CADPE

Name Value
Weight 284.311 g/mol
Zinc ID ZINC1083
Smiles O=C(/C=C/c1ccc(O)c(O)c1)OCCc1ccccc1
Molecular formula C17H16O4
Mode of inhibition Direct JAK2; indirect STAT3
CAS 104594-70-9

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Caffeic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II in stroke-prone spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension Peng-Gao Li, Jin-Wen Xu, Katsumi Ikeda, Akira Kobayakawa, Yasuyo Kayano, Takahiko Mitani, Takao Ikami, Yukio Yamori, 28, 4, None, None, 10.1291/hypres.28.369 10.1291/hypres.28.369 16138568 16138568
Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells. Carcinogenesis Joo Eun Jung, Hong Sook Kim, Chang Seok Lee, Dae-Hun Park, Yong-Nyun Kim, Min-Jae Lee, Jung Weon Lee, Jong-Wan Park, Myung-Suk Kim, Sang Kyu Ye, Myung-Hee Chung, 28, 8, None, 2007-06-08, 10.1093/carcin/bgm130 10.1093/carcin/bgm130 17557905 17557905
CADPE suppresses cyclin D1 expression in hepatocellular carcinoma by blocking IL-6-induced STAT3 activation. Anticancer research Cheolhee Won, Chang Seok Lee, Jin-Ku Lee, Tack-Joong Kim, Kwang-Ho Lee, Young Mok Yang, Yong-Nyun Kim, Sang-Kyu Ye, Myung-Hee Chung, 30, 2, None, None, N/A N/A 20332458 20332458
Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-κB ligand–induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-activated protein kinase/activator protein 1 and Ca2+–nuclear factor of activated T-cells cytoplasmic 1 signaling pathways. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Xian Wu, Zhenxi Li, Zhengfang Yang, Chunbing Zheng, Ji Jing, Yihua Chen, Xiyun Ye, Xiaoyuan Lian, Wenwei Qiu, Fan Yang, Jie Tang, Jianru Xiao, Mingyao Liu, Jian Luo, 27, 6, None, None, 10.1002/jbmr.1576 10.1002/jbmr.1576 22337253 22337253

Vendors

Company Lnk to product
AK Scientific Inc. https://aksci.com/item_detail.php?cat=I793
AK Scientific Inc. https://aksci.com/item_detail.php?cat=J10785
AK Scientific Inc. https://aksci.com/item_detail.php?cat=J92664
MedChemExpress https://www.medchemexpress.com/Caffeic_acid_phenethyl_ester.html
TargetMol https://www.targetmol.com/compound/Caffeic-Acid-Phenethyl-Ester
MERCK (Sigma Aldrich) https://www.sigmaaldrich.com/catalog/product/sigma/c8221?lang=pl&region=PL
Tocris https://www.tocris.com/products/caffeic-acid-phenethyl-ester_2743
Selleckchem https://www.selleckchem.com/products/caffeic-acid-phenethyl-ester.html
BLDpharm https://www.bldpharm.com/products/104594-70-9.html
MCULE https://mcule.com/MCULE-4178365007/
Ambinter http://www.ambinter.com/reference/Amb10843905
Fluorochem http://www.fluorochem.co.uk/Products/Product?code=212797
Key Organics https://www.keyorganics.net/caffeicacidphenethylester-104594-70-9-c17h16o4.html

