Name	Value
Compound	Piperlongumine
Investigated event	Influence on protein translocation in presence of IL-6
Experiment type	Fluorescence intensity in the nucleus (FLIN)
Concentration	0.10 µM
Cell line	Stat3−/− MEF
Organism	Mus musculus
Animal model
STAT protein	STAT3
Other

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene U Bharadwaj, T K Eckols, M Kolosov, M M Kasembeli, A Adam, D Torres, X Zhang, L E Dobrolecki, W Wei, M T Lewis, B Dave, J C Chang, M D Landis, C J Creighton, M A Mancini, D J Tweardy, 34, 11, 2015-03-12, 2014-03-31, 10.1038/onc.2014.72 DOI: 10.1038/onc.2014.72 PUBMED: 24681959 PMCID: PMC4182178