| BBMD3 (berbamine derivative) | 
                        Cell viability | 
                        MTS Assay  | 
                        0.50 µM | 
                        NHDF | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        p-STAT3(Tyr705) | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling  | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling in presence of IL-6 | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        p-STAT3(Tyr705) | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling in presence of IL-6 | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                        STAT3 | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling in presence of IL-6 | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Inhibition of Jak/STAT signalling in presence of IL-6 | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Influence on JAK2 phosphorylation | 
                        Autophosphorylation kinase activity | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Influence on JAK2 phosphorylation | 
                        Autophosphorylation kinase activity | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Influence on apoptosis | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         | 
                    
                
                    
                        | BBMD3 (berbamine derivative) | 
                        Influence on apoptosis | 
                        Western Blot | 
                        0.50 µM | 
                        A2058 | 
                        Homo sapiens | 
                         | 
                         | 
                         |