LLL-12

Name Value
Weight 303.295 g/mol
Zinc ID ZINC96908204
Smiles NS(=O)(=O)c1cccc2c1C(=O)c1cccc(O)c1C2=O
Molecular formula C14H9NO5S
Mode of inhibition Direct STAT SH2; Non-peptide small molecule
CAS N/A

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia (New York, N.Y.) Li Lin, Brian Hutzen, Pui-Kai Li, Sarah Ball, Mingxin Zuo, Stephanie DeAngelis, Elizabeth Foust, Matthew Sobo, Lauren Friedman, Deepak Bhasin, Ling Cen, Chenglong Li, Jiayuh Lin, 12, 1, None, None, 10.1593/neo.91196 10.1593/neo.91196 20072652 PMC2805882
LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy. Oncotarget Mingxin Zuo, Chenglong Li, Jiayuh Lin, Milind Javle, 6, 13, 2015-05-10, None, 10.18632/oncotarget.3458 10.18632/oncotarget.3458 25883212 PMC4484430
Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Investigational new drugs Grace-Ifeyinwa Onimoe, Aiguo Liu, Li Lin, Chang-Ching Wei, Eric B Schwartz, Deepak Bhasin, Chenglong Li, James R Fuchs, Pui-kai Li, Peter Houghton, Amanda Termuhlen, Thomas Gross, Jiayuh Lin, 30, 3, None, 2011-02-22, 10.1007/s10637-011-9645-1 10.1007/s10637-011-9645-1 21340507 21340507

Filter data

Compound LLL-12
Experiment types Body weight, Colony formation assay , ELISA, Flow cytometry , Focus formation, Immunofluorescence staining , Light microscopy, Luciferase Assay , MTT, RT-PCR, Tumor volume, Western Blot, Wound healing assay
Concentrations 0.50, 1.00, 10.00, 2.00, 2.50, 20.00, 5.00
Cell lines HH, HMEC, HPAC, HPDE, HSMM, Hep3B, MDA-MB-231, MDA-MB-231 (xenograft), MDA-MB-453, OS-33 (xenograft), Panc-1, SAOS2, SJSA, SJSA (xenograft), SK-BR-3, SNU387, SNU398, SNU398 (xenograft), SNU449, U2OS, U373, U87, WI-38
Organisms Homo sapiens, Mus musculus
Animal models nude mice
STAT proteins STAT1, STAT3, p-STAT1 (Y701), p-STAT3, p-STAT3 (Y705)
Other Bcl-2, Bcl-xL, Cleaved Caspase-3, Cleaved PARP, Cleaved caspase-3, Cyclin D1, DNMT1, Flag, GAPDH, PARP, Survivin, Survivn, VEGF, p-ERK1/2 (T202/Y204), p-Src (Tyr416), p-mTOR (Ser2448)

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SK-BR-3 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPAC Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM U87 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 10.00 µM U87 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 10.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPDE Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HMEC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPDE Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HMEC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HPDE Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HMEC Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HH Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HH Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HH Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM WI-38 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM WI-38 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM WI-38 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM WI-38 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM WI-38 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM WI-38 Homo sapiens
LLL-12 Western Blot Influence on protein activity in presence of IL-6 0.50 µM MDA-MB-453 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in presence of IL-6 1.00 µM MDA-MB-453 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in presence of IL-6 2.00 µM MDA-MB-453 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in presence of IL-6 0.50 µM MDA-MB-453 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in presence of IL-6 1.00 µM MDA-MB-453 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in presence of IL-6 2.00 µM MDA-MB-453 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in presence of IL-6 0.50 µM MDA-MB-453 Homo sapiens
LLL-12 Western Blot Influence on protein activity in presence of IL-6 1.00 µM MDA-MB-453 Homo sapiens
LLL-12 Western Blot Influence on protein activity in presence of IL-6 2.00 µM MDA-MB-453 Homo sapiens
LLL-12 ELISA Influence on protein binding to DNA 10.00 µM SK-BR-3 Homo sapiens STAT1
LLL-12 ELISA Influence on protein binding to DNA 10.00 µM MDA-MB-453 Homo sapiens STAT1
LLL-12 ELISA Influence on protein binding to DNA 10.00 µM HPAC Homo sapiens STAT1
LLL-12 ELISA Influence on protein binding to DNA 10.00 µM U87 Homo sapiens STAT1
LLL-12 ELISA Influence on protein binding to DNA 10.00 µM SK-BR-3 Homo sapiens STAT3
LLL-12 ELISA Influence on protein binding to DNA 10.00 µM MDA-MB-453 Homo sapiens STAT3
LLL-12 ELISA Influence on protein binding to DNA 10.00 µM HPAC Homo sapiens STAT3
