participants and Dyslipidemia Completed Dyslipidemias NCT02714569
Low-dose Statins and Nutraceuticals in High-intensity Statin-intolerant Patients Unknown status Coronary Artery Disease NCT02001883
Effect of Statins on the Radial Intima-media Thickness After Transradial Angioplasty Unknown status Coronary Artery Disease NCT00952770
Effect of Lipid Lowering Agents on Diabetic Retinopathy and Cardiovascular Risk of Diabetic Patients Not yet recruiting Diabetic Retinopathy NCT04140201
Role of Statin on the Gastric Inflammation in Patients at High Risk of Gastric Cancer Completed Early Gastric Cancer or Gastric Adenoma NCT01813994
The Hypotensive Effect of Metformin in Hypertensive Patients. Unknown status Hypertension NCT02072382
Genetic Influence on Statin Pharmacokinetics Recruiting Hyperlipidemia|Hypercholesterolemia|Dyslipidemia NCT01569867
Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy Completed Necrotic Pulp|Postoperative Pain NCT03084601
Genetic Influence on Statin Pharmacodynamics Withdrawn Hyperlipidemia|Hypercholesterolemia|Dyslipidemia NCT01569854
A Study to Evaluate Ezetimibe in Korean Patients With Primary Hypercholesterolemia (0653-042) Completed Hypercholerolemia NCT00157911
Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases. Unknown status Atherosclerosis|Cardiovascular Diseases NCT00734123
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Completed Hyperglycemia NCT00995670
Effect of Combination Therapy With Two Drugs (Colesevelam and Ezetimibe) in Patients With High Cholesterol Completed Hypercholesterolemia NCT00185107
Comparing an Investigational Medication Versus an Approved Medication in Reducing Cholesterol Levels (0653-025) Completed Hypercholesterolemia NCT00092716
Co-administration Study in Patients With Elevated Cholesterol and Coronary Heart Disease (0653-802)(COMPLETED) Completed Hypercholesterolemia|Coronary Disease NCT00092612
Investigational Drug Study in Patients With Elevated Cholesterol and Coronary Heart Disease (0653-801) Completed Hypercholesterolemia|Coronary Disease NCT00092599
Observational Study of Approaches to Lipid-Lowering Therapy in Russian Patients With Coronary Heart Disease <<Treat to Goal>> (Study P05464) Completed Coronary Heart Disease|Hypercholesterolemia NCT00730132
Action to Control Cardiovascular Risk in Diabetes (ACCORD) Completed Atherosclerosis|Cardiovascular Diseases|Hypercholesterolemia|Hypertension|Diabetes Mellitus, Type 2|Diabetes Mellitus|Coronary Disease NCT00000620
A Study of SCH 58235 (Ezetimibe) When Added to Ongoing Therapy With a Statin in Participants With Primary Hypercholesterolemia, Known Coronary Heart Disease, or Multiple Cardiovascular Risk Factors (P02173) Completed Primary Hypercholesterolemia NCT03882905
Statin Recapture Therapy Before Coronary Artery Bypass Grafting Completed Coronary Artery Disease NCT01715714
HDL-Atherosclerosis Treatment Study (HATS) Completed Cardiovascular Diseases|Coronary Disease|Heart Diseases|Myocardial Ischemia NCT00000553
Naturopathic Treatment for the Prevention of Cardiovascular Disease Completed Cardiovascular Disease NCT00718796
Vytorin Reexamination Study (0653A-174) Completed Primary Hypercholesterolemia and Homozygous Familial Hypercholesterolemia (HoFH) NCT01070966
High Potency Statins and Acute Kidney Injury Completed Hypercholesterolemia NCT02518516
High Potency Statins and the Risk of Diabetes Completed Diabetes Mellitus, Type 2|Cardiovascular Disease NCT02518503
Efficacy and Safety of Prescription Omega-3 Fatty Acid Added to Stable Statin Therapy in Patients With Type 2 Diabetes and Hypertriglyceridemia Completed Diabetes Mellitus, Type 2|Hypertriglycemia NCT02305355
Investigating the Lowest Threshold of Vascular Benefits From LDL Cholesterol Lowering in Patients With Stable CV Disease Active, not recruiting Atherosclerosis|Cardiovascular Diseases NCT03355027
Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia Completed Schizophrenia NCT00802100
Gut Microbiomes in Patients With Metabolic Syndrome Recruiting Metabolic Syndrome NCT03489317
Early Rheumatoid Arthritis COR Intervention Recruiting Rheumatoid Arthritis|Cardiovascular Diseases NCT02246257
A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood Completed HIV Infections NCT00000941
