Galiellalactone

Name Value
Weight 194.230 g/mol
Zinc ID ZINC256458627
Smiles C[C@@H]1C=C2C(=O)O[C@@H]3CC[C@@H](C1)[C@]23O
Molecular formula C11H14O3
Mode of inhibition Direct STAT DBD; targetting DBD
CAS 133613-71-5

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. The Journal of biological chemistry Nicholas Don-Doncow, Zilma Escobar, Martin Johansson, Sven Kjellström, Victor Garcia, Eduardo Munoz, Olov Sterner, Anders Bjartell, Rebecka Hellsten, 289, 23, 2014-06-06, 2014-04-22, 10.1074/jbc.M114.564252 10.1074/jbc.M114.564252 24755219 PMC4047371

Vendors

Company Lnk to product
Tocris https://www.tocris.com/products/galiellalactone_6218
Santa Cruz Biotechnology https://www.scbt.com/p/galiellalactone-133613-71-5
Caymanchemical https://www.caymanchem.com/product/15387/galiellalactone
Molbase http://www.molbase.com/en/cas-133613-71-5.html
Abmole http://www.abmole.com/products/galiellalactone.html
Glixx Laboratories http://glixxlabs.com/chemical-products/bioactive-screen-leads-p6/GLXC-11505
Chemexpress https://www.chemexpress.cn/133613-71-5.htm
BioVision https://www.biovision.com/galiellactone.html

Filter data

Compound Galiellalactone
Experiment types EMSA, Luciferse activity, WST-1, Western Blot
Concentrations 10.00, 100.00, 25.00, 5.00, 50.00, N/A
Cell lines DU145, LNCaP
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3, p-STAT3(Y705), p-STAT3(Y727)
Other

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Galiellalactone WST-1 Influence on cell proliferation N/A µM DU145 Homo sapiens
Galiellalactone Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens STAT3
Galiellalactone Western Blot Influence on protein activity 25.00 µM DU145 Homo sapiens STAT3
Galiellalactone Western Blot Influence on protein activity 50.00 µM DU145 Homo sapiens STAT3
Galiellalactone Western Blot Influence on protein activity 100.00 µM DU145 Homo sapiens STAT3
Galiellalactone EMSA Influence on DNA-protein binding 5.00 µM DU145 Homo sapiens STAT3
Galiellalactone EMSA Influence on DNA-protein binding 10.00 µM DU145 Homo sapiens STAT3
Galiellalactone EMSA Influence on DNA-protein binding 25.00 µM DU145 Homo sapiens STAT3
Galiellalactone Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens p-STAT3(Y705)
Galiellalactone Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens p-STAT3(Y727)
Galiellalactone Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens STAT3
Galiellalactone Western Blot Influence on protein activity In presence IL-6 25.00 µM LNCaP Homo sapiens STAT3
Galiellalactone Western Blot Influence on protein activity In presence IL-6 25.00 µM LNCaP Homo sapiens p-STAT3
Galiellalactone Luciferse activity Influence on protein activity In presence IL-6 5.00 µM LNCaP Homo sapiens STAT3
Galiellalactone Luciferse activity Influence on protein activity In presence IL-6 10.00 µM LNCaP Homo sapiens STAT3