OPB-31121

Name Value
Weight 0.000 N/A
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT; Non-peptide small molecule
CAS N/A

Clinical Trials

Study title Status Conditions Link
Study to Assess OPB-31121 in Advanced Leukemias or Myelodysplastic Syndromes Terminated Leukemia NCT01029509
STAT3 Inhibitor for Solid Tumors Completed Advanced Cancer|Solid Tumor NCT00955812
Phase 1 Study of OPB-31121 in Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma or Multiple Myeloma Unknown status Non-Hodgkin's Lymphoma(NHL)|Multiple Myeloma(MM) NCT00511082
Phase I/II Study of OPB-31121 in Patients With Progressive Hepatocellular Carcinoma Completed Hepatocellular Carcinoma NCT01406574
An Open-Label Phase-1 Study of OPB-31121 in Patients With Advanced Solid Tumors Unknown status Solid Tumor NCT00657176

References

Publication DOI Pubmed PMCID
Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3). Molecular oncology Lara Brambilla, Davide Genini, Erik Laurini, Jessica Merulla, Laurent Perez, Maurizio Fermeglia, Giuseppina M Carbone, Sabrina Pricl, Carlo V Catapano, 9, 6, None, 2015-03-05, 10.1016/j.molonc.2015.02.012 10.1016/j.molonc.2015.02.012 25777967 PMC5528765
OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer letters Mi-Jung Kim, Hyun-Jin Nam, Hwang-Phill Kim, Sae-Won Han, Seock-Ah Im, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang, 335, 1, 2013-07-10, 2013-02-10, 10.1016/j.canlet.2013.02.010 10.1016/j.canlet.2013.02.010 23402820 23402820

