WP1066

Name Value
Weight 356.223 g/mol
Zinc ID ZINC13983221
Smiles C[C@H](NC(=O)/C(C#N)=C/c1cccc(Br)n1)c1ccccc1
Molecular formula C17H14BrN3O
Mode of inhibition JAK2, STAT3; Non-peptide small molecule
CAS 857064-38-1

Clinical Trials

Study title Status Conditions Link
STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain Recruiting Metastatic Malignant Neoplasm in the Brain|Metastatic Melanoma|Recurrent Brain Neoplasm|Recurrent Glioblastoma|Recurrent Malignant Glioma NCT01904123

References

Publication DOI Pubmed PMCID
Antral somatostatin contents and acidity of gastric juice in normal subjects and patients with duodenal ulcer. Hiroshima journal of medical sciences K Sumii, M Sumioka, K Hirata, N Uemura, A Tari, M Yoshihara, M Sekito, T Tokutomi, Y Inaba, H Teshima, 35, 4, None, None, 10.1038/sj.bjc.6605691 10.1038/sj.bjc.6605691 2883159 PMC2883159
Evidence that Y-organs of the crab Cancer antennarius secrete 3-dehydroecdysone. Molecular and cellular endocrinology E Spaziani, H H Rees, W L Wang, R D Watson, 66, 1, None, None, 10.1158/1078-0432.CCR-08-0377 10.1158/1078-0432.CCR-08-0377 2583362 PMC2583362
[Parasite egg development during methane fermentation]. Veterinarno-meditsinski nauki Ts S Tsanov, N Petkov, 22, 4, None, None, 10.1371/journal.pone.0095993 10.1371/journal.pone.0095993 4013079 PMC4013079

Vendors

Company Lnk to product
Caymanchemical https://www.caymanchem.com/product/14736/wp1066
Selleckchem https://www.selleckchem.com/products/wp1066.html
MedChemExpress https://www.medchemexpress.com/WP1066.html
MERCK (Sigma Aldrich) https://www.merckmillipore.com/PL/pl/product/STAT3-Inhibitor-III-WP1066,EMD_BIO-573097?ReferrerURL=https%3A%2F%2Fwww.google.com%2F&bd=1
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/mm/573097?lang=pl&region=PL
APExBIO https://www.apexbt.com/wp1066.html
Santa Cruz Biotechnology https://www.scbt.com/p/stat3-inhibitor-iii-wp1066-857064-38-1