Filter data

Compound CADPE
Experiment types Actin-ring formation, Counting by Sample Measurement Unit, Immunohistochemistry, Immunoprecipitation, Immunosorbent assay kit, Luciferase activity, MTT, Matrigel Matrix tube formation assay , Mayer’s hematoxylin, RT-PCR, TRAP assay , Tumor volume, weight, Western Blot
Concentrations 0.10, 0.50, 1.00, 10.00, 100.00, 15.00, 150.00, 2.50, 200.00, 25.00, 30.00, 5.00, 50.00, 70.00
Cell lines BMM, COS7, Caki-I, Caki-I(xenograft), HUVEC, Huh7, RAW264.7, VSMC
Organisms Homo sapiens, Mus musculus, Rattus norvegicus
Animal models SHRSP, WKY, nude mice
STAT proteins STAT1α, STAT1β, STAT3, STAT3YF, p-STAT1α, p-STAT1β, p-STAT3, p-STAT3 (Tyr-705), p-STAT5 (Tyr-694/699)
Other AcH4, CD31, Cyclin D1, ERK1/2, HIF-1α, HSP90, JAK2, LaminB, VEGF, p-ERK1/2, p-JAK2, p-Src(Y416), p300, αtubulin, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus
CADPE Western Blot Influence on proteins levels 10.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on proteins levels 50.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on proteins levels 10.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on proteins levels 50.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus WKY
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus WKY
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP p-STAT1α
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP p-STAT1β
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP STAT1α
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP STAT1β
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on proteins levels 100.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on AngII induced protein 100.00 µM VSMC Rattus norvegicus SHRSP
CADPE Western Blot Influence on AngII induced protein 100.00 µM VSMC Rattus norvegicus SHRSP
CADPE Counting by Sample Measurement Unit Influence on AngII induced proliferation 100.00 µM VSMC Rattus norvegicus SHRSP
CADPE Counting by Sample Measurement Unit Influence on AngII induced proliferation 100.00 µM VSMC Rattus norvegicus WKY
CADPE Western Blot Influence on proteins levels 15.00 µM Caki-I Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels 30.00 µM Caki-I Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels 50.00 µM Caki-I Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels 70.00 µM Caki-I Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels 100.00 µM Caki-I Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels 150.00 µM Caki-I Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels 200.00 µM Caki-I Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels 15.00 µM Caki-I Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels 30.00 µM Caki-I Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels 50.00 µM Caki-I Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels 70.00 µM Caki-I Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels 100.00 µM Caki-I Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels 150.00 µM Caki-I Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels 200.00 µM Caki-I Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels 30.00 µM COS7 Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels 30.00 µM COS7 Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels 30.00 µM COS7 Homo sapiens
CADPE Western Blot Influence on proteins levels timecourse 30.00 µM Caki-I Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on proteins levels timecourse 30.00 µM Caki-I Homo sapiens STAT3
CADPE Western Blot Influence on proteins levels timecourse 30.00 µM Caki-I Homo sapiens
CADPE Western Blot Influence on proteins levels timecourse 30.00 µM Caki-I Homo sapiens
CADPE Luciferase activity Influence on transcriptional activity 30.00 µM COS7 Homo sapiens STAT3
CADPE Luciferase activity Influence on transcriptional activity 30.00 µM Caki-I Homo sapiens STAT3
CADPE Immunoprecipitation Influence on transcriptional activity 30.00 µM Caki-I Homo sapiens p-STAT3
CADPE Immunoprecipitation Influence on transcriptional activity 30.00 µM Caki-I Homo sapiens
CADPE Immunoprecipitation Influence on transcriptional activity 30.00 µM Caki-I Homo sapiens
CADPE Matrigel Matrix tube formation assay Influence on tube formation 30.00 µM HUVEC Homo sapiens
CADPE Immunosorbent assay kit Influence on VEGF secretion under hypoxic conditions 30.00 µM Caki-I Homo sapiens STAT3YF
CADPE Tumor volume, weight Influence on tumor growth 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice
CADPE Immunohistochemistry Influence on endothelial cells 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice p-STAT3
