SH5-07

Name Value
Weight 625.616 g/mol
Zinc ID ZINC103251494
Smiles CN(CC(=O)N(Cc1ccc(C2CCCCC2)cc1)c1ccc(C(=O)NO)cc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Molecular formula C29H28F5N3O5S
Mode of inhibition Direct STAT; hydroxamic acid-based compound
CAS 1456632-41-9

Clinical Trials

Visualization

References

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/sh5-07.html
MedChemExpress https://www.medchemexpress.com/SH5-07.html
Sigma Aldrich https://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do?ERROR=IPQS
ProbeChem http://www.probechem.com/products_SH5-07.aspx
MedKoo Biosciences https://medkoo.com/products/18626

Filter data

Compound SH5-07
Experiment types Colony formation assay , CyQUANT cell proliferation assay, EMSA, Flow cytomentry- Annexin V, Flow cytometry- propodium iodide, Luciferase activity, Tumor size , Western Blot
Concentrations 0.50, 1.00, 10.00, 15.00, 2.00, 20.00, 3.00, 4.00, 5.00, 6.00, 8.00
Cell lines A2780S, DU145, MCF-7, MDA-MB-231, MDA-MB-231 (xenograft), MEF/ST3KO, NIH3T3, NIH3T3 pLucSRE, NIH3T3 pLucTKS3, NIH3T3/hEGFR, NIH3T3/v-Src, Panc-1, SF295, U251MG, U251MG (xenograft), U373MG, U87MG
Organisms Homo sapiens, Mus musculus
Animal models athymic nude mice
STAT proteins STAT1:STAT1, STAT1:STAT3, STAT3, STAT3:STAT3, STAT5:STAT5, p-STAT3 (Y705)
Other Bcl-2, Bcl-xL, Cyclin D1, GAPDH, Mcl-1, Survivin , c-Myc, β-actin

Experiments