Pharmacokinetic Drug Interactions of AEGR-733 on Lipid-lowering Agents Completed Healthy NCT00359281
Ranolazine and Microvascular Angina by PET in the Emergency Department Completed Microvascular Angina NCT02052011
Using Nudges to Implement Comparative Effectiveness Completed Hypercholesterolemia NCT01575171
Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA) Completed Hypercholesterolemia NCT01222182
Statin Neuroprotection and Carotid Endarterectomy: Safety, Feasibility and Outcomes Recruiting Carotid Artery Stenosis|Strokes NCT02850081
Polypill For Prevention of Cardiovascular Disease Completed Cardiovascular Disease NCT00567307
Maintenance of Muscle Mass in Older People: the Negative Impact of Statin Therapy Completed Myopathy NCT01047163
Integrating Pharmacogenetics In Clinical Care Active, not recruiting Cardiovascular Disease NCT02871934
Prediction and Prevention of Asymptomatic Cardiovascular Insult in Type 1 Diabetic Children: Comparative Effectiveness of Cardioprotective Drugs Completed Diabetes Mellitus, Type 1 NCT03660293
Efficacy of Lapaquistat Acetate Alone or Combined With High-Dose Statin Therapy in Subjects With Hypercholesterolemia Terminated Hypercholesterolemia NCT00249899
Multi-cap for Increase Adherence After Acute Myocardial Infarction Terminated Myocardial Infarction NCT02271178
Study of Alirocumab (REGN727/SAR236553) in Patients With heFH (Heterozygous Familial Hypercholesterolemia) Who Are Not Adequately Controlled With Their LMT (Lipid-Modifying Therapy) Completed Heterozygous Familial Hypercholesterolemia NCT01709500
Anti-Inflammatory Effect of Statins in the Human Endotoxin Model Completed Endotoxemia NCT00309374
INdians Followed for INtensive Lipid Lowering Treatment and Its safetY Terminated Hypercholesterolemia NCT00664469
Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms Completed Pain|Weakness|Cramps|Myalgia or Myositis Nos|HMG COA Reductase Inhibitor Adverse Reaction NCT01032993
Efficacy and Safety of Extended Release (ER) Niacin/Laropiprant When Added to Ongoing Lipid-Modifying Therapy in Patients With High Cholesterol or Abnormal Lipid Levels (MK-0524A-133) Terminated Primary Hypercholesterolemia|Mixed Dyslipidemia NCT01274559
Retrospective Evaluation of the Percentage of Subjects Who Have Reached Their LDL-C Objectives After Treatment With INEGY (Study P05103)(COMPLETED) Completed Primary Hypercholesterolemia NCT00724477
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis Recruiting Non-alcoholic Steatohepatitis NCT01617772
A Study of LY3502970 in Healthy Participants Recruiting Healthy NCT03929744
Fluvastatin in Adults With Dislipidemia With History of Muscle Problems Completed Dyslipidemia NCT00125125
Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study) Completed Diabetic Retinopathy NCT00542178
Efficacy and Safety of Colesevelam in Pediatric Patients With Genetic High Cholesterol Completed Hypercholesterolemia NCT00145574
LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2 Completed Hyperlipidemia NCT01763866
Ekvasis of Atorvastatin (Antorcin®) Treatment in Patients With Acute Cardiovascular Events Completed Cardiovascular Disorders NCT01770210
High-Density Lipoprotein (HDL) Cholesterol Increased Plaque Stabilization in the Elderly Completed Atherosclerosis|Cardiovascular Disease NCT00127218
To Explore the Treatment Effect of Various Commercially Available Statins on Patients With Hyperlipidemia Completed Hyperlipidemias NCT00726362
Ezetimibe in Patients Hypo-responsive to Statins Terminated High Cholesterol|Coronary Artery Disease NCT00965055
Evaluation of Patients Treated With HMG-CoA Reductase Inhibitors to Reach Cholesterol Target Values Completed Hypercholesterolaemia NCT01483950
Non-interventional Study (NIS) to Assess Reaching of Cholesterol Target Values in Patients Treated With HMG-CoA Reductase Inhibitors Completed Hypercholesterolaemia NCT01257971
Evaluation of the Efficacy of Rosuvastatin in Daily Practice (TARGET) Completed Hypercholesterolemia|Coronary Heart Disease NCT00396110
PharmacOdynamic compaRison of piTavastatin Versus atOrvastatin on Platelet Reactivity Unknown status Coronary Artery Disease NCT01648829
Pharmacodynamic Effects of Atorvastatin vs. Rosuvastatin on Platelet Reactivity Unknown status Coronary Artery Disease NCT01567774
