Investigated event: Inhibition of Jak/STAT signalling

Name Value
Compound BBMD3 (berbamine derivative)
Investigated event Inhibition of Jak/STAT signalling
Experiment type Western Blot
Concentration 0.50 µM
Cell line A2058
Organism Homo sapiens
Animal model
STAT protein
Other p-Tyk2(Tyr1054/1055)
Reference
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Molecular oncology Sangkil Nam, Jun Xie, Angela Perkins, Yuelong Ma, Fan Yang, Jun Wu, Yan Wang, Rong-Zhen Xu, Wendong Huang, David A Horne, Richard Jove, 6, 5, None, 2012-06-02, 10.1016/j.molonc.2012.05.002 DOI: 10.1016/j.molonc.2012.05.002 PUBMED: 22717603 PMCID: PMC3439602