Atiprimod

Name Value
Weight 336.608 g/mol
Zinc ID ZINC1540226
Smiles CCCC1(CCC)CCC2(CCN(CCCN(CC)CC)C2)CC1
Molecular formula C22H44N2
Mode of inhibition JAK2, JAK3, Nf-κB and STAT; Tyrosine kinase inhibitor
CAS 123018-47-3

Clinical Trials

Study title Status Conditions Link
Study of Atiprimod Treatment for Patients With Advanced Cancer Terminated Advanced Cancer NCT00430014
An Open-Label Study of the Safety and Efficacy of Atiprimod Treatment for Patients With Advanced Cancer Unknown status Advanced Cancer NCT00214838
Safety and Efficacy of Atiprimod Treatment for Patients With Low to Intermediate Grade Neuroendocrine Carcinoma Completed Neuroendocrine Carcinoma NCT00388063
Extension Study of the Safety and Efficacy of Atiprimod Treatment in Neuroendocrine Carcinoma Completed Neuroendocrine Carcinoma NCT00663429
Safety and Efficacy of Atiprimod for Patients With Refractory Multiple Myeloma Completed Multiple Myeloma NCT00086216

References

Publication DOI Pubmed PMCID
Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Molecular cancer therapeutics Sweeta R Choudhari, Muhammad A Khan, Genesis Harris, Donald Picker, Gary S Jacob, Timothy Block, Kunwar Shailubhai, 6, 1, None, None, 10.1158/1535-7163.MCT-06-0561 10.1158/1535-7163.MCT-06-0561 17237271 17237271
Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer. Oncotarget Karine Pozo, Stefan Zahler, Keisuke Ishimatsu, Angela M Carter, Rahul Telange, Chunfeng Tan, Shuaijun Wang, Roswitha Pfragner, Junya Fujimoto, Elizabeth Gardner Grubbs, Masaya Takahashi, Sarah C Oltmann, James A Bibb, 9, 102, 2018-12-28, 2018-12-28, 10.18632/oncotarget.26480 10.18632/oncotarget.26480 30701022 PMC6340867
Atiprimod blocks STAT3 phosphorylation and induces apoptosis in multiple myeloma cells. British journal of cancer M Amit-Vazina, S Shishodia, D Harris, Q Van, M Wang, D Weber, R Alexanian, M Talpaz, B B Aggarwal, Z Estrov, 93, 1, 2005-07-11, None, 10.1038/sj.bjc.6602637 10.1038/sj.bjc.6602637 15970928 PMC2361492

Vendors

Company Lnk to product
Tocris https://www.tocris.com/products/atiprimod-dihydrochloride_4580