The Triglyceride Lowering Effect of an Omega-3 Fat (DHA) in Addition to Statin Therapy for Patients With CAD or Diabetes Completed Hypertriglyceridemia (TG>200<500)|Hyperlipidemia|Coronary Artery Disease|Coronary Risk Equivalent|Diabetes NCT00360217
Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression of Peripheral Arterial Disease (The ELIMIT Study) Completed Peripheral Arterial Disease NCT00687076
The Efficacy and Safety of ITF2357 in AIS Unknown status Autoinflammatory Syndromes|HIDS|TRAPS|Schnitzler's Syndrome NCT00442182
Statins at the Primary Care Level Completed Dyslipidemia NCT02380911
Efficacy and Safety of PRC-4016 in Subjects With Mixed Dyslipidemia Terminated Dyslipidemia NCT01972178
Erythrocyte-bound Apolipoprotein B After Withdrawal of Statin Therapy Completed Hyperlipidemia|Atherosclerosis NCT01634906
Evaluation of Ubiquinol on Mitochondrial Oxidative Capacity in Statin Patients Using 31PMRS Completed Myopathy|HMG COA Reductase Inhibitor Adverse Reaction|Hypercholesterolemia NCT01702987
Effect of Succinylcholine on Patients Using Statins Completed Pain NCT00986583
The International Polycap Study 3 (TIPS-3) Active, not recruiting Cardiovascular Disease|Fractures|Cancers NCT01646437
DLBS1033 for Acute Ischemic Stroke Patients Recruiting Acute Ischemic Stroke|Partial Anterior Circulation Infarct|Lacunar Anterior Circulation Infarct NCT02133521
Observational Study On Compliance Of Statin Treatment Of Patients With High Blood Cholesterol Levels Completed Dyslipidemia NCT00673660
DLBS1033 for the Treatment of Acute Ischemic Stroke Terminated Acute Ischemic Stroke NCT02362984
Efficacy of Lapaquistat Acetate in Subjects Currently Treated With Lipid-Lowering Therapy. Completed Type 2 Diabetes NCT00251680
Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia Recruiting Vaso-occlusive Crisis|Sickle Cell Disease|Sickle Cell Anemia in Children NCT04301336
Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis Completed Stroke|Transient Ischemic Attack|Atherosclerosis|Stenosis|Stents NCT00691314
Stenting Versus Best Medical Treatment of Asymptomatic High Grade Carotid Artery Stenosis Completed Asymptomatic|Artery NCT00497094
Microvascular Disease Exercise Trial Active, not recruiting Coronary Microvascular Disease NCT02045459
Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors Suspended Parkinson Disease|Dyskinesia, Drug-Induced NCT04064294
The Effect of Sarpogrelate and High Dose Statin on the Reduction of Coronary Spasm Unknown status Variant Angina NCT01674686
Open Label Study of Long Term Safety Evaluation of Alirocumab Completed Hypercholesterolemia NCT01954394
Anti Ischemic Effects of Abciximab in Angioplasty and Stenting Patients Completed Coronary Artery Disease NCT00379418
Comparative Efficacy Evaluation of Lipids When Treated With Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL Completed Dyslipidemia|Coronary Heart Disease|Atherosclerosis|Stroke|Diabetes NCT00079638
LIFESTAT - Living With Statins, a Cross Sectional Study Completed Cardiovascular Disease|Diabetes Mellitus NCT02250677
A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients Recruiting Prostate Cancer|Cardiovascular Disease NCT03127631
Evaluation of Patients With Statin Myopathy Using an N of 1 Trial Design Completed Statin Myopathy NCT01259791
Hospital- and Home-based Supervised Exercise Versus UNsupervised Walk Advice For Patients With InTermittent Claudication Active, not recruiting Intermittent Claudication NCT02341716
Clinical Study to Evaluate Adherence Improvement Fixed-dose Combination of Olostar Tab. in Patients With Hypertension and Dyslipidemia Completed Hypertension|Dyslipidemias NCT04061824
Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE) Completed Hypercholesterolemia NCT02476006
Vascular and Metabolic Effects of Vytorin Completed Hypercholesterolemia NCT01660945
Nephropathy In Type 2 Diabetes and Cardio-renal Events Unknown status Diabetic Nephropathy NCT00535925
Influence of Statins in Artery Aneurysms Unknown status Statin|Aneurysm|Extracellular Matrix Alteration NCT03061487
UMPIRE - Use of a Multidrug Pill In Reducing Cardiovascular Events Completed Cardiovascular Diseases NCT01057537
