Cryptotanshinone

Name	Value
Weight	296.366 g/mol
Zinc ID	ZINC2109876
Smiles	C[C@H]1COC2=C1C(=O)C(=O)c1c2ccc2c1CCCC2(C)C
Molecular formula	C19H20O3
Mode of inhibition	Direct STAT SH2
CAS	35825-57-1

Clinical Trials

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References

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Publication	DOI	Pubmed	PMCID
Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation. OncoTargets and therapy Yubin Ji, Yichen Liu, Nina Xue, Tingting Du, Liyuan Wang, Rui Huang, Ling Li, Chunhong Yan, Xiaoguang Chen, 12, None, None, 2019-01-29, 10.2147/OTT.S187777	10.2147/OTT.S187777	30774375	PMC6357882
Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation. Cell death & disease Liang Lu, Sulin Zhang, Cuixian Li, Chun Zhou, Dong Li, Peiqing Liu, Min Huang, Xiaoyan Shen, 8, 5, 2017-05-11, 2017-05-11, 10.1038/cddis.2017.174.	10.1038/cddis.2017.174.	28492557	PMC5520699
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells. Cancer medicine Yufei Yang, Yue Cao, Lihua Chen, Fei Liu, Zihao Qi, Xi Cheng, Ziliang Wang, 7, 9, None, 2018-08-09, 10.1002/cam4.1691	10.1002/cam4.1691	30094960	PMC6143944
Cryptotanshinone suppresses the proliferation and induces the apoptosis of pancreatic cancer cells via the STAT3 signaling pathway. Molecular medicine reports Yuqing Ge, Bo Yang, Zhe Chen, Rubin Cheng, 12, 5, None, 2015-09-28, 10.3892/mmr.2015.4379	10.3892/mmr.2015.4379	26459366	26459366
Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro. Molecular and cellular biochemistry Weidong Li, Shakir M Saud, Matthew R Young, Nancy H Colburn, Baojin Hua, 406, 1-2, None, 2015-04-26, 10.1007/s11010-015-2424-0	10.1007/s11010-015-2424-0	25912550	25912550
N/A	N/A	xxx	N/A
Those who serve us. Delaware medical journal R J Bishoff, 42, 12, None, None, 10.1177/0300060516685513	10.1177/0300060516685513	5536615	28222632

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Vendors

Company	Lnk to product
Selleckchem	https://www.selleck.eu/products/Cryptotanshinone.html?gclid=Cj0KCQiAs67yBRC7ARIsAF49CdWBIM6nCiMBmFuh2eyNN-5Wbp04NRN-3TM_RGkJQSXz1ULJ2Bo5LHwaAmLhEALw_wcB
MERCK (Sigma Aldrich)	https://www.sigmaaldrich.com/catalog/product/sigma/c5624?lang=pl&region=PL&gclid=Cj0KCQiAs67yBRC7ARIsAF49CdUzKBLVaLAPxPEOdStCGu0aC1EEyokEFnL--UbQPI2f6KDU9kfRs0caAmG8EALw_wcB
Aktin Chemicals Inc.	http://www.aktinchem.com/product/18/cryptotanshinone-187.html?gclid=Cj0KCQiAs67yBRC7ARIsAF49CdXCiRdrniJkSaMtzk4l4QJnTnk-035Jj5jYb3YVCWinLB51feNE3GMaAsfyEALw_wcB
Tocris	https://www.tocris.com/products/cryptotanshinone_3713
TargetMol	https://www.targetmol.com/compound/Cryptotanshinone
Caymanchemical	https://www.caymanchem.com/product/16987/cryptotanshinone
MedChemExpress	https://www.medchemexpress.com/Cryptotanshinone.html
AK Scientific Inc.	https://aksci.com/item_detail.php?cat=W2147

Filter data

Compound	Cryptotanshinone
Experiment types	Average mice survival, Body weight, BrdU cell proliferation assay, CCK8 assay, Colony Formation , DAPI staining , Flow cytometry , Glucose uptake, Immunofluorescence, Immunohistochemistry, Invasion assay , Lactate production, Luciferase activity, MTT, MTT Assay , RT-qPCR, SEAP spectrophotometry, SUVmax value, Scratch Wound Assay, Tumor size , Tumor volume, Tumor weight, Tyrosine phosphatase activity, Western Blot
Concentrations	0.10, 0.25, 0.30, 0.50, 1.00, 1.25, 10.00, 100.00, 15.00, 2.00, 2.50, 20.00, 25.00, 3.00, 30.00, 40.00, 5.00, 50.00, 6.00, 60.00, 7.50, 80.00, 9.00, N/A
Cell lines	A2780, BxPC‑3, C6, CAES17, EC109, EC109 (xenograft), HCT116, HEK-Blue, HGC27, Hey, Hey(xenograft), LOVO, MKN45, Ovarian cancer patients serum, Ovarian cancer patients tissue, SGC7901, SW480, T98G, U251, U251 SHP-1, U251 SHP-2, U251 TC-PTP, U87, U87 (xenograft)
Organisms	Homo sapiens, Mus musculus
Animal models	BALB/c
STAT proteins	Histon 3 (nuclear), STAT3, STAT3 (nuclear), STAT3 (whole cell), p-STAT3, p-STAT3 (S727), p-STAT3 (Ser727), p-STAT3 (Tyr705), p-STAT3 (Y705), p-STAT3(Y705)
Other	Actin, Bcl-2, Bcl-xL, C-Myc, Cleaved Caspase-3, Cleaved Caspase-7, Cleaved Caspase-9, Cleaved PARP, Cyclin D1, Cyclin E, EGFR, GAPDH, GLUT1, HIF-1α, HK2, JAK1, JAK2, Ki-67, Ki67, LDHA, Mcl-1, PARP, SEAP, SHP-1, SHP-2, SIRT3, Survivin, TC-PTP, XIAP, p-Akt, p-ERK, p-JAK1, p-JAK2, p-SHP2(Y542), p-SHP2(Y580), p-mTOR, p21, p27, pEGFR, pSrc, β-actin, β-tubulin

Experiments

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Compound	Experiment type	Investigated event	Concentration	Cell line	Organism	Animal model	Stat protein	Details
Cryptotanshinone	Western Blot		2.50 µM	SGC7901	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		5.00 µM	SGC7901	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		7.50 µM	SGC7901	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		10.00 µM	SGC7901	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		15.00 µM	SGC7901	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		20.00 µM	SGC7901	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		2.50 µM	MKN45	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		5.00 µM	MKN45	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		7.50 µM	MKN45	Homo sapiens		STAT3
Cryptotanshinone	Western Blot		10.00 µM	MKN45	Homo sapiens		STAT3

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