LLL-12 ELISA Influence on protein binding to DNA 10.00 µM U87 Homo sapiens STAT3
LLL-12 Luciferase Assay Influence on protein activity 1.00 µM MDA-MB-231 Homo sapiens STAT3
LLL-12 Luciferase Assay Influence on protein activity 2.50 µM MDA-MB-231 Homo sapiens STAT3
LLL-12 Luciferase Assay Influence on protein activity 5.00 µM MDA-MB-231 Homo sapiens STAT3
LLL-12 Luciferase Assay Influence on protein activity 10.00 µM MDA-MB-231 Homo sapiens STAT3
LLL-12 RT-PCR Influence on gene expression 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM MDA-MB-231 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM HPAC Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM HPAC Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM HPAC Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM HPAC Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM U373 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM U373 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM U373 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM U373 Homo sapiens
LLL-12 Colony formation assay Influence on cell proliferation 1.00 µM MDA-MB-231 Homo sapiens
LLL-12 Colony formation assay Influence on cell proliferation 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Wound healing assay Influence on cell proliferation 1.00 µM MDA-MB-231 Homo sapiens
LLL-12 Wound healing assay Influence on cell proliferation 2.50 µM MDA-MB-231 Homo sapiens
LLL-12 Wound healing assay Influence on cell proliferation 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 Wound healing assay Influence on cell proliferation 10.00 µM MDA-MB-231 Homo sapiens
LLL-12 Wound healing assay Influence on cell proliferation 20.00 µM MDA-MB-231 Homo sapiens
LLL-12 MTT Influence on cell viability 1.00 µM MDA-MB-231 Homo sapiens
LLL-12 MTT Influence on cell viability 2.50 µM MDA-MB-231 Homo sapiens
LLL-12 MTT Influence on cell viability 5.00 µM MDA-MB-231 Homo sapiens
LLL-12 MTT Influence on cell viability 10.00 µM MDA-MB-231 Homo sapiens
LLL-12 MTT Influence on cell viability 20.00 µM MDA-MB-231 Homo sapiens
LLL-12 Western Blot Influence on protein activity 1.00 µM U87 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 2.50 µM U87 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM U87 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 1.00 µM U87 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 2.50 µM U87 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM U87 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 1.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 2.50 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 1.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 2.50 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 1.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 2.50 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 1.00 µM U87 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 2.50 µM U87 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 5.00 µM U87 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 1.00 µM U87 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 2.50 µM U87 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 5.00 µM U87 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 1.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 2.50 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 5.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 1.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 2.50 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 5.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 1.00 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 2.50 µM U87 Homo sapiens
LLL-12 Western Blot Influence on protein activity in STAT3 transfected cells 5.00 µM U87 Homo sapiens
LLL-12 MTT Influence on cell viability in STAT3 transfected cells 1.00 µM U87 Homo sapiens
LLL-12 MTT Influence on cell viability in STAT3 transfected cells 2.50 µM U87 Homo sapiens
LLL-12 MTT Influence on cell viability in STAT3 transfected cells 5.00 µM U87 Homo sapiens
LLL-12 Tumor volume Influence on tumor growth 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus
LLL-12 Tumor volume Influence on tumor growth 2.50 mg/kg U87 Mus musculus
LLL-12 Tumor volume Influence on tumor growth 5.00 mg/kg U87 Mus musculus
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus STAT3
