SH5-07

Name Value
Weight 625.616 g/mol
Zinc ID ZINC103251494
Smiles CN(CC(=O)N(Cc1ccc(C2CCCCC2)cc1)c1ccc(C(=O)NO)cc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Molecular formula C29H28F5N3O5S
Mode of inhibition Direct STAT; hydroxamic acid-based compound
CAS 1456632-41-9

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Founder effect in Tay-Sachs disease. American journal of human genetics A G Knudson, 25, 1, None, None, 10.1158/0008-5472.CAN-14-3558 10.1158/0008-5472.CAN-14-3558 4684502 PMC4684502

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
SH5-07 EMSA Influence on protein binding to DNA 0.50 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 1.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 2.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 5.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 10.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 20.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 1.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 3.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 5.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 10.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 20.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 1.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 3.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 5.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 10.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 20.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 1.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 3.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 5.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 10.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 20.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 1.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 3.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 5.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 8.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 10.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 15.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 20.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 8.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH5-07 EMSA Influence on protein binding to DNA in presence of EGF 15.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH5-07 EMSA Influence on protein binding to DNA 1.00 µM U251MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 3.00 µM U251MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 5.00 µM U251MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 8.00 µM U251MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 10.00 µM U251MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 1.00 µM U373MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 3.00 µM U373MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 5.00 µM U373MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 8.00 µM U373MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 10.00 µM U373MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 1.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 3.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 5.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 8.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 10.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 1.00 µM DU145 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 3.00 µM DU145 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 5.00 µM DU145 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 8.00 µM DU145 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 10.00 µM DU145 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 1.00 µM U87MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 3.00 µM U87MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 10.00 µM U87MG Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 1.00 µM SF295 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 3.00 µM SF295 Homo sapiens STAT3:STAT3
SH5-07 EMSA Influence on protein binding to DNA 10.00 µM SF295 Homo sapiens STAT3:STAT3
SH5-07 Western Blot Infleunce on protein activity 1.00 µM U251MG Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 3.00 µM U251MG Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 10.00 µM U251MG Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 1.00 µM U251MG Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 3.00 µM U251MG Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 10.00 µM U251MG Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 1.00 µM U373MG Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 3.00 µM U373MG Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 10.00 µM U373MG Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 1.00 µM U373MG Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 3.00 µM U373MG Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 10.00 µM U373MG Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 1.00 µM MDA-MB-231 Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 3.00 µM MDA-MB-231 Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 10.00 µM MDA-MB-231 Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 5.00 µM U251MG Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 5.00 µM U251MG Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 5.00 µM U373MG Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 5.00 µM U373MG Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 5.00 µM MDA-MB-231 Homo sapiens p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 5.00 µM MDA-MB-231 Homo sapiens STAT3
SH5-07 Western Blot Infleunce on protein activity 5.00 µM NIH3T3/v-Src Mus musculus p-STAT3 (Y705)
SH5-07 Western Blot Infleunce on protein activity 5.00 µM NIH3T3/v-Src Mus musculus STAT3
SH5-07 Luciferase activity Infleunce on protein activity in transfected cells 3.00 µM NIH3T3 pLucTKS3 Mus musculus
SH5-07 Luciferase activity Infleunce on protein activity in transfected cells 8.00 µM NIH3T3 pLucTKS3 Mus musculus
SH5-07 Luciferase activity Infleunce on protein activity in transfected cells 3.00 µM NIH3T3 pLucSRE Mus musculus
SH5-07 Luciferase activity Infleunce on protein activity in transfected cells 8.00 µM NIH3T3 pLucSRE Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM NIH3T3/v-Src Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM NIH3T3/v-Src Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM NIH3T3/v-Src Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM NIH3T3/v-Src Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM NIH3T3/v-Src Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM MDA-MB-231 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM MDA-MB-231 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM MDA-MB-231 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM MDA-MB-231 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM MDA-MB-231 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM DU145 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM DU145 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM DU145 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM DU145 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM DU145 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM Panc-1 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM Panc-1 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM Panc-1 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM Panc-1 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM Panc-1 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM U251MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM U251MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM U251MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM U251MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM U251MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM U373MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM U373MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM U373MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM U373MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM U373MG Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM NIH3T3 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM NIH3T3 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM NIH3T3 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM NIH3T3 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM NIH3T3 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM MEF/ST3KO Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM MEF/ST3KO Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM MEF/ST3KO Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM MEF/ST3KO Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM MEF/ST3KO Mus musculus
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM A2780S Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM A2780S Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM A2780S Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM A2780S Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM A2780S Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM MCF-7 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM MCF-7 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM MCF-7 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM MCF-7 Homo sapiens
SH5-07 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM MCF-7 Homo sapiens
SH5-07 Colony formation assay Influence on cell motility 1.00 µM MDA-MB-231 Homo sapiens
SH5-07 Colony formation assay Influence on cell motility 3.00 µM MDA-MB-231 Homo sapiens
SH5-07 Colony formation assay Influence on cell motility 1.00 µM U251MG Homo sapiens
SH5-07 Colony formation assay Influence on cell motility 3.00 µM U251MG Homo sapiens
SH5-07 Colony formation assay Influence on cell motility 1.00 µM MEF/ST3KO Mus musculus
SH5-07 Colony formation assay Influence on cell motility 3.00 µM MEF/ST3KO Mus musculus
SH5-07 Flow cytometry- propodium iodide Influence on cell cycle 3.00 µM MDA-MB-231 Homo sapiens
SH5-07 Flow cytometry- propodium iodide Influence on cell cycle 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Flow cytometry- propodium iodide Influence on cell cycle 8.00 µM MDA-MB-231 Homo sapiens
SH5-07 Flow cytometry- propodium iodide Influence on cell cycle 5.00 µM U251MG Homo sapiens
SH5-07 Flow cytometry- propodium iodide Influence on cell cycle 3.00 µM MEF/ST3KO Mus musculus
SH5-07 Flow cytometry- propodium iodide Influence on cell cycle 5.00 µM MEF/ST3KO Mus musculus
SH5-07 Flow cytometry- propodium iodide Influence on cell cycle 8.00 µM MEF/ST3KO Mus musculus
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 3.00 µM MDA-MB-231 Homo sapiens
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 8.00 µM MDA-MB-231 Homo sapiens
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 3.00 µM U251MG Homo sapiens
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 5.00 µM U251MG Homo sapiens
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 8.00 µM U251MG Homo sapiens
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 3.00 µM MEF/ST3KO Mus musculus
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 5.00 µM MEF/ST3KO Mus musculus
SH5-07 Flow cytomentry- Annexin V Influence on cell apoptosis 8.00 µM MEF/ST3KO Mus musculus
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM MDA-MB-231 Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM U251MG Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM U251MG Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM U251MG Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM U251MG Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM U251MG Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM U251MG Homo sapiens
SH5-07 Western Blot Influence on expression of proteins downstream target genes 5.00 µM U251MG Homo sapiens
SH5-07 Tumor size Influence on tumor growth 5.00 mg/kg U251MG (xenograft) Mus musculus athymic nude mice
SH5-07 Tumor size Influence on tumor growth 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH5-07 Tumor size Influence on tumor growth 3.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH5-07 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH5-07 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH5-07 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH5-07 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg U251MG (xenograft) Mus musculus athymic nude mice
SH5-07 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg U251MG (xenograft) Mus musculus athymic nude mice
SH5-07 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg U251MG (xenograft) Mus musculus athymic nude mice