Filter data

Compound WP1066
Experiment types ELISA, Flow cytometry- Annexin, Immunohistochemistry, Immunostaining , MTS, Percent survival, Real-time qPCR, Trypan Blue staining , Tube formation, Tumor size , Tumor volume, Western Blot
Concentrations 0.00, 0.01, 0.10, 1.00, 1.25, 10.00, 2.00, 2.50, 20.00, 40.00, 5.00
Cell lines 786-O, A375, AGS, B16, B16 (xenograft), B16EGFRvIII, B16EGFRvIII (xenograft), Caki-1, Caki-1 (xenograft), HUVECS, antral stomach tissue, gp130757FF tumor tissue
Organisms Homo sapiens, Mus musculus
Animal models C57BL/6J, athymic male nude, gp130 757FF mice
STAT proteins STAT3, p-STAT3
Other AKT, Actin, Bcl-2, Bcl-xL, CD34, COX2, Caspase 3, Cleaved PARP, EGFRvIII, ERK, ERK1/2, GAPDH, HIF1α, HIF2α, IL-11, IL-1α, IL-1β, IL-6, JAK2, Ki-67, MCL-1, MCP-1, RANTES, SHP2, Survivin, TGF-β, VEGF, c-Myc, p-AKT, p-Akt, p-ERK, p-ERK1/2, p-JAK2, p-SHP2, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
WP1066 Western Blot Influence on protein activity 2.50 µM Caki-1 Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM Caki-1 Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 2.50 µM Caki-1 Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM Caki-1 Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 2.50 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on protein activity 2.50 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on protein activity 2.50 µM 786-O Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM 786-O Homo sapiens
WP1066 MTS Influence on cell viability 1.00 µM Caki-1 Homo sapiens
WP1066 MTS Influence on cell viability 2.50 µM Caki-1 Homo sapiens
WP1066 MTS Influence on cell viability 5.00 µM Caki-1 Homo sapiens
WP1066 MTS Influence on cell viability 10.00 µM Caki-1 Homo sapiens
WP1066 MTS Influence on cell viability 1.00 µM 786-O Homo sapiens
WP1066 MTS Influence on cell viability 2.50 µM 786-O Homo sapiens
WP1066 MTS Influence on cell viability 5.00 µM 786-O Homo sapiens
WP1066 MTS Influence on cell viability 10.00 µM 786-O Homo sapiens
WP1066 MTS Influence on cell proliferation 5.00 µM Caki-1 Homo sapiens
WP1066 MTS Influence on cell proliferation 2.50 µM Caki-1 Homo sapiens
WP1066 MTS Influence on cell proliferation 5.00 µM 786-O Homo sapiens
WP1066 MTS Influence on cell proliferation 2.50 µM 786-O Homo sapiens
WP1066 Flow cytometry- Annexin Influence on cell apoptosis 5.00 µM Caki-1 Homo sapiens
WP1066 Flow cytometry- Annexin Influence on cell apoptosis 2.50 µM Caki-1 Homo sapiens
WP1066 Flow cytometry- Annexin Influence on cell apoptosis 5.00 µM 786-O Homo sapiens
WP1066 Flow cytometry- Annexin Influence on cell apoptosis 2.50 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on cell apoptosis 2.50 µM 786-O Homo sapiens
WP1066 ELISA Influence on protein activity in hypoxia 5.00 µM Caki-1 Homo sapiens
WP1066 ELISA Influence on protein activity in hypoxia 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM Caki-1 Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM 786-O Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM Caki-1 Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM 786-O Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM 786-O Homo sapiens
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM Caki-1 Homo sapiens
WP1066 Western Blot Influence on protein activity in hypoxia 5.00 µM 786-O Homo sapiens
WP1066 Tube formation Influence on angiogenesis in hypoxia 5.00 µM HUVECS Homo sapiens
WP1066 Tumor volume Influence on tumor growth 40.00 mg/kg Caki-1 (xenograft) Mus musculus athymic male nude
WP1066 Immunohistochemistry Influence on tumor growth 40.00 mg/kg Caki-1 (xenograft) Mus musculus athymic male nude p-STAT3
WP1066 Immunohistochemistry Influence on tumor growth 40.00 mg/kg Caki-1 (xenograft) Mus musculus athymic male nude STAT3
WP1066 Immunohistochemistry Influence on tumor growth 40.00 mg/kg Caki-1 (xenograft) Mus musculus athymic male nude
WP1066 Western Blot Influence on protein activity 5.00 µM A375 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16EGFRvIII Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM A375 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16EGFRvIII Homo sapiens
WP1066 Western Blot Influence on protein activity 1.25 µM A375 Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 2.50 µM A375 Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM A375 Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 1.25 µM A375 Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 2.50 µM A375 Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM A375 Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 1.25 µM A375 Homo sapiens
WP1066 Western Blot Influence on protein activity 2.50 µM A375 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM A375 Homo sapiens
WP1066 Western Blot Influence on protein activity 1.25 µM A375 Homo sapiens
WP1066 Western Blot Influence on protein activity 2.50 µM A375 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM A375 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16 Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM B16 Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM B16 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16 Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16EGFRvIII Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM B16EGFRvIII Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM B16EGFRvIII Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16EGFRvIII Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM B16EGFRvIII Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 mM B16EGFRvIII Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 mM B16EGFRvIII Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 mM B16EGFRvIII Homo sapiens
WP1066 Tumor volume Influence on tumor growth 40.00 mg/kg B16EGFRvIII (xenograft) Mus musculus C57BL/6J
WP1066 Percent survival Influence on tumor growth 10.00 mg/kg B16EGFRvIII (xenograft) Mus musculus C57BL/6J
WP1066 Percent survival Influence on tumor growth 20.00 mg/kg B16EGFRvIII (xenograft) Mus musculus C57BL/6J
WP1066 Percent survival Influence on tumor growth 40.00 mg/kg B16 (xenograft) Mus musculus C57BL/6J
WP1066 ELISA Influence on cytokine secretion 0.00 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.01 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.10 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 1.00 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.00 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.01 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.10 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 1.00 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.00 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.01 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.10 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 1.00 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.00 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.01 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.10 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 1.00 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.00 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.01 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.10 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 1.00 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.00 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.01 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.10 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 1.00 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.00 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.01 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.10 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 1.00 µM B16EGFRvIII Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.00 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.01 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 0.10 µM B16 Homo sapiens
WP1066 ELISA Influence on cytokine secretion 1.00 µM B16 Homo sapiens
WP1066 Western Blot Influence on protein activity 1.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 2.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 1.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 2.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 1.00 µM AGS Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 2.00 µM AGS Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM AGS Homo sapiens p-STAT3
WP1066 Western Blot Influence on protein activity 1.00 µM AGS Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 2.00 µM AGS Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 5.00 µM AGS Homo sapiens STAT3
WP1066 Western Blot Influence on protein activity 1.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 2.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 1.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 2.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 1.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 2.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 1.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 2.00 µM AGS Homo sapiens
WP1066 Western Blot Influence on protein activity 5.00 µM AGS Homo sapiens
WP1066 Trypan Blue staining Influence on cell apoptosis 5.00 µM AGS Homo sapiens
WP1066 Flow cytometry- Annexin Influence on cell apoptosis 5.00 µM AGS Homo sapiens
WP1066 Tumor size Influence on cell tumor growth 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Immunostaining Influence on cell proliferation on tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Immunostaining Influence on cell apoptosis on tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice STAT3
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice p-STAT3
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Western Blot Influence on protein activity in tumor tissue 10.00 mg/kg gp130757FF tumor tissue Mus musculus gp130 757FF mice
WP1066 Real-time qPCR Influence on pro-inflammatory gene expression 10.00 mg/kg antral stomach tissue Mus musculus gp130 757FF mice
WP1066 Real-time qPCR Influence on pro-inflammatory gene expression 10.00 mg/kg antral stomach tissue Mus musculus gp130 757FF mice
WP1066 Real-time qPCR Influence on pro-inflammatory gene expression 10.00 mg/kg antral stomach tissue Mus musculus gp130 757FF mice
WP1066 Real-time qPCR Influence on pro-inflammatory gene expression 10.00 mg/kg antral stomach tissue Mus musculus gp130 757FF mice
WP1066 Real-time qPCR Influence on pro-inflammatory gene expression 10.00 mg/kg antral stomach tissue Mus musculus gp130 757FF mice