Berbamine

Name Value
Weight 608.735 g/mol
Zinc ID ZINC30726840
Smiles COc1cc2c3cc1Oc1c(OC)c(OC)cc4c1[C@@H](Cc1ccc(O)c(c1)Oc1ccc(cc1)C[C@@H]3N(C)CC2)N(C)CC4
Molecular formula C37H40N2O6
Mode of inhibition JAK2, SRC, STAT; Natural product
CAS 478-61-5

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950) Yiping Ren, Limin Lu, Taylor B Guo, Ju Qiu, Yiqing Yang, Ailian Liu, Jingwu Z Zhang, 181, 2, 2008-07-15, None, 10.4049/jimmunol.181.2.1491 10.4049/jimmunol.181.2.1491 18606704 18606704

Vendors

Company Lnk to product
AK Scientific Inc. https://aksci.com/item_detail.php?cat=W1165

Filter data

Compound Berbamine
Experiment types ELISA, Experimental autoimmune encephalomyelitis, Flow cytometry , Histopathology staining- H&E, Immunoprecipitation, Measurement by cpm as detected by a MicroBeta counter, Western Blot
Concentrations 10.00, 15.00, 20.00, 5.00, 50.00
Cell lines CD4+ cells, Spinal cord tissue , Splenocytes
Organisms Mus musculus
Animal models c57BL/6
STAT proteins STAT1, STAT4, STAT6, p-STAT1, p-STAT4, p-STAT6
Other GATA3, IFNγ, IL-10, IL-13, IL-17, IL-4, IL-5, IL-6, JAK2, SLIM, T-bet, TGF-β, TNFα, Tyk2, p-JAK2, p-Tyk2

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Berbamine Experimental autoimmune encephalomyelitis Immunization with MOG35-55 protein 50.00 mg/kg Mus musculus c57BL/6
Berbamine Histopathology staining- H&E Immunization with MOG35-55 protein 50.00 mg/kg Spinal cord tissue Mus musculus c57BL/6
Berbamine Measurement by cpm as detected by a MicroBeta counter Encephalitogenic T cell response 5.00 μg/ml Spinal cord tissue Mus musculus c57BL/6
Berbamine Measurement by cpm as detected by a MicroBeta counter Encephalitogenic T cell response 10.00 μg/ml Spinal cord tissue Mus musculus c57BL/6
Berbamine Measurement by cpm as detected by a MicroBeta counter Encephalitogenic T cell response 15.00 μg/ml Spinal cord tissue Mus musculus c57BL/6
Berbamine Measurement by cpm as detected by a MicroBeta counter Encephalitogenic T cell response 20.00 μg/ml Spinal cord tissue Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine ELISA Cytokine level estimtion 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine Flow cytometry 50.00 mg/kg CD4+ cells Mus musculus c57BL/6
Berbamine Flow cytometry 50.00 mg/kg CD4+ cells Mus musculus c57BL/6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6 STAT1
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6 p-STAT1
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6 p-STAT6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6 STAT6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6 p-STAT4
Berbamine Western Blot Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6 STAT4
Berbamine Immunoprecipitation Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6 STAT4
Berbamine Immunoprecipitation Downregulation of IFNγ 50.00 mg/kg Splenocytes Mus musculus c57BL/6