Brassinin

Name Value
Weight 236.365 g/mol
Zinc ID ZINC2382836
Smiles CSC(=S)NCc1c[nH]c2ccccc12
Molecular formula C11H12N2S2
Mode of inhibition Direct STAT; Natural product
CAS 105748-59-2

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
[Feasibility of using the gentamicin "Farmakhim" in farm animals and determination of its concentration in organs and tissues]. Veterinarno-meditsinski nauki S Vangelov, 11, 10, None, None, 10.18632/oncotarget.3443 10.18632/oncotarget.3443 4467444 PMC4467444

Vendors

Company Lnk to product
Caymanchemicals https://www.caymanchem.com/product/20922
Axon Medchem https://www.axonmedchem.com/product/2489
Abmole http://www.abmole.com/products/brassinin.html
Glixx Laboratories https://www.glixxlabs.com/chemical-products/bioactive-screen-leads-p6/GLXC-11384

Filter data

Compound Brassinin
Experiment types Body weight, EMSA, Flow cytometry- annexin V binding and propidium iodide staining, Immunofluorescence, Immunohistochemistry, MTT Assay , RT-PCR, Tumor volume, Tumor weight, Western Blot, xCELLigence Real-Time Cell Analyzer
Concentrations 100.00, 180.00, 200.00, 25.00, 300.00, 50.00, 75.00
Cell lines A549, A549 (xenograft), DU145, H1299, H460 , K526, MEF, PC-9, SCC4, U266
Organisms Homo sapiens, Mus musculus
Animal models athymic nu/nu
STAT proteins STAT3, p-STAT3, p-STAT3 (Y705)
Other Akt, Bcl-2, Bcl-xL, CD31, COX-2, Caspase-3, Cleaved PARP, Cleaved caspase-3, Cyclin D1, ERK, IAP1, IAP2, JAK1, JAK2, Ki-67, MMP-9, PARP, PIAS-3, Procaspase-3 , SOCS-3, Src, Survivin, VEGF, p-Akt (S473), p-ERK (Thr202/204), p-JAK1 (Y1022/1023), p-JAK2 (Y1007/1008), p-Src (Y416), β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Brassinin Western Blot Influence on protein activity 300.00 µM U266 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity 300.00 µM DU145 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity 300.00 µM A549 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity 300.00 µM K526 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity 300.00 µM SCC4 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity 300.00 µM U266 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity 300.00 µM DU145 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity 300.00 µM A549 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity 300.00 µM K526 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity 300.00 µM SCC4 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity 300.00 µM H460 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity 300.00 µM H460 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity 300.00 µM PC-9 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity 300.00 µM PC-9 Homo sapiens STAT3
Brassinin EMSA Influence on protien nuclear translocation 100.00 µM A549 Homo sapiens STAT3
Brassinin EMSA Influence on protien nuclear translocation 200.00 µM A549 Homo sapiens STAT3
Brassinin EMSA Influence on protien nuclear translocation 300.00 µM A549 Homo sapiens STAT3
Brassinin Western Blot Inlfuence on JAK protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Inlfuence on JAK protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity 300.00 µM H1299 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity 300.00 µM H1299 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity 300.00 µM H1299 Homo sapiens
Brassinin Western Blot Influence on protein activity 300.00 µM H1299 Homo sapiens
Brassinin Western Blot Influece on STAT3 dependent proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influece on STAT3 dependent proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influece on STAT3 dependent proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influece on STAT3 dependent proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influece on STAT3 dependent proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influece on STAT3 dependent proteins 300.00 µM A549 Homo sapiens
Brassinin RT-PCR Influece on STAT3 dependent mRNA expression 100.00 µM A549 Homo sapiens
Brassinin RT-PCR Influece on STAT3 dependent mRNA expression 300.00 µM A549 Homo sapiens
Brassinin RT-PCR Influece on STAT3 dependent mRNA expression 100.00 µM A549 Homo sapiens
Brassinin RT-PCR Influece on STAT3 dependent mRNA expression 300.00 µM A549 Homo sapiens
Brassinin RT-PCR Influece on STAT3 dependent mRNA expression 100.00 µM A549 Homo sapiens
Brassinin RT-PCR Influece on STAT3 dependent mRNA expression 300.00 µM A549 Homo sapiens
Brassinin MTT Assay Influence on cell viability in PIAS-3 silenced cells 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in PIAS-3 silenced cells 300.00 µM A549 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity in PIAS-3 silenced cells 300.00 µM A549 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity in PIAS-3 silenced cells 300.00 µM A549 Homo sapiens
Brassinin Immunofluorescence Influence on cell apoptosis in PIAS-3 silenced cells 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in SOCS-3 transfected cells 300.00 µM A549 Homo sapiens p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity in SOCS-3 transfected cells 300.00 µM A549 Homo sapiens STAT3
Brassinin Western Blot Influence on protein activity in SOCS-3 transfected cells 300.00 µM A549 Homo sapiens
Brassinin Immunofluorescence Influence on cell apoptosis in SOCS-3 transfected cells 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell apoptosis in STAT3 transfected cells 300.00 µM MEF Mus musculus p-STAT3 (Y705)
Brassinin Western Blot Influence on cell apoptosis in STAT3 transfected cells 300.00 µM MEF Mus musculus STAT3
Brassinin Western Blot Influence on cell apoptosis in STAT3 transfected cells 300.00 µM MEF Mus musculus
Brassinin Western Blot Influence on cell apoptosis in STAT3 transfected cells 300.00 µM MEF Mus musculus
Brassinin Western Blot Influence on cell apoptosis in STAT3 transfected cells 300.00 µM MEF Mus musculus
Brassinin xCELLigence Real-Time Cell Analyzer Influence on cell viability 100.00 µM A549 Homo sapiens
Brassinin xCELLigence Real-Time Cell Analyzer Influence on cell viability 300.00 µM A549 Homo sapiens
Brassinin xCELLigence Real-Time Cell Analyzer Influence on cell motility 100.00 µM A549 Homo sapiens
Brassinin xCELLigence Real-Time Cell Analyzer Influence on cell motility 300.00 µM A549 Homo sapiens
Brassinin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on apoptosis protein activity 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 100.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 200.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on cell cycle related proteins 300.00 µM A549 Homo sapiens
Brassinin MTT Assay Influence on cell viability in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin MTT Assay Influence on cell viability in presence of paclitaxel 50.00 µM A549 Homo sapiens
Brassinin MTT Assay Influence on cell viability in presence of paclitaxel 75.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Western Blot Influence on protein activity in presence of paclitaxel 25.00 µM A549 Homo sapiens
Brassinin Tumor volume Influence on cell proliferation in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Tumor volume Influence on cell proliferation in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Tumor weight Influence on cell proliferation in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Tumor weight Influence on cell proliferation in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Body weight Influence on cell proliferation in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Body weight Influence on cell proliferation in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu p-STAT3 (Y705)
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu STAT3
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu STAT3
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Western Blot Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Immunohistochemistry Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu p-STAT3
Brassinin Immunohistochemistry Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu p-STAT3
Brassinin Immunohistochemistry Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Immunohistochemistry Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Immunohistochemistry Influence on protein activity in tumor tissue 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu
Brassinin Immunohistochemistry Influence on protein activity in tumor tissue in presence of paclitaxel 180.00 mg/kg A549 (xenograft) Mus musculus athymic nu/nu