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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
OPB-31121 Infleunce on protein activity Western Blot 0.50 nM DU145 Homo sapiens STAT3
OPB-31121 Infleunce on protein activity Western Blot 1.00 nM DU145 Homo sapiens STAT3
OPB-31121 Infleunce on protein activity Western Blot 5.00 nM DU145 Homo sapiens STAT3
OPB-31121 Infleunce on protein activity Western Blot 10.00 nM DU145 Homo sapiens STAT3
OPB-31121 Infleunce on protein activity Western Blot 50.00 nM DU145 Homo sapiens STAT3
OPB-31121 Infleunce on protein activity Western Blot 100.00 nM DU145 Homo sapiens STAT3
OPB-31121 Infleunce on protein activity in presence of IL-6 Western Blot 1.00 nM LNCaP Homo sapiens STAT3
OPB-31121 Infleunce on protein activity in presence of IL-6 Western Blot 5.00 nM LNCaP Homo sapiens STAT3
OPB-31121 Infleunce on protein activity in presence of IL-6 Western Blot 10.00 nM LNCaP Homo sapiens STAT3
OPB-31121 Infleunce on protein activity in presence of IL-6 Western Blot 50.00 nM LNCaP Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 1.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 10.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 100.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 1.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 10.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 100.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 1.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 10.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 100.00 nM SNU484 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 1.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 10.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 100.00 nM SNU668 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 1.00 µM HCT116 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 2.50 µM HCT116 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 5.00 µM HCT116 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 1.00 µM SW480 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 2.50 µM SW480 Homo sapiens STAT3
OPB-31121 Influence on protein activity Western Blot 5.00 µM SW480 Homo sapiens STAT3
OPB-31121 Influence on downstream target genes Western Blot 2.50 µM 77211 Homo sapiens STAT3
OPB-31121 Influence on downstream target genes Western Blot 5.00 µM 77211 Homo sapiens STAT3
OPB-31121 Influence on downstream target genes Western Blot 2.50 µM Huh7 Homo sapiens STAT3
OPB-31121 Influence on downstream target genes Western Blot 5.00 µM Huh7 Homo sapiens STAT3
OPB-31121 Influence on downstream target genes Western Blot 2.50 µM HepG2 Homo sapiens STAT3
OPB-31121 Influence on downstream target genes Western Blot 5.00 µM HepG2 Homo sapiens STAT3
OPB-31121 Influence on downstream target genes Western Blot 2.50 µM Hep3B Homo sapiens STAT3
OPB-31121 Influence on downstream target genes Western Blot 5.00 µM Hep3B Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 1.00 µM DLD1 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 2.50 µM DLD1 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 5.00 µM DLD1 Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 2.50 µM Hep3B Homo sapiens STAT3
OPB-31121 Influence on protein activity in presence of IL-6 Western Blot 5.00 µM Hep3B Homo sapiens STAT3
OPB-31121 Influence on protein translocation Immunofluorescence 5.00 µM DLD1 Homo sapiens STAT3
OPB-31121 Influence on protein translocation Immunofluorescence 5.00 µM Hep3B Homo sapiens STAT3
OPB-31121 Influence on protein activity in tumor tissue Western Blot 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice STAT3
OPB-31121 Influence on cell apoptosis TUNEL 5.00 mg/kg HCT116 (xenograft) Mus musculus nude mice STAT3
OPB-31121 Infleunce on protein activity Western Blot 0.50 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Infleunce on protein activity Western Blot 1.00 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Infleunce on protein activity Western Blot 5.00 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Infleunce on protein activity Western Blot 10.00 nM DU145 Homo sapiens p-STAT3 (Y705)
OPB-31121 Infleunce on protein activity Western Blot 50.00 nM DU145 Homo sapiens p-STAT3 (Y705)