| S3I-M2001 |
Influence on cell proliferation |
Colony formation assay |
100.00 µM |
Panc-1 |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on DNA |
TUNEL |
50.00 µM |
NIH3T3 |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on DNA |
TUNEL |
50.00 µM |
NIH3T3/v-Src |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on DNA |
TUNEL |
50.00 µM |
HUVEC |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on DNA |
TUNEL |
50.00 µM |
MDA-MB-453 |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on DNA |
TUNEL |
50.00 µM |
MCF-10A |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on DNA |
TUNEL |
50.00 µM |
MDA-MB-231 |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on DNA |
TUNEL |
50.00 µM |
MDA-MB-435 |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on apoptosis |
Flow cytometry |
50.00 µM |
3T3/v-Src/
pcDNA3 |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on apoptosis |
Flow cytometry |
50.00 µM |
3T3/v-Src/
ST3-SH2 |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on apoptosis |
Flow cytometry |
50.00 µM |
3T3/v-Src |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on apoptosis |
Western Blot |
50.00 µM |
NIH3T3/v-Src |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on apoptosis |
Western Blot |
50.00 µM |
MDA-MB-435 |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on apoptosis |
Western Blot |
50.00 µM |
NIH3T3/v-Src |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on apoptosis |
Western Blot |
50.00 µM |
MDA-MB-435 |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on cell motility |
Migration assay |
100.00 µM |
NIH3T3/v-Src |
Mus musculus |
|
|
|
| S3I-M2001 |
Influence on cell motility |
Migration assay |
100.00 µM |
MDA-MB-231 |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on cell motility |
Migration assay |
100.00 µM |
Panc-1 |
Homo sapiens |
|
|
|
| S3I-M2001 |
Influence on tumor growth |
Tumor volume |
5.00 mg/kg |
MDA-MB-231 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| S3I-M2001 |
Influence on tumor growth |
Tumor volume |
10.00 mg/kg |
MDA-MB-231 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| S3I-M2001 |
Influence on tumor growth |
Tumor volume |
20.00 mg/kg |
MDA-MB-231 (xenograft) |
Mus musculus |
athymic nude mice |
|
|
| S3I-M2001 |
Influence on DNA binding in tumor |
EMSA |
5.00 mg/kg |
MDA-MB-231 (xenograft) |
Mus musculus |
athymic nude mice |
STAT3:STAT3 |
|
| S3I-M2001 |
Influence on protein activity in tumor tissue |
Western Blot |
5.00 mg/kg |
MDA-MB-231 (xenograft) |
Mus musculus |
athymic nude mice |
STAT3 |
|
| S3I-M2001 |
Influence on protein activity in tumor tissue |
Western Blot |
5.00 mg/kg |
MDA-MB-231 (xenograft) |
Mus musculus |
athymic nude mice |
p-STAT3(Y705) |
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
p-STAT3(Y705) |
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
p-STAT3(Y705) |
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
p-STAT3(S727) |
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
p-STAT3(S727) |
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
STAT3 |
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on target gene expression in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on target gene expression in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on target gene expression in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on target gene expression in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on target gene expression in presence of IL-6 |
Western Blot |
2.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on target gene expression in presence of IL-6 |
Western Blot |
4.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Luciferase activity |
2.00 µM |
C4-2B |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Luciferase activity |
4.00 µM |
C4-2B |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Luciferase activity |
2.00 µM |
LN-S17 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on protien activity in presence of IL-6 |
Luciferase activity |
4.00 µM |
LN-S17 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on cancer cell migration |
Scratch assay |
1.50 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on cancer cell migration |
Scratch assay |
2.00 µM |
DU145 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on cancer cell migration |
Scratch assay |
1.00 µM |
LN-S17 |
Homo sapiens |
|
|
|
| Sanguinarine |
Influence on cancer cell migration in transfected cells |
Scratch assay |
1.00 µM |
DU145 |
Homo sapiens |
|
|
|
