AZD9150

Name Value
Weight 0.000 g/mol
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition N/A
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Inhibition of STAT3 with the generation 2.5 antisense oligonucleotide, AZD9150, decreases neuroblastoma tumorigenicity and increases chemosensitivity 10.1158/1078-0432.CCR-16-1317 https://pubmed.ncbi.nlm.nih.gov/27797972/ N/A

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens STAT3
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 0.25 µM IMR32 Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 0.50 µM IMR32 Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM IMR32 Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 2.50 µM IMR32 Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 5.00 µM IMR32 Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 10.00 µM IMR32 Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 0.25 µM AS Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 0.50 µM AS Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM AS Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 2.50 µM AS Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 5.00 µM AS Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 10.00 µM AS Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 0.25 µM NGP Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 0.50 µM NGP Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM NGP Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 2.50 µM NGP Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 5.00 µM NGP Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 10.00 µM NGP Homo sapiens STAT3
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM IMR32 Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM AS Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM NGP Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM IMR32 Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM AS Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM NGP Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM IMR32 Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM AS Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM NGP Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM IMR32 Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM AS Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM NGP Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM IMR32 Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM AS Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM NGP Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM IMR32 Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM AS Homo sapiens
AZD9150 RT-PCR Infleunce on mRNA expression level 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM AS Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.25 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 0.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 1.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 2.50 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 5.00 µM IMR32 Homo sapiens
AZD9150 Western Blot Influence on protein activity 10.00 µM IMR32 Homo sapiens
AZD9150 IncuCyte Influence on cell viability 1.00 µM AS Homo sapiens
AZD9150 IncuCyte Influence on cell viability 1.00 µM NGP Homo sapiens
AZD9150 IncuCyte Influence on cell viability 1.00 µM IMR32 Homo sapiens
AZD9150 Colony Formation Influence on cell viability 1.00 µM AS Homo sapiens
AZD9150 Colony Formation Influence on cell viability 1.00 µM NGP Homo sapiens
AZD9150 Colony Formation Influence on cell viability 1.00 µM IMR32 Homo sapiens
AZD9150 Tumor volume Influence on tumor growth 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue 100.00 mg/kg NGP(xenograft) Mus musculus p-STAT3(Ser727)
AZD9150 Western Blot Influence on protein activity in tumor tissue 100.00 mg/kg NGP(xenograft) Mus musculus p-STAT3(Tyr705)
AZD9150 Western Blot Influence on protein activity in tumor tissue 100.00 mg/kg NGP(xenograft) Mus musculus STAT3
AZD9150 Western Blot Influence on protein activity in tumor tissue 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in presence of cisplatin 1.00 µM NGP Homo sapiens
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus
AZD9150 Western Blot Influence on protein activity in tumor tissue in presence of cisplatin 100.00 mg/kg NGP(xenograft) Mus musculus