| BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        p-STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A375 | 
                        Homo sapiens | 
                         | 
                        p-STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        G361 | 
                        Homo sapiens | 
                         | 
                        p-STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        SK-MEL-5 | 
                        Homo sapiens | 
                         | 
                        p-STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A375 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        G361 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        SK-MEL-5 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A375 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        G361 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        SK-MEL-5 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A375 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        G361 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        SK-MEL-5 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        p-STAT3(Tyr705) | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        p-STAT3(Tyr705) | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        p-STAT3(Tyr705) | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        p-STAT3(Tyr705) | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        1.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        5.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        10.00 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         |