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 µM Panc-1 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 µM Panc-1 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 µM Panc-1 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 µM Panc-1 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 µM Panc-1 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 µM Panc-1 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 µM Panc-1 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 µM Panc-1 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens
LLL-12 Western Blot Influence on protein activity in tumor tissue 10.00 µM U373 Homo sapiens
LLL-12 MTT Influence on cell viability 0.50 µM SNU387 Homo sapiens
LLL-12 MTT Influence on cell viability 1.00 µM SNU387 Homo sapiens
LLL-12 MTT Influence on cell viability 2.50 µM SNU387 Homo sapiens
LLL-12 MTT Influence on cell viability 5.00 µM SNU387 Homo sapiens
LLL-12 MTT Influence on cell viability 10.00 µM SNU387 Homo sapiens
LLL-12 MTT Influence on cell viability 0.50 µM SNU398 Homo sapiens
LLL-12 MTT Influence on cell viability 1.00 µM SNU398 Homo sapiens
LLL-12 MTT Influence on cell viability 2.50 µM SNU398 Homo sapiens
LLL-12 MTT Influence on cell viability 5.00 µM SNU398 Homo sapiens
LLL-12 MTT Influence on cell viability 10.00 µM SNU398 Homo sapiens
LLL-12 MTT Influence on cell viability 0.50 µM SNU449 Homo sapiens
LLL-12 MTT Influence on cell viability 1.00 µM SNU449 Homo sapiens
LLL-12 MTT Influence on cell viability 2.50 µM SNU449 Homo sapiens
LLL-12 MTT Influence on cell viability 5.00 µM SNU449 Homo sapiens
LLL-12 MTT Influence on cell viability 10.00 µM SNU449 Homo sapiens
LLL-12 MTT Influence on cell viability 0.50 µM Hep3B Homo sapiens
LLL-12 MTT Influence on cell viability 1.00 µM Hep3B Homo sapiens
LLL-12 MTT Influence on cell viability 2.50 µM Hep3B Homo sapiens
LLL-12 MTT Influence on cell viability 5.00 µM Hep3B Homo sapiens
LLL-12 MTT Influence on cell viability 10.00 µM Hep3B Homo sapiens
LLL-12 Light microscopy Influence on cell viability 5.00 µM SNU387 Homo sapiens
LLL-12 Light microscopy Influence on cell viability 10.00 µM SNU387 Homo sapiens
LLL-12 Light microscopy Influence on cell viability 5.00 µM SNU398 Homo sapiens
LLL-12 Light microscopy Influence on cell viability 10.00 µM SNU398 Homo sapiens
LLL-12 Light microscopy Influence on cell viability 5.00 µM SNU449 Homo sapiens
LLL-12 Light microscopy Influence on cell viability 10.00 µM SNU449 Homo sapiens
LLL-12 Light microscopy Influence on cell viability 5.00 µM Hep3B Homo sapiens
LLL-12 Light microscopy Influence on cell viability 10.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU387 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU398 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SNU449 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 5.00 µM Hep3B Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU387 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU398 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SNU449 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM Hep3B Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM Hep3B Homo sapiens
LLL-12 Flow cytometry Influence on cell cycle 5.00 µM SNU387 Homo sapiens
LLL-12 Flow cytometry Influence on cell cycle 5.00 µM SNU398 Homo sapiens
LLL-12 Flow cytometry Influence on cell cycle 5.00 µM SNU449 Homo sapiens
LLL-12 Flow cytometry Influence on cell cycle 5.00 µM Hep3B Homo sapiens
LLL-12 Immunofluorescence staining Influence on protein activity 5.00 µM SNU387 Homo sapiens p-STAT3
LLL-12 Immunofluorescence staining Influence on protein activity 5.00 µM SNU398 Homo sapiens p-STAT3
LLL-12 Tumor volume Influence on tumor growth 5.00 mg/kg SNU398 (xenograft) Mus musculus nude mice
LLL-12 Body weight Influence on tumor growth 5.00 mg/kg SNU398 (xenograft) Mus musculus nude mice
LLL-12 Western Blot Influence on protein activity 5.00 µM U2OS Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM U2OS Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM U2OS Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM U2OS Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM U2OS Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM U2OS Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SAOS2 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM SAOS2 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM SAOS2 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SAOS2 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SAOS2 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SAOS2 Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 10.00 µM SAOS2 Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 10.00 µM SAOS2 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SAOS2 Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SAOS2 Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SJSA Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM SJSA Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM SJSA Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM SJSA Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SJSA Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 10.00 µM SJSA Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 10.00 µM SJSA Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM SJSA Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HSMM Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 5.00 µM HSMM Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 5.00 µM HSMM Homo sapiens
