| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 (S727) |
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
10.00 µM |
U266 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
MM1.RL |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
MM1.RL |
Homo sapiens |
|
STAT3 |
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
MM1.RL |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
U266 |
Homo sapiens |
|
p-STAT3 (Y705) |
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
U266 |
Homo sapiens |
|
STAT3 |
|
| Withaferin A |
Influence on protein activity in presence of IL-6 |
Western Blot |
5.00 µM |
U266 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on cell viability |
MTT |
N/A µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on cell proliferation |
MTT |
1.00 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on cells motility |
Wound healing assay |
0.00 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on cells motility |
Wound healing assay |
0.01 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on cells motility |
Wound healing assay |
0.10 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on cells motility |
Wound healing assay |
1.00 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on cells motility |
Transwell migration assay |
1.00 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on protein transcriptional activity in presence of IL-6 |
Transcriptional activity assay |
0.06 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on protein transcriptional activity in presence of IL-6 |
Transcriptional activity assay |
0.12 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on protein transcriptional activity in presence of IL-6 |
Transcriptional activity assay |
0.25 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on protein transcriptional activity in presence of IL-6 |
Transcriptional activity assay |
0.50 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on protein transcriptional activity in presence of IL-6 |
Transcriptional activity assay |
1.00 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on protein transcriptional activity in presence of IL-6 |
Immunofluorescence |
1.00 µM |
HCT116 |
Homo sapiens |
|
STAT3 |
|
| Withaferin A |
Influence on protein transcriptional activity in presence of IL-6 |
Immunofluorescence |
1.00 µM |
HCT116 |
Homo sapiens |
|
|
|
| Withaferin A |
Influence on tumor growth |
Tumor weight |
2.00 mg/kg |
HCT116 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Withaferin A |
Influence on tumor growth |
Tumor volume |
2.00 mg/kg |
HCT116 (xenograft) |
Mus musculus |
BALB/c |
|
|
| Withaferin A |
Influence on tumor growth |
Body weight |
2.00 mg/kg |
HCT116 (xenograft) |
Mus musculus |
BALB/c |
|
|
| WP1066 |
Influence on protein activity |
Western Blot |
2.50 µM |
Caki-1 |
Homo sapiens |
|
p-STAT3 |
|
| WP1066 |
Influence on protein activity |
Western Blot |
5.00 µM |
Caki-1 |
Homo sapiens |
|
p-STAT3 |
|
| WP1066 |
Influence on protein activity |
Western Blot |
2.50 µM |
786-O |
Homo sapiens |
|
p-STAT3 |
|
| WP1066 |
Influence on protein activity |
Western Blot |
5.00 µM |
786-O |
Homo sapiens |
|
p-STAT3 |
|
| WP1066 |
Influence on protein activity |
Western Blot |
2.50 µM |
Caki-1 |
Homo sapiens |
|
STAT3 |
|
| WP1066 |
Influence on protein activity |
Western Blot |
5.00 µM |
Caki-1 |
Homo sapiens |
|
STAT3 |
|
| WP1066 |
Influence on protein activity |
Western Blot |
2.50 µM |
786-O |
Homo sapiens |
|
STAT3 |
|
| WP1066 |
Influence on protein activity |
Western Blot |
5.00 µM |
786-O |
Homo sapiens |
|
STAT3 |
|
| WP1066 |
Influence on protein activity |
Western Blot |
2.50 µM |
Caki-1 |
Homo sapiens |
|
|
|
| WP1066 |
Influence on protein activity |
Western Blot |
5.00 µM |
Caki-1 |
Homo sapiens |
|
|
|
| WP1066 |
Influence on protein activity |
Western Blot |
2.50 µM |
786-O |
Homo sapiens |
|
|
|
| WP1066 |
Influence on protein activity |
Western Blot |
5.00 µM |
786-O |
Homo sapiens |
|
|
|
| WP1066 |
Influence on protein activity |
Western Blot |
2.50 µM |
Caki-1 |
Homo sapiens |
|
|
|
| WP1066 |
Influence on protein activity |
Western Blot |
5.00 µM |
Caki-1 |
Homo sapiens |
|
|
|
| WP1066 |
Influence on protein activity |
Western Blot |
2.50 µM |
786-O |
Homo sapiens |
|
|
|
| WP1066 |
Influence on protein activity |
Western Blot |
5.00 µM |
786-O |
Homo sapiens |
|
|
|
| WP1066 |
Influence on cell viability |
MTS |
1.00 µM |
Caki-1 |
Homo sapiens |
|
|
|
| WP1066 |
Influence on cell viability |
MTS |
2.50 µM |
Caki-1 |
Homo sapiens |
|
|
|
| WP1066 |
Influence on cell viability |
MTS |
5.00 µM |
Caki-1 |
Homo sapiens |
|
|
|
| WP1066 |
Influence on cell viability |
MTS |
10.00 µM |
Caki-1 |
Homo sapiens |
|
|
|
| WP1066 |
Influence on cell viability |
MTS |
1.00 µM |
786-O |
Homo sapiens |
|
|
|
| WP1066 |
Influence on cell viability |
MTS |
2.50 µM |
786-O |
Homo sapiens |
|
|
|
| WP1066 |
Influence on cell viability |
MTS |
5.00 µM |
786-O |
Homo sapiens |
|
|
|