Filter data

Compound Atiprimod
Experiment types Colony Formation , DNA Fragmentation Assay , ELISA, EMSA, Flow cytometry , MTS, MTT Assay , Western Blot
Concentrations 0.20, 0.32, 0.40, 0.60, 0.62, 0.80, 1.00, 1.25, 10.00, 2.00, 2.50, 25.00, 3.00, 4.00, 5.00, 50.00, 6.00, 8.00, N/A
Cell lines AD38, CMK, CMK JAK2WT, FDCP-EpoR JAK2V617F, FDCP-EpoR JAK2WT, G64, HepG2, HepG2.2.15, Huh-7, MM, MM-1, MM-1R, MMI, MMIR, OCI-MY5, RPMI-8266, SET-2, SET-2 JAK2V617F, T cells, U266-B1, U266-BI, expanded erythroid progenitor cells
Organisms Homo sapiens, Homo sapiens (patient), Mus musculus
Animal models patient material
STAT proteins STAT3, STAT5, p-STAT3, p-STAT5
Other AKT, Akt, BCL2, Bcl-2, Bcl-XL, Caspase 3, Caspase-3/7, Cleaved PARP, JAK2, JAK3, Mcl-1, NF-κB, PARP, Procaspase 3, Procaspase 3 , XIAP, p-AKT, p-JAK2, p-JAK3, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Atiprimod MTT Assay 10.00 µM Huh-7 Homo sapiens
Atiprimod MTT Assay 5.00 µM Huh-7 Homo sapiens
Atiprimod MTT Assay 2.50 µM Huh-7 Homo sapiens
Atiprimod MTT Assay 1.25 µM Huh-7 Homo sapiens
Atiprimod MTT Assay 0.62 µM Huh-7 Homo sapiens
Atiprimod MTT Assay 0.32 µM Huh-7 Homo sapiens
Atiprimod MTT Assay 10.00 µM HepG2 Homo sapiens
Atiprimod MTT Assay 5.00 µM HepG2 Homo sapiens
Atiprimod MTT Assay 2.50 µM HepG2 Homo sapiens
Atiprimod MTT Assay 1.25 µM HepG2 Homo sapiens
Atiprimod MTT Assay 0.62 µM HepG2 Homo sapiens
Atiprimod MTT Assay 0.32 µM HepG2 Homo sapiens
Atiprimod MTT Assay 10.00 µM HepG2.2.15 Homo sapiens
Atiprimod MTT Assay 5.00 µM HepG2.2.15 Homo sapiens
Atiprimod MTT Assay 2.50 µM HepG2.2.15 Homo sapiens
Atiprimod MTT Assay 1.25 µM HepG2.2.15 Homo sapiens
Atiprimod MTT Assay 0.62 µM HepG2.2.15 Homo sapiens
Atiprimod MTT Assay 0.32 µM HepG2.2.15 Homo sapiens
Atiprimod Colony Formation 5.00 µM HepG2 Homo sapiens
Atiprimod Colony Formation 2.50 µM HepG2 Homo sapiens
Atiprimod Colony Formation 5.00 µM HepG2.2.15 Homo sapiens
Atiprimod Colony Formation 2.50 µM HepG2.2.15 Homo sapiens
Atiprimod MTT Assay 10.00 µM AD38 Homo sapiens
Atiprimod MTT Assay 5.00 µM AD38 Homo sapiens
Atiprimod MTT Assay 2.50 µM AD38 Homo sapiens
Atiprimod MTT Assay 1.25 µM AD38 Homo sapiens
Atiprimod MTT Assay 0.62 µM AD38 Homo sapiens
Atiprimod MTT Assay 0.32 µM AD38 Homo sapiens
Atiprimod MTT Assay 10.00 µM G64 Homo sapiens
Atiprimod MTT Assay 5.00 µM G64 Homo sapiens
Atiprimod MTT Assay 2.50 µM G64 Homo sapiens
Atiprimod MTT Assay 1.25 µM G64 Homo sapiens
Atiprimod MTT Assay 0.62 µM G64 Homo sapiens
Atiprimod MTT Assay 0.32 µM G64 Homo sapiens
Atiprimod MTT Assay 10.00 µM T cells Homo sapiens
Atiprimod MTT Assay 5.00 µM T cells Homo sapiens
Atiprimod MTT Assay 2.50 µM T cells Homo sapiens
Atiprimod MTT Assay 1.25 µM T cells Homo sapiens
Atiprimod MTT Assay 0.62 µM T cells Homo sapiens
Atiprimod MTT Assay 0.32 µM T cells Homo sapiens
Atiprimod DNA Fragmentation Assay 10.00 µM HepG2 Homo sapiens
Atiprimod DNA Fragmentation Assay 5.00 µM HepG2 Homo sapiens
Atiprimod DNA Fragmentation Assay 2.50 µM HepG2 Homo sapiens
Atiprimod DNA Fragmentation Assay 1.25 µM HepG2 Homo sapiens
Atiprimod DNA Fragmentation Assay 10.00 µM HepG2.2.15 Homo sapiens
Atiprimod DNA Fragmentation Assay 5.00 µM HepG2.2.15 Homo sapiens
Atiprimod DNA Fragmentation Assay 2.50 µM HepG2.2.15 Homo sapiens
Atiprimod DNA Fragmentation Assay 1.25 µM HepG2.2.15 Homo sapiens
Atiprimod Western Blot 5.00 µM HepG2 Homo sapiens
Atiprimod Western Blot 2.50 µM HepG2 Homo sapiens
Atiprimod Western Blot 1.25 µM HepG2 Homo sapiens
Atiprimod Western Blot 0.62 µM HepG2 Homo sapiens
Atiprimod Western Blot 5.00 µM HepG2.2.15 Homo sapiens STAT3
Atiprimod Western Blot 2.50 µM HepG2.2.15 Homo sapiens STAT3
Atiprimod Western Blot 1.25 µM HepG2.2.15 Homo sapiens STAT3
Atiprimod Western Blot 0.62 µM HepG2.2.15 Homo sapiens STAT3
Atiprimod Western Blot 5.00 µM AD38 Homo sapiens STAT3
Atiprimod Western Blot 2.50 µM AD38 Homo sapiens STAT3
Atiprimod Western Blot 1.25 µM AD38 Homo sapiens STAT3
Atiprimod Western Blot 0.62 µM AD38 Homo sapiens STAT3
Atiprimod MTT Assay Influence on cell proliferation 0.20 µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod MTT Assay Influence on cell proliferation 0.40 µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod MTT Assay Influence on cell proliferation 0.60 µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod MTT Assay Influence on cell proliferation 0.80 µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod MTT Assay Influence on cell proliferation 0.20 µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod MTT Assay Influence on cell proliferation 0.40 µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod MTT Assay Influence on cell proliferation 0.60 µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod MTT Assay Influence on cell proliferation 0.80 µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus STAT3
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus STAT5
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens p-STAT5
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens STAT5
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens STAT5
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens STAT5
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens STAT5
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens STAT5
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens STAT5
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 JAK2V617F Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK JAK2WT Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2WT Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM FDCP-EpoR JAK2V617F Mus musculus