A Prospective Trial to Assess Cost and Clinical Outcomes of a Clinical Pharmacogenomic Program Active, not recruiting Adverse Drug Reaction NCT02297126
Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial Completed Cardiovascular Disease NCT01326676
Evaluation of Alirocumab Versus Ezetimibe on Top of Statin in Asia in High Cardiovascular Risk Patients With Hypercholesterolemia Completed Hypercholesterolemia NCT02715726
The Indian POLYCAP Study (TIPS) Completed Cardiovascular Diseases NCT00443794
Study to Evaluate the Efficacy and Safety of an Every Four Weeks Treatment Regimen of Alirocumab (REGN727/ SAR236553) in Patients With Primary Hypercholesterolemia (ODYSSEY CHOICE 1) Completed Hypercholesterolemia NCT01926782
Evaluation of Alirocumab in Addition to Lipid-Modifying Therapy in Patients With High Cardiovascular Risk and Hypercholesterolemia in South Korea and Taiwan Completed Hypercholesterolemia NCT02289963
Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With High Cardiovascular Risk and Hypercholesterolemia (ODYSSEY COMBO I) Completed Hypercholesterolemia NCT01644175
Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia Not Adequately Controlled With Their Lipid-Modifying Therapy Completed Hypercholesterolemia NCT01623115
Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia (ODYSSEY HIGH FH) Completed Hypercholesterolaemia NCT01617655
Long-term Safety and Tolerability of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY Long Term) Completed Hypercholesterolemia NCT01507831
Efficacy and Safety Evaluation of Alirocumab in Patients With Heterozygous Familial Hypercholesterolemia or High Cardiovascular Risk Patients With Hypercholesterolemia on Lipid Modifying Therapy (ODYSSEY JAPAN) Completed Hypercholesterolemia NCT02107898
Evaluation of ETC-1002 vs Placebo in Patients Receiving Ongoing Statin Therapy Completed Hypercholesterolemia NCT02072161
Integrated Primary Care for Diabetes and Cardiovascular Disease Unknown status Diabetes Mellitus|Hypertension|Heart Failure|Ischemic Heart Disease|Cerebrovascular Disease NCT02795910
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia Recruiting Hypercholesterolaemia NCT03510884
An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia Completed Hypercholesterolemia NCT03510715
Intensive Statin Treatment in Chinese Coronary Artery Disease Patients Undergoing PCI Completed Non-ST Segment Elevation Myocardial Infarction|Unstable Angina Pectoris|Stable Angina Pectoris NCT01293097
A Study to Design a Model Cohort for Analysis of Dyslipidemia (MK-0653A-204) Completed Dyslipidemia|Hypercholesterolemia NCT01414192
Glucagon-like Peptide (GLP) Utilization and Safety Completed Diabetes Mellitus, Type 2 NCT01767389
Efficacy of Lapaquistat Acetate Co-Administered With Statins in Subjects With Hypercholesterolemia Terminated Hypercholesterolemia NCT00532311
Estimation of the Long Term Effectiveness of Routine Use of Cardiac Shock Wave Therapy Withdrawn Coronary Heart Disease (CHD) NCT01631409
A Study of LY3015014 in Participants With High Cholesterol Completed Hypercholesterolemia NCT01890967
A Study of AMR101 to Evaluate Its Ability to Reduce Cardiovascular Events in High Risk Patients With Hypertriglyceridemia and on Statin. The Primary Objective is to Evaluate the Effect of 4 g/Day AMR101 for Preventing the Occurrence of a First Major Cardiovascular Event. Completed Cardiovascular Diseases NCT01492361
Efficacy and Safety of AMR101 (Ethyl Icosapentate) in Patients With Fasting Triglyceride (Tg) Levels ≥ 500 and ≤ 2000 mg/dL Completed Hypertriglyceridemia NCT01047683
Effect of AMR101 (Ethyl Icosapentate) on Triglyceride (Tg) Levels in Patients on Statins With High Tg Levels (≥ 200 and < 500 mg/dL) Completed Hypertriglyceridemia NCT01047501
Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation Completed Inflammation Plaque, Atherosclerotic|Coronary Disease|Renin-Angiotensin System NCT02378064
Optimal Blood Pressure and Cholesterol Targets for Preventing Recurrent Stroke in Hypertensives Recruiting Stroke|Transient Ischemic Attack|Hypertension NCT01563731
Diabetic Treatment Adherence Completed Endocrine System Diseases NCT01318564
Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Ezetimibe on Top of Statin in High Cardiovascular Risk Patients With Hypercholesterolemia (ODYSSEY COMBO II) Completed Hypercholesterolemia NCT01644188
