| Withacnistin |
Influence on tumor growth |
Tumor volume |
20.00 mg/kg |
MDA-MB-468(xenograft) |
Mus musculus |
ErbB2 |
|
|
| YM-341619 |
Influence on cytokine production |
ELISA |
0.01 µM |
Spleen T cells |
Mus musculus |
c57BL/6 |
|
|
| YM-341619 |
Influence on cytokine production |
ELISA |
0.10 µM |
Spleen T cells |
Mus musculus |
c57BL/6 |
|
|
| YM-341619 |
Influence on cytokine production |
ELISA |
1.00 µM |
Spleen T cells |
Mus musculus |
c57BL/6 |
|
|
| YM-341619 |
Influence on cytokine production |
ELISA |
10.00 µM |
Spleen T cells |
Mus musculus |
c57BL/6 |
|
|
| YM-341619 |
Influence on cytokine production |
ELISA |
0.01 µM |
Spleen T cells |
Mus musculus |
c57BL/6 |
|
|
| YM-341619 |
Influence on cytokine production |
ELISA |
0.10 µM |
Spleen T cells |
Mus musculus |
c57BL/6 |
|
|
| YM-341619 |
Influence on cytokine production |
ELISA |
1.00 µM |
Spleen T cells |
Mus musculus |
c57BL/6 |
|
|
| YM-341619 |
Influence on cytokine production |
ELISA |
10.00 µM |
Spleen T cells |
Mus musculus |
c57BL/6 |
|
|
| Galiellalactone |
Influence on cell proliferation |
WST-1 |
N/A µM |
DU145 |
Homo sapiens |
|
|
|
| Galiellalactone |
Influence on protein activity |
Western Blot |
10.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on protein activity |
Western Blot |
25.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on protein activity |
Western Blot |
50.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on protein activity |
Western Blot |
100.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on DNA-protein binding |
EMSA |
5.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on DNA-protein binding |
EMSA |
10.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on DNA-protein binding |
EMSA |
25.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on protein activity |
Western Blot |
5.00 µM |
DU145 |
Homo sapiens |
|
p-STAT3(Y705) |
|
| Galiellalactone |
Influence on protein activity |
Western Blot |
5.00 µM |
DU145 |
Homo sapiens |
|
p-STAT3(Y727) |
|
| Galiellalactone |
Influence on protein activity |
Western Blot |
5.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on protein activity In presence IL-6 |
Western Blot |
25.00 µM |
LNCaP |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on protein activity In presence IL-6 |
Western Blot |
25.00 µM |
LNCaP |
Homo sapiens |
|
p-STAT3 |
|
| Galiellalactone |
Influence on protein activity In presence IL-6 |
Luciferse activity |
5.00 µM |
LNCaP |
Homo sapiens |
|
STAT3 |
|
| Galiellalactone |
Influence on protein activity In presence IL-6 |
Luciferse activity |
10.00 µM |
LNCaP |
Homo sapiens |
|
STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
50.00 µM |
HMEC |
Homo sapiens |
|
p-STAT1 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
p-STAT1 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
10.00 µM |
HMEC |
Homo sapiens |
|
p-STAT1 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
5.00 µM |
HMEC |
Homo sapiens |
|
p-STAT1 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
50.00 µM |
HMEC |
Homo sapiens |
|
STAT1 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
STAT1 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
10.00 µM |
HMEC |
Homo sapiens |
|
STAT1 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
5.00 µM |
HMEC |
Homo sapiens |
|
STAT1 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
50.00 µM |
HMEC |
Homo sapiens |
|
p-STAT2 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
p-STAT2 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
10.00 µM |
HMEC |
Homo sapiens |
|
p-STAT2 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
5.00 µM |
HMEC |
Homo sapiens |
|
p-STAT2 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
50.00 µM |
HMEC |
Homo sapiens |
|
STAT2 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
STAT2 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
10.00 µM |
HMEC |
Homo sapiens |
|
STAT2 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
5.00 µM |
HMEC |
Homo sapiens |
|
STAT2 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
50.00 µM |
HMEC |
Homo sapiens |
|
p-STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
p-STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
10.00 µM |
HMEC |
Homo sapiens |
|
p-STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
5.00 µM |
HMEC |
Homo sapiens |
|
p-STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
50.00 µM |
HMEC |
Homo sapiens |
|
STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
10.00 µM |
HMEC |
Homo sapiens |
|
STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
5.00 µM |
HMEC |
Homo sapiens |
|
STAT3 |
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
50.00 µM |
HMEC |
Homo sapiens |
|
|
|
| C01L_F03 |
Influence on protein activity in presence of IFNα |
Western Blot |
25.00 µM |
HMEC |
Homo sapiens |
|
|
|