Filter data

Compound OPB-31121
Experiment types Annexin V-FITC staining, Colony formation assay , Immunofluorescence, MTT, TUNEL, Tumor volume, V-FITC assay, Western Blot, Wound healing assay
Concentrations 0.03, 0.30, 0.50, 1.00, 10.00, 100.00, 2.50, 3.00, 30.00, 5.00, 50.00, 60.00, 7.50
Cell lines 7721, 77211, AGS, DLD1, DU145, HCT116, HCT116 (xenograft), Hep3B, HepG2, Huh7, LNCaP, NCI-N87, SNU1, SNU16, SNU216, SNU484, SNU484 (xenograft), SNU5, SNU601, SNU620, SNU638, SNU668, SNU719, SW480
Organisms Homo sapiens, Mus musculus
Animal models SCID mice, nude mice
STAT proteins STAT1, STAT3, STAT5, p-STAT1, p-STAT1 (Y701), p-STAT3 (S727), p-STAT3 (Y705), p-STAT5
Other Actin, Bcl-1, Bcl-2, Bcl-xL, Caspase-3, Cleaved Caspase-3, Cleaved caspase-3, GAPDH, JAK2, Mcl-1, PARP, Survivin, gp130, p-AKT, p-JAK2, α-tubulin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
OPB-31121 Western Blot Infleunce on protein activity 0.50 nM DU145 Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity 1.00 nM DU145 Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity 5.00 nM DU145 Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity 10.00 nM DU145 Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity 50.00 nM DU145 Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity 100.00 nM DU145 Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity 0.50 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity 1.00 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity 5.00 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity 10.00 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity 50.00 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity 100.00 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity 0.50 nM DU145 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity 1.00 nM DU145 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity 5.00 nM DU145 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity 10.00 nM DU145 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity 50.00 nM DU145 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity 100.00 nM DU145 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity 0.50 nM DU145 Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity 1.00 nM DU145 Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity 5.00 nM DU145 Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity 10.00 nM DU145 Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity 50.00 nM DU145 Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity 100.00 nM DU145 Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 1.00 nM LNCaP Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 5.00 nM LNCaP Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 10.00 nM LNCaP Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 50.00 nM LNCaP Homo sapiens STAT3
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 1.00 nM LNCaP Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 5.00 nM LNCaP Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 10.00 nM LNCaP Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 50.00 nM LNCaP Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 1.00 nM LNCaP Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 5.00 nM LNCaP Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 10.00 nM LNCaP Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 50.00 nM LNCaP Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 1.00 nM LNCaP Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 5.00 nM LNCaP Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 10.00 nM LNCaP Homo sapiens
OPB-31121 Western Blot Infleunce on protein activity in presence of IL-6 50.00 nM LNCaP Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.03 µM DU145 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.03 µM LNCaP Homo sapiens
OPB-31121 Colony formation assay Influence on cell proliferation 10.00 nM DU145 Homo sapiens
OPB-31121 Colony formation assay Influence on cell proliferation 50.00 nM DU145 Homo sapiens
OPB-31121 Colony formation assay Influence on cell proliferation 10.00 nM LNCaP Homo sapiens
OPB-31121 Colony formation assay Influence on cell proliferation 50.00 nM LNCaP Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU484 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU484 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU484 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU484 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU484 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU484 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU1 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU1 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU1 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU1 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU1 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU1 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU5 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU5 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU5 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU5 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU5 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU5 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU16 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU16 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU16 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU16 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU16 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU16 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU216 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU216 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU216 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU216 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU216 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU216 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU601 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU601 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU601 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU601 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU601 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU601 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU620 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU620 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU620 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU620 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU620 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU620 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU638 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU638 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU638 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU638 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU638 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU638 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU668 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU668 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU668 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU668 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU668 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU668 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM SNU719 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM SNU719 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM SNU719 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM SNU719 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM SNU719 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM SNU719 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM AGS Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM AGS Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM AGS Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM AGS Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM AGS Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM AGS Homo sapiens
OPB-31121 MTT Influence on cell proliferation 0.30 nM NCI-N87 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 1.00 nM NCI-N87 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 3.00 nM NCI-N87 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 10.00 nM NCI-N87 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 30.00 nM NCI-N87 Homo sapiens
OPB-31121 MTT Influence on cell proliferation 100.00 nM NCI-N87 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens p-STAT3 (S727)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens p-STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens STAT5
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens p-STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 100.00 nM SNU668 Homo sapiens
OPB-31121 V-FITC assay Influence on cell cycle 1.00 nM SNU484 Homo sapiens
OPB-31121 V-FITC assay Influence on cell cycle 10.00 nM SNU484 Homo sapiens
OPB-31121 V-FITC assay Influence on cell cycle 100.00 nM SNU484 Homo sapiens
OPB-31121 V-FITC assay Influence on cell cycle 1.00 nM SNU668 Homo sapiens
OPB-31121 V-FITC assay Influence on cell cycle 10.00 nM SNU668 Homo sapiens
OPB-31121 V-FITC assay Influence on cell cycle 100.00 nM SNU668 Homo sapiens
OPB-31121 Annexin V-FITC staining Influence on cell apoptosis 1.00 nM SNU484 Homo sapiens