LLL-12 Western Blot Influence on protein activity 5.00 µM HSMM Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM HSMM Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity 10.00 µM HSMM Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity 10.00 µM HSMM Homo sapiens
LLL-12 Western Blot Influence on protein activity 10.00 µM HSMM Homo sapiens
LLL-12 Flow cytometry Influence on cell apoptosis 10.00 µM SAOS2 Homo sapiens
LLL-12 Flow cytometry Influence on cell apoptosis 10.00 µM SJSA Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SAOS2 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SAOS2 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SJSA Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SAOS2 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SJSA Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SAOS2 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SJSA Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SAOS2 Homo sapiens
LLL-12 RT-PCR Influence on gene expression 10.00 µM SJSA Homo sapiens
LLL-12 Western Blot Influence on protein activity in presence of IL-6 5.00 µM SJSA Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in presence of IL-6 10.00 µM SJSA Homo sapiens p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in presence of IL-6 5.00 µM SJSA Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in presence of IL-6 10.00 µM SJSA Homo sapiens STAT3
LLL-12 Western Blot Influence on protein activity in presence of IL-6 5.00 µM SJSA Homo sapiens
LLL-12 Western Blot Influence on protein activity in presence of IL-6 10.00 µM SJSA Homo sapiens
LLL-12 Western Blot Influence on protein activity in presence of IFNγ 5.00 µM SJSA Homo sapiens p-STAT1 (Y701)
LLL-12 Western Blot Influence on protein activity in presence of IFNγ 10.00 µM SJSA Homo sapiens p-STAT1 (Y701)
LLL-12 Western Blot Influence on protein activity in presence of IFNγ 5.00 µM SJSA Homo sapiens STAT1
LLL-12 Western Blot Influence on protein activity in presence of IFNγ 10.00 µM SJSA Homo sapiens STAT1
LLL-12 Western Blot Influence on protein activity in presence of IFNγ 5.00 µM SJSA Homo sapiens
LLL-12 Western Blot Influence on protein activity in presence of IFNγ 10.00 µM SJSA Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 2.50 µM U2OS Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 5.00 µM U2OS Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 10.00 µM U2OS Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 2.50 µM SAOS2 Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 5.00 µM SAOS2 Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 10.00 µM SAOS2 Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 2.50 µM SJSA Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 5.00 µM SJSA Homo sapiens
LLL-12 Focus formation Influence on cell proliferation 10.00 µM SJSA Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 2.50 µM U2OS Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 5.00 µM U2OS Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 10.00 µM U2OS Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 2.50 µM SAOS2 Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 5.00 µM SAOS2 Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 10.00 µM SAOS2 Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 2.50 µM SJSA Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 5.00 µM SJSA Homo sapiens
LLL-12 Wound healing assay Influence on cell migration 10.00 µM SJSA Homo sapiens
LLL-12 Tumor volume Influence on tumor growth 5.00 mg/kg OS-33 (xenograft) Mus musculus
LLL-12 Tumor volume Influence on tumor growth 5.00 mg/kg SJSA (xenograft) Mus musculus
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg SJSA (xenograft) Mus musculus p-STAT3 (Y705)
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg SJSA (xenograft) Mus musculus STAT3
LLL-12 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg SJSA (xenograft) Mus musculus