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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
Cyclometalated rhodium(III) complex 12 Influence on protein binding Cell-free assay 30.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein binding in presence of EGF Fluorescence polarization assay 0.30 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein binding in presence of EGF Fluorescence polarization assay 1.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein binding in presence of EGF Fluorescence polarization assay 3.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein binding in presence of EGF Fluorescence polarization assay 10.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein binding in presence of EGF Fluorescence polarization assay 30.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 3.00 µM A375 Homo sapiens p-STAT3 (Y705)
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 10.00 µM A375 Homo sapiens p-STAT3 (Y705)
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 20.00 µM A375 Homo sapiens p-STAT3 (Y705)
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 3.00 µM A375 Homo sapiens STAT3
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 10.00 µM A375 Homo sapiens STAT3
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 20.00 µM A375 Homo sapiens STAT3
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 3.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 10.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein activity Western Blot 20.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Influence on protein activity Immunohistochemistry 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Influence on protein activity Immunohistochemistry 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Influence on protein activity Immunohistochemistry 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Influence on blood flow Laser Doppler flowmetry 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Dasatinib Influence on gene expression qRT-PCR 3.30 nM K562 Homo sapiens STAT5A
Dasatinib Influence on gene expression qRT-PCR 3.30 nM K562 Homo sapiens STAT5B
Dasatinib Influence on protein activity Western Blot 3.30 nM K562 Homo sapiens STAT5A
Dasatinib Influence on protein activity Western Blot 3.30 nM K562 Homo sapiens STAT5B
Dasatinib Influence on protein activity Western Blot 3.30 nM K562 Homo sapiens
Dasatinib Influence on cell viability Colony formation assay 10.00 nM MPN Homo sapiens
Dasatinib Influence on cell viability Colony formation assay 1.00 nM ET Homo sapiens
Dasatinib Influence on protein activity Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 100.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity in presence of Ruxololitinib Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 100.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity in presence of Ruxololitinib Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 100.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity in presence of Ruxololitinib Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 100.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity in presence of Ruxololitinib Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 100.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity in presence of Ruxololitinib Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens p-STAT5
Dasatinib Influence on protein activity Western Blot 100.00 nM BaF3 JAK2 V617F Homo sapiens p-STAT5
Dasatinib Influence on protein activity in presence of Ruxololitinib Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens p-STAT5
Dasatinib Influence on protein activity Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens STAT5
Dasatinib Influence on protein activity Western Blot 100.00 nM BaF3 JAK2 V617F Homo sapiens STAT5
Dasatinib Influence on protein activity in presence of Ruxololitinib Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens STAT5
Dasatinib Influence on protein activity Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity Western Blot 100.00 nM BaF3 JAK2 V617F Homo sapiens
Dasatinib Influence on protein activity in presence of Ruxololitinib Western Blot 10.00 nM BaF3 JAK2 V617F Homo sapiens