| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
0.50 µM |
A2058 |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
1.00 µM |
A2058 |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
3.00 µM |
A2058 |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
5.00 µM |
A2058 |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
10.00 µM |
A2058 |
Homo sapiens |
|
p-STAT3(Tyr705) |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
0.50 µM |
A2058 |
Homo sapiens |
|
STAT3 |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
1.00 µM |
A2058 |
Homo sapiens |
|
STAT3 |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
3.00 µM |
A2058 |
Homo sapiens |
|
STAT3 |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
5.00 µM |
A2058 |
Homo sapiens |
|
STAT3 |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
10.00 µM |
A2058 |
Homo sapiens |
|
STAT3 |
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
0.50 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
1.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
3.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
5.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
10.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
0.50 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
1.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
3.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
5.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Inhibition of Jak/STAT signalling in presence of IL-6 |
Western Blot |
10.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on cell apoptosis in presence of IL-6 |
MTS Assay |
5.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
0.10 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
0.50 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
1.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
5.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
10.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
0.10 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
0.50 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
1.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
5.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on JAK2 phosphorylation |
Autophosphorylation kinase activity |
10.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on apoptosis |
Western Blot |
0.50 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on apoptosis |
Western Blot |
1.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on apoptosis |
Western Blot |
5.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on apoptosis |
Western Blot |
10.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on apoptosis |
Western Blot |
0.50 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on apoptosis |
Western Blot |
1.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on apoptosis |
Western Blot |
5.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BBMD3 (berbamine derivative) |
Influence on apoptosis |
Western Blot |
10.00 µM |
A2058 |
Homo sapiens |
|
|
|
| BP-1-102/ 17o |
Influence on proliferation |
Proliferaion Assay |
5.00 µM |
REH-B-ALL |
Mus musculus |
|
|
|
| BP-1-102/ 17o |
Influence on proliferation |
Proliferaion Assay |
5.00 µM |
Burktte |
Mus musculus |
|
|
|
| BP-1-102/ 17o |
Influence on proliferation |
Proliferaion Assay |
5.00 µM |
Jurkat T-ALL |
Mus musculus |
|
|
|
| BP-1-102/ 17o |
Influence on tumor growth |
Individual tumor size |
3.00 mg/kg |
REH tumor |
Mus musculus |
|
|
|
| BP-1-102/ 17o |
Influence on tumor growth |
Mean tumor size |
3.00 mg/kg |
REH tumor |
Mus musculus |
|
|
|
| BP-1-102/ 17o |
Influence on protein |
Western Blot |
5.00 µM |
REH-B-ALL |
Mus musculus |
|
p-STAT3 |
|
| BP-1-102/ 17o |
Influence on protein |
Western Blot |
5.00 µM |
REH-B-ALL |
Mus musculus |
|
STAT3 |
|
| BP-1-102/ 17o |
Influence on gene expression |
RT-qPCR |
5.00 µM |
REH-B-ALL |
Mus musculus |
|
|
|
| BP-1-102/ 17o |
Influence on gene expression |
RT-qPCR |
5.00 µM |
REH-B-ALL |
Mus musculus |
|
|
|
| BP-1-102/ 17o |
Influence on gene expression |
RT-qPCR |
5.00 µM |
REH-B-ALL |
Mus musculus |
|
|
|
| BP-1-102/ 17o |
Influence on gene expression |
RT-qPCR |
2.50 µM |
REH-B-ALL |
Mus musculus |
|
|
|