OPB-31121 Annexin V-FITC staining Influence on cell apoptosis 10.00 nM SNU484 Homo sapiens
OPB-31121 Annexin V-FITC staining Influence on cell apoptosis 100.00 nM SNU484 Homo sapiens
OPB-31121 Annexin V-FITC staining Influence on cell apoptosis 1.00 nM SNU668 Homo sapiens
OPB-31121 Annexin V-FITC staining Influence on cell apoptosis 10.00 nM SNU668 Homo sapiens
OPB-31121 Annexin V-FITC staining Influence on cell apoptosis 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Influence on cell apoptosis 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 1.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 10.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 100.00 nM SNU484 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 100.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 1.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 10.00 nM SNU668 Homo sapiens
OPB-31121 Western Blot Inflence on protein activity 100.00 nM SNU668 Homo sapiens
OPB-31121 Tumor volume Influence on tumor growth 30.00 mg/kg SNU484 (xenograft) Mus musculus SCID mice
OPB-31121 Tumor volume Influence on tumor growth 60.00 mg/kg SNU484 (xenograft) Mus musculus SCID mice
OPB-31121 Tumor volume Influence on tumor growth 100.00 mg/kg SNU484 (xenograft) Mus musculus SCID mice
OPB-31121 Western Blot Influence on protein activity 1.00 µM HCT116 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 2.50 µM HCT116 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 5.00 µM HCT116 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 1.00 µM HCT116 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 2.50 µM HCT116 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 5.00 µM HCT116 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 1.00 µM HCT116 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 2.50 µM HCT116 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 5.00 µM HCT116 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 µM HCT116 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 2.50 µM HCT116 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 5.00 µM HCT116 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 µM SW480 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 2.50 µM SW480 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 5.00 µM SW480 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity 1.00 µM SW480 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 2.50 µM SW480 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 5.00 µM SW480 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity 1.00 µM SW480 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 2.50 µM SW480 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 5.00 µM SW480 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 1.00 µM SW480 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 2.50 µM SW480 Homo sapiens
OPB-31121 Western Blot Influence on protein activity 5.00 µM SW480 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM 77211 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM 77211 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Huh7 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Huh7 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM HepG2 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM HepG2 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Hep3B Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Hep3B Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM 77211 Homo sapiens STAT3
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM 77211 Homo sapiens STAT3
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Huh7 Homo sapiens STAT3
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Huh7 Homo sapiens STAT3
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM HepG2 Homo sapiens STAT3
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM HepG2 Homo sapiens STAT3
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Hep3B Homo sapiens STAT3
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Hep3B Homo sapiens STAT3
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM 77211 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Huh7 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM HepG2 Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 2.50 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on downstream target genes 5.00 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 µM DLD1 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 2.50 µM DLD1 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM DLD1 Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 µM DLD1 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 2.50 µM DLD1 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM DLD1 Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 µM DLD1 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 2.50 µM DLD1 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM DLD1 Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 2.50 µM Hep3B Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM Hep3B Homo sapiens p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 2.50 µM Hep3B Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM Hep3B Homo sapiens STAT3
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 2.50 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM Hep3B Homo sapiens
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 µM DLD1 Homo sapiens p-STAT1 (Y701)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM DLD1 Homo sapiens p-STAT1 (Y701)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 1.00 µM DLD1 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM DLD1 Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 2.50 µM Hep3B Homo sapiens p-STAT1 (Y701)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM Hep3B Homo sapiens p-STAT1 (Y701)
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 2.50 µM Hep3B Homo sapiens STAT1
OPB-31121 Western Blot Influence on protein activity in presence of IL-6 5.00 µM Hep3B Homo sapiens STAT1
OPB-31121 MTT Influence on cell viability 1.00 µM HCT116 Homo sapiens
OPB-31121 MTT Influence on cell viability 2.50 µM HCT116 Homo sapiens
OPB-31121 MTT Influence on cell viability 5.00 µM HCT116 Homo sapiens
OPB-31121 MTT Influence on cell viability 7.50 µM HCT116 Homo sapiens
OPB-31121 MTT Influence on cell viability 1.00 µM DLD1 Homo sapiens
OPB-31121 MTT Influence on cell viability 2.50 µM DLD1 Homo sapiens
OPB-31121 MTT Influence on cell viability 5.00 µM DLD1 Homo sapiens
OPB-31121 MTT Influence on cell viability 7.50 µM DLD1 Homo sapiens
OPB-31121 MTT Influence on cell viability 1.00 µM SW480 Homo sapiens
OPB-31121 MTT Influence on cell viability 2.50 µM SW480 Homo sapiens
OPB-31121 MTT Influence on cell viability 5.00 µM SW480 Homo sapiens
OPB-31121 MTT Influence on cell viability 7.50 µM SW480 Homo sapiens
OPB-31121 MTT Influence on cell viability 1.00 µM Hep3B Homo sapiens
OPB-31121 MTT Influence on cell viability 2.50 µM Hep3B Homo sapiens
OPB-31121 MTT Influence on cell viability 5.00 µM Hep3B Homo sapiens
OPB-31121 MTT Influence on cell viability 7.50 µM Hep3B Homo sapiens
OPB-31121 MTT Influence on cell viability 1.00 µM Huh7 Homo sapiens
OPB-31121 MTT Influence on cell viability 2.50 µM Huh7 Homo sapiens
OPB-31121 MTT Influence on cell viability 5.00 µM Huh7 Homo sapiens
OPB-31121 MTT Influence on cell viability 7.50 µM Huh7 Homo sapiens
OPB-31121 MTT Influence on cell viability 1.00 µM 7721 Homo sapiens
OPB-31121 MTT Influence on cell viability 2.50 µM 7721 Homo sapiens
OPB-31121 MTT Influence on cell viability 5.00 µM 7721 Homo sapiens
OPB-31121 MTT Influence on cell viability 7.50 µM 7721 Homo sapiens
OPB-31121 Colony formation assay Influence on cell proliferation 2.50 µM Hep3B Homo sapiens
OPB-31121 Colony formation assay Influence on cell proliferation 5.00 µM Hep3B Homo sapiens
OPB-31121 Colony formation assay Influence on cell proliferation 2.50 µM Huh7 Homo sapiens
OPB-31121 Colony formation assay Influence on cell proliferation 5.00 µM Huh7 Homo sapiens
OPB-31121 Wound healing assay Influence on cell motility 2.50 µM Hep3B Homo sapiens
OPB-31121 Wound healing assay Influence on cell motility 5.00 µM Hep3B Homo sapiens
OPB-31121 Wound healing assay Influence on cell motility 2.50 µM Huh7 Homo sapiens
OPB-31121 Wound healing assay Influence on cell motility 5.00 µM Huh7 Homo sapiens
OPB-31121 Immunofluorescence Influence on protein translocation 5.00 µM DLD1 Homo sapiens STAT3
OPB-31121 Immunofluorescence Influence on protein translocation 5.00 µM Hep3B Homo sapiens STAT3
OPB-31121 Tumor volume Influence on tumor growth 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice
OPB-31121 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice p-STAT3 (Y705)
OPB-31121 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice STAT3
OPB-31121 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice
OPB-31121 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice
OPB-31121 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice
OPB-31121 Western Blot Influence on protein activity in tumor tissue 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice
OPB-31121 TUNEL Influence on cell apoptosis 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice STAT3