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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
Cryptotanshinone Influence on protein activity Western Blot 1.00 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 2.50 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 5.00 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 10.00 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 20.00 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 1.00 µM CAES17 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 2.50 µM CAES17 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 5.00 µM CAES17 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 10.00 µM CAES17 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 20.00 µM CAES17 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity in presence of IL-6 Western Blot 1.00 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity in presence of IL-6 Western Blot 2.50 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity in presence of IL-6 Western Blot 5.00 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity in presence of IL-6 Western Blot 10.00 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity in presence of IL-6 Western Blot 20.00 µM EC109 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity in tumor tissue Western Blot 25.00 mg/kg EC109 (xenograft) Mus musculus BALB/c p-STAT3
Cryptotanshinone Influence on protein activity in tumor tissue Western Blot 50.00 mg/kg EC109 (xenograft) Mus musculus BALB/c p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 10.00 µM BxPC‑3 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 20.00 µM BxPC‑3 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 30.00 µM BxPC‑3 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 40.00 µM BxPC‑3 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 5.00 µM HCT116 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 10.00 µM HCT116 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 25.00 µM HCT116 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 50.00 µM HCT116 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 5.00 µM SW480 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 10.00 µM SW480 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 25.00 µM SW480 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 50.00 µM SW480 Homo sapiens p-STAT3
Cryptotanshinone Influence on protein activity Western Blot 1.25 µM U251 Homo sapiens p-STAT3 (Y705)
Cryptotanshinone Influence on protein activity Western Blot 2.50 µM U251 Homo sapiens p-STAT3 (Y705)
Cryptotanshinone Influence on protein activity Western Blot 5.00 µM U251 Homo sapiens p-STAT3 (Y705)
Cryptotanshinone Influence on protein activity Western Blot 10.00 µM U251 Homo sapiens p-STAT3 (Y705)
Cryptotanshinone Influence on protein activity Western Blot 20.00 µM U251 Homo sapiens p-STAT3 (Y705)
Cryptotanshinone Influence on protein activity in presence of pervanadate Western Blot 10.00 µM U251 Homo sapiens p-STAT3 (Y705)
Cryptotanshinone Influence on protein activity Western Blot 1.25 µM U251 Homo sapiens p-STAT3 (S727)
Cryptotanshinone Influence on protein activity Western Blot 2.50 µM U251 Homo sapiens p-STAT3 (S727)
Cryptotanshinone Influence on protein activity Western Blot 5.00 µM U251 Homo sapiens p-STAT3 (S727)
Cryptotanshinone Influence on protein activity Western Blot 10.00 µM U251 Homo sapiens p-STAT3 (S727)
Cryptotanshinone Influence on protein activity Western Blot 20.00 µM U251 Homo sapiens p-STAT3 (S727)
Cryptotanshinone Influence on protein activity in transfected cells Western Blot 10.00 µM U251 SHP-2 Homo sapiens p-STAT3(Y705)
Cryptotanshinone Influence on protein activity in transfected cells Western Blot 5.00 µM U251 SHP-2 Homo sapiens p-STAT3(Y705)
Cryptotanshinone Influence on protein activity in transfected cells Western Blot 10.00 µM U251 TC-PTP Homo sapiens p-STAT3(Y705)
Cryptotanshinone Influence on protein activity in transfected cells Western Blot 10.00 µM U251 SHP-1 Homo sapiens p-STAT3(Y705)
Cryptotanshinone Influence on protein activity in tumor tissue Immunohistochemistry 30.00 mg/kg U87 (xenograft) Mus musculus BALB/c p-STAT3(Y705)
Cryptotanshinone Influence on protein activity in tumor tissue Immunohistochemistry 60.00 mg/kg U87 (xenograft) Mus musculus BALB/c p-STAT3(Y705)
Cryptotanshinone Influence on protein activity Western Blot 15.00 µM SGC7901 Homo sapiens p-STAT3 (Ser727)
Cryptotanshinone Influence on protein activity Western Blot 15.00 µM MKN45 Homo sapiens p-STAT3 (Ser727)
Cryptotanshinone Influence on protein activity Western Blot 15.00 µM HGC27 Homo sapiens p-STAT3 (Ser727)
Cryptotanshinone Influence on protein activity Western Blot 2.50 µM SGC7901 Homo sapiens p-STAT3 (Ser727)