CADPE Immunohistochemistry Influence on endothelial cells 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice
CADPE Immunohistochemistry Influence on endothelial cells 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice
CADPE Western Blot Influence on protein levels in tumor tissue 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice p-STAT3 (Tyr-705)
CADPE Western Blot Influence on protein levels in tumor tissue 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice
CADPE Western Blot Influence on protein levels in tumor tissue 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice
CADPE RT-PCR Influence on RNA levels in tumor tissue 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice
CADPE RT-PCR Influence on RNA levels in tumor tissue 5.00 mg/kg Caki-I(xenograft) Mus musculus nude mice
CADPE MTT Influence on cell proliferation 25.00 µM Huh7 Homo sapiens
CADPE MTT Influence on cell proliferation 50.00 µM Huh7 Homo sapiens
CADPE MTT Influence on cell proliferation 100.00 µM Huh7 Homo sapiens
CADPE RT-PCR Influence on transcriptional activity in presence of IL-6 100.00 µM Huh7 Homo sapiens
CADPE RT-PCR Influence on transcriptional activity in presence of IL-6 100.00 µM Huh7 Homo sapiens
CADPE Western Blot Influence on protein activity in presence of IL-6 15.00 µM Huh7 Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on protein activity in presence of IL-6 30.00 µM Huh7 Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on protein activity in presence of IL-6 50.00 µM Huh7 Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on protein activity in presence of IL-6 100.00 µM Huh7 Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on protein activity in presence of IL-6 15.00 µM Huh7 Homo sapiens STAT3
CADPE Western Blot Influence on protein activity in presence of IL-6 30.00 µM Huh7 Homo sapiens STAT3
CADPE Western Blot Influence on protein activity in presence of IL-6 50.00 µM Huh7 Homo sapiens STAT3
CADPE Western Blot Influence on protein activity in presence of IL-6 100.00 µM Huh7 Homo sapiens STAT3
CADPE Western Blot Influence on protein activity in presence of IL-6 50.00 µM COS7 Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on protein activity in presence of IL-6 50.00 µM COS7 Homo sapiens STAT3
CADPE Western Blot Influence on protein activity in presence of IL-6 50.00 µM COS7 Homo sapiens
CADPE Western Blot Influence on STAT3-dependent expression 50.00 µM Huh7 Homo sapiens
CADPE Western Blot Influence on STAT3-dependent expression 50.00 µM Huh7 Homo sapiens p-STAT3 (Tyr-705)
CADPE Western Blot Influence on STAT3-dependent expression 50.00 µM Huh7 Homo sapiens STAT3
CADPE Luciferase activity Influence on STAT3-dependent expression in presence of IL-6 50.00 µM COS7 Homo sapiens
CADPE Luciferase activity Influence on STAT3-dependent expression in presence of IL-6 50.00 µM Huh7 Homo sapiens
CADPE Immunoprecipitation Influence on STAT3 recruitment 50.00 µM Huh7 Homo sapiens p-STAT3 (Tyr-705)
CADPE Immunoprecipitation Influence on STAT3 recruitment 50.00 µM Huh7 Homo sapiens p-STAT5 (Tyr-694/699)
CADPE Immunoprecipitation Influence on STAT3 recruitment 50.00 µM Huh7 Homo sapiens
CADPE Immunoprecipitation Influence on STAT3 recruitment 50.00 µM Huh7 Homo sapiens
CADPE TRAP assay Influence on cell differentiation 0.10 µM BMM Mus musculus
CADPE TRAP assay Influence on cell differentiation 0.50 µM BMM Mus musculus
CADPE TRAP assay Influence on cell differentiation 1.00 µM BMM Mus musculus
CADPE TRAP assay Influence on cell differentiation 2.50 µM BMM Mus musculus
CADPE TRAP assay Influence on cell differentiation 5.00 µM BMM Mus musculus
CADPE TRAP assay Influence on cell differentiation 0.10 µM RAW264.7 Mus musculus
CADPE TRAP assay Influence on cell differentiation 0.50 µM RAW264.7 Mus musculus
CADPE TRAP assay Influence on cell differentiation 1.00 µM RAW264.7 Mus musculus
CADPE TRAP assay Influence on cell differentiation 2.50 µM RAW264.7 Mus musculus
CADPE TRAP assay Influence on cell differentiation 5.00 µM RAW264.7 Mus musculus
CADPE Actin-ring formation Influence on cell differentiation 5.00 µM BMM Mus musculus
CADPE MTT Influence on cell proliferation 0.50 µM BMM Mus musculus
CADPE MTT Influence on cell proliferation 1.00 µM BMM Mus musculus
CADPE MTT Influence on cell proliferation 5.00 µM BMM Mus musculus
CADPE MTT Influence on cell proliferation 10.00 µM BMM Mus musculus
CADPE MTT Influence on cell proliferation 25.00 µM BMM Mus musculus
CADPE Mayer’s hematoxylin Influence on osteoclast bone resorption 5.00 µM BMM Mus musculus