Cryptotanshinone

Name Value
Weight 296.366 g/mol
Zinc ID ZINC2109876
Smiles C[C@H]1COC2=C1C(=O)C(=O)c1c2ccc2c1CCCC2(C)C
Molecular formula C19H20O3
Mode of inhibition Direct STAT SH2
CAS 35825-57-1

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Compound Cryptotanshinone
Experiment types Average mice survival, Body weight, BrdU cell proliferation assay, CCK8 assay, Colony Formation , DAPI staining , Flow cytometry , Glucose uptake, Immunofluorescence, Immunohistochemistry, Invasion assay , Lactate production, Luciferase activity, MTT, MTT Assay , RT-qPCR, SEAP spectrophotometry, SUVmax value, Scratch Wound Assay, Tumor size , Tumor volume, Tumor weight, Tyrosine phosphatase activity, Western Blot
Concentrations 0.10, 0.25, 0.30, 0.50, 1.00, 1.25, 10.00, 100.00, 15.00, 2.00, 2.50, 20.00, 25.00, 3.00, 30.00, 40.00, 5.00, 50.00, 6.00, 60.00, 7.50, 80.00, 9.00, N/A
Cell lines A2780, BxPC‑3, C6, CAES17, EC109, EC109 (xenograft), HCT116, HEK-Blue, HGC27, Hey, Hey(xenograft), LOVO, MKN45, Ovarian cancer patients serum, Ovarian cancer patients tissue, SGC7901, SW480, T98G, U251, U251 SHP-1, U251 SHP-2, U251 TC-PTP, U87, U87 (xenograft)
Organisms Homo sapiens, Mus musculus
Animal models BALB/c
STAT proteins Histon 3 (nuclear), STAT3, STAT3 (nuclear), STAT3 (whole cell), p-STAT3, p-STAT3 (S727), p-STAT3 (Ser727), p-STAT3 (Tyr705), p-STAT3 (Y705), p-STAT3(Y705)
Other Actin, Bcl-2, Bcl-xL, C-Myc, Cleaved Caspase-3, Cleaved Caspase-7, Cleaved Caspase-9, Cleaved PARP, Cyclin D1, Cyclin E, EGFR, GAPDH, GLUT1, HIF-1α, HK2, JAK1, JAK2, Ki-67, Ki67, LDHA, Mcl-1, PARP, SEAP, SHP-1, SHP-2, SIRT3, Survivin, TC-PTP, XIAP, p-Akt, p-ERK, p-JAK1, p-JAK2, p-SHP2(Y542), p-SHP2(Y580), p-mTOR, p21, p27, pEGFR, pSrc, β-actin, β-tubulin

Experiments