C01L_F03

Name Value
Weight 419.437 g/mol
Zinc ID ZINC5312694
Smiles Cc1noc(C)c1COc1ccc(C(=O)O[C@@H](C)C(=O)Nc2cccc(C#N)c2)cc1
Molecular formula C23H21N3O5
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS N/A

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs. Frontiers in immunology Martyna Plens-Galaska, Malgorzata Szelag, Aida Collado, Patrice Marques, Susana Vallejo, Mariella Ramos-González, Joanna Wesoly, María Jesus Sanz, Concepción Peiró, Hans A R Bluyssen, 9, None, None, 2018-09-19, 10.3389/fimmu.2018.02141 10.3389/fimmu.2018.02141 30283459 PMC6156247

Filter data

Compound C01L_F03
Experiment types ChIP-qPCR, Leukocyte adhesion assay , RT-qPCR, Western Blot, Wound healing assay
Concentrations 10.00, 25.00, 5.00, 50.00
Cell lines HMEC
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT1:IRF1, STAT1:OAS2, STAT2, STAT2:OAS2, STAT3, STAT3:SOCS3, p-STAT1, p-STAT2, p-STAT3
Other CCL5, CXCL10, CXCL9, ICAM1, IFIT2, IRF1, Nf-κB:IER3, Nf-κB:IRF1, OAS2, SOCS3, Tubulin, VCAM1

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 50.00 µM HMEC Homo sapiens p-STAT1
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 25.00 µM HMEC Homo sapiens p-STAT1
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 10.00 µM HMEC Homo sapiens p-STAT1
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 5.00 µM HMEC Homo sapiens p-STAT1
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 50.00 µM HMEC Homo sapiens STAT1
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 25.00 µM HMEC Homo sapiens STAT1
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 10.00 µM HMEC Homo sapiens STAT1
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 5.00 µM HMEC Homo sapiens STAT1
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 50.00 µM HMEC Homo sapiens p-STAT2
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 25.00 µM HMEC Homo sapiens p-STAT2
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 10.00 µM HMEC Homo sapiens p-STAT2
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 5.00 µM HMEC Homo sapiens p-STAT2
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 50.00 µM HMEC Homo sapiens STAT2
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 25.00 µM HMEC Homo sapiens STAT2
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 10.00 µM HMEC Homo sapiens STAT2
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 5.00 µM HMEC Homo sapiens STAT2
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 50.00 µM HMEC Homo sapiens p-STAT3
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 25.00 µM HMEC Homo sapiens p-STAT3
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 10.00 µM HMEC Homo sapiens p-STAT3
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 5.00 µM HMEC Homo sapiens p-STAT3
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 50.00 µM HMEC Homo sapiens STAT3
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 25.00 µM HMEC Homo sapiens STAT3
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 10.00 µM HMEC Homo sapiens STAT3
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 5.00 µM HMEC Homo sapiens STAT3
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 50.00 µM HMEC Homo sapiens
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 25.00 µM HMEC Homo sapiens
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 10.00 µM HMEC Homo sapiens
C01L_F03 Western Blot Influence on protein activity in presence of IFNα 5.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNα 10.00 µM HMEC Homo sapiens
C01L_F03 ChIP-qPCR Influence on protein-DNA interactions 50.00 µM HMEC Homo sapiens STAT1:IRF1
C01L_F03 ChIP-qPCR Influence on protein-DNA interactions 50.00 µM HMEC Homo sapiens STAT3:SOCS3
C01L_F03 ChIP-qPCR Influence on protein-DNA interactions 50.00 µM HMEC Homo sapiens STAT1:OAS2
C01L_F03 ChIP-qPCR Influence on protein-DNA interactions 50.00 µM HMEC Homo sapiens STAT2:OAS2
C01L_F03 ChIP-qPCR Influence on protein-DNA interactions 50.00 µM HMEC Homo sapiens
C01L_F03 ChIP-qPCR Influence on protein-DNA interactions 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 10.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 50.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 25.00 µM HMEC Homo sapiens
C01L_F03 RT-qPCR Infleunce on gene expression in presence of IFNγ and LPS 10.00 µM HMEC Homo sapiens
C01L_F03 Wound healing assay Influence on cell motility 50.00 µM HMEC Homo sapiens
C01L_F03 Leukocyte adhesion assay Influence on cell adhesion 50.00 µM HMEC Homo sapiens