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM SET-2 Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod Western Blot Influence on protein activity N/A µM CMK Homo sapiens
Atiprimod MTS Influence on patient derived cell proliferation N/A µM expanded erythroid progenitor cells Homo sapiens patient material
Atiprimod ELISA Influence on cytokine production 3.00 µM MMI
Atiprimod ELISA Influence on cytokine production 3.00 µM MMIR
Atiprimod ELISA Influence on cytokine production 3.00 µM U266-BI
Atiprimod ELISA Influence on cytokine production 3.00 µM OCI-MY5
Atiprimod EMSA Influence on protein-DNA interaction 5.00 µM U266-B1 Homo sapiens
Atiprimod EMSA Influence on protein-DNA interaction 10.00 µM U266-B1 Homo sapiens
Atiprimod EMSA Influence on protein-DNA interaction 25.00 µM U266-B1 Homo sapiens
Atiprimod EMSA Influence on protein-DNA interaction 50.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 8.00 µM U266-B1 Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity 4.00 µM U266-B1 Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity 2.00 µM U266-B1 Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity 1.00 µM U266-B1 Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity 8.00 µM U266-B1 Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity 4.00 µM U266-B1 Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity 2.00 µM U266-B1 Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity 1.00 µM U266-B1 Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity 8.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 1.00 µM U266-B1 Homo sapiens
Atiprimod EMSA Influence on protein-DNA interaction 2.50 µM U266-B1 Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity in presence of IL-6 2.50 µM MM-1 Homo sapiens p-STAT3
Atiprimod Western Blot Influence on protein activity in presence of IL-6 2.50 µM MM-1 Homo sapiens STAT3
Atiprimod Western Blot Influence on protein activity in presence of IL-6 2.50 µM MM-1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 2.00 µM MM-1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 4.00 µM MM-1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 6.00 µM MM-1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 8.00 µM MM-1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 2.00 µM U266-B1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 4.00 µM U266-B1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 6.00 µM U266-B1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 8.00 µM U266-B1 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 2.00 µM OCI-MY5 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 4.00 µM OCI-MY5 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 6.00 µM OCI-MY5 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 8.00 µM OCI-MY5 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 2.00 µM MM-1R Homo sapiens
Atiprimod MTT Assay Influence on cell viability 4.00 µM MM-1R Homo sapiens
Atiprimod MTT Assay Influence on cell viability 6.00 µM MM-1R Homo sapiens
Atiprimod MTT Assay Influence on cell viability 8.00 µM MM-1R Homo sapiens
Atiprimod MTT Assay Influence on cell viability 2.00 µM RPMI-8266 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 4.00 µM RPMI-8266 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 6.00 µM RPMI-8266 Homo sapiens
Atiprimod MTT Assay Influence on cell viability 8.00 µM RPMI-8266 Homo sapiens
Atiprimod ELISA Influence on cytokine receptor production 3.00 µM MMI
Atiprimod ELISA Influence on cytokine receptor production 3.00 µM MMIR
Atiprimod ELISA Influence on cytokine receptor production 3.00 µM U266-BI
Atiprimod ELISA Influence on cytokine receptor production 3.00 µM OCI-MY5
Atiprimod Flow cytometry Influence on cell cycle 6.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 1.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 8.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 1.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 8.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 1.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on protein activity 8.00 µM U266-B1 Homo sapiens
Atiprimod Flow cytometry Influence on cell proliferation 2.00 µM U266-B1 Homo sapiens
Atiprimod Flow cytometry Influence on cell proliferation 4.00 µM U266-B1 Homo sapiens
Atiprimod Flow cytometry Influence on cell proliferation 8.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 1.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 8.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 1.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 8.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 1.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 8.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 1.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 8.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 1.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 2.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 4.00 µM U266-B1 Homo sapiens
Atiprimod Western Blot Influence on cell apoptosis 8.00 µM U266-B1 Homo sapiens
Atiprimod Colony Formation Influence on cell proliferation 1.00 µM MM Homo sapiens (patient)
Atiprimod Colony Formation Influence on cell proliferation 2.00 µM MM Homo sapiens (patient)
Atiprimod Colony Formation Influence on cell proliferation 4.00 µM MM Homo sapiens (patient)
Atiprimod Colony Formation Influence on cell proliferation 8.00 µM MM Homo sapiens (patient)
Atiprimod MTT Assay Influence on cell viability 1.00 µM MM Homo sapiens (patient)
Atiprimod MTT Assay Influence on cell viability 2.00 µM MM Homo sapiens (patient)
Atiprimod MTT Assay Influence on cell viability 4.00 µM MM Homo sapiens (patient)
Atiprimod MTT Assay Influence on cell viability 8.00 µM MM Homo sapiens (patient)