Sanguinarine

Name Value
Weight 332.335 g/mol
Zinc ID ZINC706
Smiles C[n+]1cc2c3c(ccc2c2ccc4cc5c(cc4c21)OCO5)OCO3
Molecular formula C20H14NO4+
Mode of inhibition Direct JAK2; indirect Src, STAT3; Natural product
CAS 2447-54-3

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Inhibition of Stat3 Activation by Sanguinarine Suppresses Prostate Cancer Cell Growth and Invasion 10.1002/pros.21409 N/A N/A

Vendors

Company Lnk to product
Tocris https://www.tocris.com/products/sanguinarine-chloride_2302
Aobious https://aobious.com/aobious/natural-products/4876-sanguinarine.html
MedChemExpress https://www.medchemexpress.com/Sanguinarine-chloride.html
Santa Cruz Biotechnology https://www.scbt.com/p/sanguinarine-chloride-5578-73-4
Caymanchemical https://www.caymanchem.com/product/16951/sanguinarine-(chloride)
Selleckchem https://www.selleckchem.com/products/sanguinarine.html

Filter data

Compound Sanguinarine
Experiment types Colony formation assay , Invasion assay , Luciferase activity, Scratch assay , Western Blot
Concentrations 0.50, 1.00, 1.50, 2.00, 4.00
Cell lines C4-2B, DU145, LN-S17
Organisms Homo sapiens
Animal models
STAT proteins STAT3, p-STAT3(S727), p-STAT3(Y705)
Other GAPDH, Survivin, c-Myc, p-JAK2, p-SRC(Y419)

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 2.00 µM DU145 Homo sapiens p-STAT3(Y705)
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 4.00 µM DU145 Homo sapiens p-STAT3(Y705)
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 2.00 µM DU145 Homo sapiens p-STAT3(S727)
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 4.00 µM DU145 Homo sapiens p-STAT3(S727)
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 2.00 µM DU145 Homo sapiens STAT3
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 4.00 µM DU145 Homo sapiens STAT3
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 2.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 4.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 2.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 4.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 2.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on protien activity in presence of IL-6 4.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on target gene expression in presence of IL-6 2.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on target gene expression in presence of IL-6 4.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on target gene expression in presence of IL-6 2.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on target gene expression in presence of IL-6 4.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on target gene expression in presence of IL-6 2.00 µM DU145 Homo sapiens
Sanguinarine Western Blot Influence on target gene expression in presence of IL-6 4.00 µM DU145 Homo sapiens
Sanguinarine Luciferase activity Influence on protien activity in presence of IL-6 2.00 µM C4-2B Homo sapiens
Sanguinarine Luciferase activity Influence on protien activity in presence of IL-6 4.00 µM C4-2B Homo sapiens
Sanguinarine Luciferase activity Influence on protien activity in presence of IL-6 2.00 µM LN-S17 Homo sapiens
Sanguinarine Luciferase activity Influence on protien activity in presence of IL-6 4.00 µM LN-S17 Homo sapiens
Sanguinarine Scratch assay Influence on cancer cell migration 1.50 µM DU145 Homo sapiens
Sanguinarine Scratch assay Influence on cancer cell migration 2.00 µM DU145 Homo sapiens
Sanguinarine Scratch assay Influence on cancer cell migration 1.00 µM LN-S17 Homo sapiens
Sanguinarine Scratch assay Influence on cancer cell migration in transfected cells 1.00 µM DU145 Homo sapiens
Sanguinarine Invasion assay Influence on cell motility 0.50 µM DU145 Homo sapiens
Sanguinarine Invasion assay Influence on cell motility 1.00 µM DU145 Homo sapiens
Sanguinarine Colony formation assay Influence on cancer cell growth 1.00 µM DU145 Homo sapiens
Sanguinarine Colony formation assay Influence on cancer cell growth 2.00 µM DU145 Homo sapiens
Sanguinarine Colony formation assay Influence on cancer cell growth 1.00 µM LN-S17 Homo sapiens
Sanguinarine Colony formation assay Influence on cancer cell growth 2.00 µM LN-S17 Homo sapiens