Belatacept Evaluation of Nephroprotection and Efficacy as First-line Immunosuppression (BENEFIT) Completed Kidney Transplantation|Chronic Kidney Failure NCT00256750
Socioeconomic Status, Secondary Prevention Activities and Recurrence After a Myocardial Infarction Completed Socioeconomic Status|Secondary Prevention|Myocardial Infarction|Cardiovascular Disease|Stroke NCT04199663

References

Publication DOI Pubmed PMCID
Simvastatin impairs growth hormone-activated signal transducer and activator of transcription (STAT) signaling pathway in UMR-106 osteosarcoma cells. PloS one María Claudia Sandoval-Usme, Adriana Umaña-Pérez, Borja Guerra, Octavio Hernández-Perera, Orlando Hernández-Perera, José Manuel García-Castellano, Leandro Fernández-Pérez, Myriam Sánchez-Gómez, 9, 1, None, 2014-01-29, 10.1371/journal.pone.0087769 10.1371/journal.pone.0087769 24489959 PMC3906206

Vendors

Company Lnk to product
Tocris https://www.tocris.com/products/simvastatin_1965
Caymanchemicals https://www.caymanchem.com/product/10010344/simvastatin
MedChemExpress https://www.medchemexpress.com/Simvastatin.html
Selleckchem https://www.selleckchem.com/products/Simvastatin(Zocor).html
Biovision https://www.biovision.com/simvastatin.html
Santa Cruz Biotechnology https://www.scbt.com/p/simvastatin-79902-63-9
APExBIO https://www.apexbt.com/simvastatin-zocor.html

Filter data

Compound Simvastatin
Experiment types Bromodeoxyuridine (BrdU) incorporation assay, Invasion assay , MTT Assay , Migration assay , RT-qPCR, Western Blot, Wound healing assay
Concentrations 0.10, 0.30, 0.50, 1.00, 10.00, 2.00, 20.00, 3.00, 30.00, 5.00, 7.00
Cell lines BRL-4, MCF-7, UMR-106
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT3, STAT5, p-STAT1(Y701), p-STAT3(Y705), p-STAT5(S726/731), p-STAT5(Y694)
Other CIS, JAK2, SOCS-3, p-JAK2(Y1007/1008), β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Simvastatin Bromodeoxyuridine (BrdU) incorporation assay Influence on cell proliferation 0.10 µM UMR-106 Homo sapiens
Simvastatin Bromodeoxyuridine (BrdU) incorporation assay Influence on cell proliferation 1.00 µM UMR-106 Homo sapiens
Simvastatin Bromodeoxyuridine (BrdU) incorporation assay Influence on cell proliferation 10.00 µM UMR-106 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 0.10 µM BRL-4 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 0.30 µM BRL-4 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 1.00 µM BRL-4 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 3.00 µM BRL-4 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 10.00 µM BRL-4 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 30.00 µM BRL-4 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 0.10 µM MCF-7 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 0.30 µM MCF-7 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 1.00 µM MCF-7 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 3.00 µM MCF-7 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 10.00 µM MCF-7 Homo sapiens
Simvastatin MTT Assay Influence on cell proliferation 30.00 µM MCF-7 Homo sapiens
Simvastatin Wound healing assay Influence on cell motility 1.00 µM UMR-106 Homo sapiens
Simvastatin Wound healing assay Influence on cell motility 3.00 µM UMR-106 Homo sapiens
Simvastatin Wound healing assay Influence on cell motility 10.00 µM UMR-106 Homo sapiens
Simvastatin Migration assay Influence on cell motility 0.50 µM UMR-106 Homo sapiens
Simvastatin Migration assay Influence on cell motility 1.00 µM UMR-106 Homo sapiens
Simvastatin Migration assay Influence on cell motility 3.00 µM UMR-106 Homo sapiens
Simvastatin Migration assay Influence on cell motility 5.00 µM UMR-106 Homo sapiens
Simvastatin Migration assay Influence on cell motility 10.00 µM UMR-106 Homo sapiens
Simvastatin Invasion assay Influence on cell motility 0.50 µM UMR-106 Homo sapiens
Simvastatin Invasion assay Influence on cell motility 1.00 µM UMR-106 Homo sapiens
Simvastatin Invasion assay Influence on cell motility 3.00 µM UMR-106 Homo sapiens
Simvastatin Invasion assay Influence on cell motility 5.00 µM UMR-106 Homo sapiens
