Cyclometalated rhodium(III) complex 12

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Antagonizing STAT3 Dimerization with a Rhodium(III) Complex 10.1002/anie.201404686 https://pubmed.ncbi.nlm.nih.gov/24889897/ N/A

Filter data

Compound Cyclometalated rhodium(III) complex 12
Experiment types Average body weight, Average tumor volume, Cell-free assay, Fluorescence polarization assay, Immunohistochemistry, Laser Doppler flowmetry, Mean organ weight, Mean tumor weight, Western Blot
Concentrations 0.30, 1.00, 10.00, 20.00, 3.00, 30.00, 75.00
Cell lines A375, A375(xenograft)
Organisms Homo sapiens, Mus musculus
Animal models BALB/c
STAT proteins STAT3, p-STAT3 (Y705)
Other Cox-2, GAPDH, Pro-caspase 3, iNOS

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Cyclometalated rhodium(III) complex 12 Average tumor volume Influence on tumor growth 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Average body weight Influence on tumor growth 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Mean tumor weight Influence on tumor growth 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Mean organ weight Influence on tumor growth 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Cell-free assay Influence on protein binding 0.30 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Cell-free assay Influence on protein binding 1.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Cell-free assay Influence on protein binding 3.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Cell-free assay Influence on protein binding 10.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Cell-free assay Influence on protein binding 30.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Fluorescence polarization assay Influence on protein binding in presence of EGF 0.30 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Fluorescence polarization assay Influence on protein binding in presence of EGF 1.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Fluorescence polarization assay Influence on protein binding in presence of EGF 3.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Fluorescence polarization assay Influence on protein binding in presence of EGF 10.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Fluorescence polarization assay Influence on protein binding in presence of EGF 30.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 3.00 µM A375 Homo sapiens p-STAT3 (Y705)
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 10.00 µM A375 Homo sapiens p-STAT3 (Y705)
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 20.00 µM A375 Homo sapiens p-STAT3 (Y705)
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 3.00 µM A375 Homo sapiens STAT3
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 10.00 µM A375 Homo sapiens STAT3
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 20.00 µM A375 Homo sapiens STAT3
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 3.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 10.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Western Blot Influence on protein activity 20.00 µM A375 Homo sapiens
Cyclometalated rhodium(III) complex 12 Immunohistochemistry Influence on protein activity 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Immunohistochemistry Influence on protein activity 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Immunohistochemistry Influence on protein activity 75.00 mg/kg A375(xenograft) Mus musculus BALB/c
Cyclometalated rhodium(III) complex 12 Laser Doppler flowmetry Influence on blood flow 75.00 mg/kg A375(xenograft) Mus musculus BALB/c