| Piperlongumine |
Influence on tumor growth |
Tumor volume |
20.00 mg/kg |
PNX0010 (xenograft) |
Mus musculus |
C.B-17/Icr mice |
|
|
| Piperlongumine |
Influence on tumor growth |
Immunohistochemistry |
20.00 mg/kg |
PNX0010 (xenograft) |
Mus musculus |
C.B-17/Icr mice |
|
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Confocal and high-throughput fluorescence microscopy (HTFM) |
0.10 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Confocal and high-throughput fluorescence microscopy (HTFM) |
0.30 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Confocal and high-throughput fluorescence microscopy (HTFM) |
1.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Confocal and high-throughput fluorescence microscopy (HTFM) |
3.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Confocal and high-throughput fluorescence microscopy (HTFM) |
10.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Confocal and high-throughput fluorescence microscopy (HTFM) |
30.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Confocal and high-throughput fluorescence microscopy (HTFM) |
100.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Fluorescence intensity in the nucleus (FLIN) |
0.10 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Fluorescence intensity in the nucleus (FLIN) |
0.30 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Fluorescence intensity in the nucleus (FLIN) |
1.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Fluorescence intensity in the nucleus (FLIN) |
3.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Fluorescence intensity in the nucleus (FLIN) |
10.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Fluorescence intensity in the nucleus (FLIN) |
30.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on protein translocation in presence of IL-6 |
Fluorescence intensity in the nucleus (FLIN) |
100.00 µM |
Stat3−/− MEF |
Mus musculus |
|
STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4400 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4849 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3613B |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3824 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4888 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4175 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3963 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft IBC3 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3807 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3204 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 2277 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4664 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3887 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3107 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 2665 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4169 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3561 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4698 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3143 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3104 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3611 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft MC1 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4913 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3863 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4272 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3904 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4195 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 2147 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft T47D |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft MCF7 |
Mus musculus |
SCID/Beige nude mice |
p-STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4400 |
Mus musculus |
SCID/Beige nude mice |
STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 4849 |
Mus musculus |
SCID/Beige nude mice |
STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3613B |
Mus musculus |
SCID/Beige nude mice |
STAT3 |
|
| Piperlongumine |
Influence on cell apoptosis |
Luminex assay |
30.00 µM |
patient derived xenograft 3824 |
Mus musculus |
SCID/Beige nude mice |
STAT3 |
|