Simvastatin Invasion assay Influence on cell motility 10.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens p-STAT5(Y694)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens p-STAT5(Y694)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens p-STAT5(Y694)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens STAT5
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens STAT5
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens STAT5
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens p-STAT3(Y705)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens p-STAT3(Y705)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens p-STAT3(Y705)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens STAT3
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens STAT3
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens STAT3
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens p-STAT1(Y701)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens p-STAT1(Y701)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens p-STAT1(Y701)
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens STAT1
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens STAT1
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens STAT1
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 1.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 3.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (2h) in presence of GH 5.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 1.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 3.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 5.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 7.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 10.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 1.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 3.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 5.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 7.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 10.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 1.00 µM UMR-106 Homo sapiens p-STAT5(Y694)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 3.00 µM UMR-106 Homo sapiens p-STAT5(Y694)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 5.00 µM UMR-106 Homo sapiens p-STAT5(Y694)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 7.00 µM UMR-106 Homo sapiens p-STAT5(Y694)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 10.00 µM UMR-106 Homo sapiens p-STAT5(Y694)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 1.00 µM UMR-106 Homo sapiens p-STAT5(S726/731)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 3.00 µM UMR-106 Homo sapiens p-STAT5(S726/731)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 5.00 µM UMR-106 Homo sapiens p-STAT5(S726/731)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 7.00 µM UMR-106 Homo sapiens p-STAT5(S726/731)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 10.00 µM UMR-106 Homo sapiens p-STAT5(S726/731)
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 1.00 µM UMR-106 Homo sapiens STAT5
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 3.00 µM UMR-106 Homo sapiens STAT5
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 5.00 µM UMR-106 Homo sapiens STAT5
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 7.00 µM UMR-106 Homo sapiens STAT5
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 10.00 µM UMR-106 Homo sapiens STAT5
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 1.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 3.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 5.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 7.00 µM UMR-106 Homo sapiens
Simvastatin Western Blot Influence on protein activity (10h) in presence of GH 10.00 µM UMR-106 Homo sapiens
Simvastatin RT-qPCR Influence on transcriptional activity in presence of GH 2.00 µM UMR-106 Homo sapiens
Simvastatin RT-qPCR Influence on transcriptional activity in presence of GH 10.00 µM UMR-106 Homo sapiens
Simvastatin RT-qPCR Influence on transcriptional activity in presence of GH 20.00 µM UMR-106 Homo sapiens
Simvastatin RT-qPCR Influence on transcriptional activity in presence of GH 2.00 µM UMR-106 Homo sapiens
Simvastatin RT-qPCR Influence on transcriptional activity in presence of GH 10.00 µM UMR-106 Homo sapiens
Simvastatin RT-qPCR Influence on transcriptional activity in presence of GH 20.00 µM UMR-106 Homo sapiens