| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PCCl3-RET/PTC3 |
Rattus norvegicus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PCCl3-RET/PTC3 |
Rattus norvegicus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
PCCl3-RET/PTC3 |
Rattus norvegicus |
|
|
|
| AZD1480 |
Influence on cell viability |
MTS Assay |
0.50 µM |
786-O |
Mus musclus |
|
|
|
| AZD1480 |
Influence on cell viability |
MTS Assay |
1.00 µM |
786-O |
Mus musclus |
|
|
|
| AZD1480 |
Influence on cell viability |
MTS Assay |
0.50 µM |
Renca |
Mus musclus |
|
|
|
| AZD1480 |
Influence on cell viability |
MTS Assay |
1.00 µM |
Renca |
Mus musclus |
|
|
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
786-O |
Mus musclus |
|
p-STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
786-O |
Mus musclus |
|
p-STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
786-O |
Mus musclus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
786-O |
Mus musclus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
Renca |
Mus musclus |
|
p-STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
Renca |
Mus musclus |
|
p-STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
0.50 µM |
Renca |
Mus musclus |
|
STAT3 |
|
| AZD1480 |
Influence on protein activity |
Western Blot |
1.00 µM |
Renca |
Mus musclus |
|
STAT3 |
|
| AZD1480 |
Influence on cell proliferation in tumor tissue |
Tumor volume |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
p-STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
STAT3 |
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in tumor tissue |
Western Blot |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on angiogenesis |
Immunostaining |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on angiogenesis |
Immunostaining |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on angiogenesis |
Immunostaining |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on angiogenesis |
Immunostaining |
50.00 mg/kg |
Renca (xenograft0 |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on cell motility |
Tube formation assay |
0.10 µM |
EC |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on cell motility |
Tube formation assay |
0.50 µM |
EC |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on cell motility |
Tube formation assay |
1.00 µM |
EC |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on cell motility |
Tube formation assay |
0.10 µM |
HUVEC |
Homo sapiens |
BALB/c |
|
|
| AZD1480 |
Influence on cell motility |
Tube formation assay |
0.50 µM |
HUVEC |
Homo sapiens |
BALB/c |
|
|
| AZD1480 |
Influence on cell motility |
Tube formation assay |
1.00 µM |
HUVEC |
Homo sapiens |
BALB/c |
|
|
| AZD1480 |
Influence on tumor metastasis |
Number of nodules |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
p-STAT3 |
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
STAT3 |
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Influence on protein activity in metastatic tumor |
Western Blot |
50.00 mg/kg |
Renca |
Mus musclus |
BALB/c |
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
0.50 µM |
U266 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
0.50 µM |
RPMI 8226 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
0.50 µM |
Kms.11 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
1.00 µM |
U266 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
1.00 µM |
RPMI 8226 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
1.00 µM |
Kms.11 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
2.00 µM |
U266 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
2.00 µM |
RPMI 8226 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
2.00 µM |
Kms.11 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
3.00 µM |
U266 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
3.00 µM |
RPMI 8226 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell viability inhibition |
MTS Assay |
3.00 µM |
Kms.11 |
Homo sapiens |
|
|
|
| AZD1480 |
Cell Apoptosis Analysis |
Flow cytometry |
0.50 µM |
U266 |
Homo sapiens |
|
|
|
