Andrographolide

Name	Value
Weight	350.455 g/mol
Zinc ID	ZINC3881797
Smiles	C=C1CC[C@H]2[C@@](C)(CC[C@@H](O)[C@@]2(C)CO)[C@@H]1C/C=C1/C(=O)OC[C@H]1O
Molecular formula	C20H30O5
Mode of inhibition	Nf-κB, STAT; Natural product
CAS	5508-58-7

Clinical Trials

Show entries

Search:

Study title	Status	Conditions	Link
A Post-marketing Research on Jinyebaidu Granule in Treating Patients With Acute Upper Respiratory Infection	Unknown status	Acute Upper Respiratory Infection	NCT02539277
A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis	Unknown status	Acute Exacerbation of Chronic Bronchitis	NCT03132610
Echinacea and Acute Respiratory Illness	Completed	Acute Respiratory Infections	NCT02003651
Effects of an Adaptogenic Extract on Electrical Activity of the Brain in Elderly Subjects With Cognitive Impairment	Completed	Cognitive Impairment, Mild	NCT03780621
Efficacy Study of Andrographis Paniculata Purified Standardized Extract (ApE) in Patients With Multiple Sclerosis (MS)	Completed	Multiple Sclerosis, Relapsing-Remitting	NCT02280876
Efficacy Study of FANG(30) for Active Rheumatoid Arthritis in Adult Patients	Completed	Arthritis, Rheumatoid	NCT00749645
Efficacy, Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MS	Unknown status	Primary Progressive Multiple Sclerosis\|Multiple Sclerosis, Secondary Progressive	NCT02273635
Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Bronchitis	Unknown status	Acute Bronchitis	NCT03132623
Evaluate the Efficacy and Safety of Andrographolide Sulfonate in Patients With Acute Tonsillitis	Unknown status	Acute Tonsillitis	NCT03134443
Magnesium, Partenium, Andrographis, Co-enzyme Q10 and Riboflavin (PACR) in Migraine Prophylaxis	Recruiting	Migraine Disorders	NCT03190044

Showing 1 to 10 of 14 entries

Previous1 2Next

References

Show entries

Search:

Publication	DOI	Pubmed	PMCID
Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway. Journal of ethnopharmacology Ko-Chen Lee, Hen-Hong Chang, Ying-Hui Chung, Tzung-Yan Lee, 135, 3, 2011-06-01, 2011-04-08, 10.1016/j.jep.2011.03.068	10.1016/j.jep.2011.03.068	21497192	21497192
Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology letters Guo-Qing Bao, Bai-Yong Shen, Chun-Peng Pan, Ya-Jing Zhang, Min-Min Shi, Cheng-Hong Peng, 222, 1, 2013-09-12, 2013-07-08, 10.1016/j.toxlet.2013.06.241	10.1016/j.toxlet.2013.06.241	23845849	23845849
Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth. Genes & cancer Jae Yeon Chun, Ramakumar Tummala, Nagalakshmi Nadiminty, Wei Lou, Chengfei Liu, Joy Yang, Christopher P Evans, Qinghua Zhou, Allen C Gao, 1, 8, None, None, 10.1177/1947601910383416	10.1177/1947601910383416	21442031	PMC3063649
Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin. Biochemical pharmacology Jing Zhou, Choon-Nam Ong, Gang-Min Hur, Han-Ming Shen, 79, 9, 2010-05-01, 2009-12-21, 10.1016/j.bcp.2009.12.014	10.1016/j.bcp.2009.12.014	20026083	20026083

Showing 1 to 4 of 4 entries

Vendors

Company	Lnk to product
Selleckchem	https://www.selleckchem.com/products/Andrographolide.html
Caymanchemicals	https://www.caymanchem.com/product/11679/andrographolide
Tocris	https://www.tocris.com/products/andrographolide_4626
MedChemExpress	https://www.medchemexpress.com/andrographolide.html
Adooq	https://www.adooq.com/andrographolide.html
Santa Cruz Biotechnology	https://www.scbt.com/p/andrographolide-5508-58-7

Filter data

Compound	Andrographolide
Experiment types	Body weight, CCK8 assay, Crystal violet staining , ELISA, Flow cytometry , Flow cytometry- annexin V binding and propidium iodide staining, Immunofluorescence, Immunoprecipitation, Immunostaining , Invasion assay , Luciferase activity, MTT Assay , RT-qPCR, TUNEL, Trypan blue assay , Tumor volume, Tumor weight, Western Blot
Concentrations	1.00, 10.00, 100.00, 15.00, 2.00, 2.50, 20.00, 25.00, 30.00, 4.00, 5.00, 50.00, 7.50
Cell lines	AsPC-1, AsPC-1 (xenograft), BxPC-3, Capan-1, DU145, DU145 (xenograft), HCT116, Hela, HepG2, L-02, LNCaP, MDA-MB-231, PC-3, Panc-1, PzHPV-7, RAW264.7, SW1990
Organisms	Homo sapiens, Mus musculus
Animal models	BALB/c, nude mice
STAT proteins	STAT3, STAT3:gp130, STAT3; cytoplasm, STAT3; nucleus, p-STAT3 (Ser727), p-STAT3 (Tyr705), p-STAT3 (Tyr705); cytoplasm, p-STAT3 (Tyr705); nucleus
Other	AIF, AKT, Bax, Bcl-2, Bcl-xL, COX-2, Caspase-3, Caspase-9, Cleaved Caspase-3, Cox IV, Cyclin D1, Cyclin E, Cyto-C, Cytochrome C (mitochondria), GAPDH , IL-6, JAK2 , Ki-67, Lamin A/C; cytoplasm, Lamin A/C; nucleus, Mcl-1, P21 WAF1, PARP, SOCS1, SOCS3, Src, Survivin, Tubulin, Tubulin; cytoplasm, Tubulin; nucleus, X-IAP, iNOS, p-AKT (Ser473), p-Akt (Ser473), p-JAK1 (Tyr1022), p-JAK2 (Tyr1007/1008), p-JAK2 (Tyr1007/10080, p-Src (Tyr419), p44/42 MAPK, p44/42 p-MAPK, β-actin

Experiments

Show entries

Search:

Compound	Experiment type	Investigated event	Concentration	Cell line	Organism	Animal model	Stat protein	Details
Andrographolide	ELISA	Influence on cytokine secretion	1.00 µM	DU145	Homo sapiens
Andrographolide	ELISA	Influence on cytokine secretion	2.50 µM	DU145	Homo sapiens
Andrographolide	ELISA	Influence on cytokine secretion	5.00 µM	DU145	Homo sapiens
Andrographolide	ELISA	Influence on cytokine secretion	10.00 µM	DU145	Homo sapiens
Andrographolide	ELISA	Influence on cytokine secretion	1.00 µM	PC-3	Homo sapiens
Andrographolide	ELISA	Influence on cytokine secretion	2.50 µM	PC-3	Homo sapiens
Andrographolide	ELISA	Influence on cytokine secretion	5.00 µM	PC-3	Homo sapiens
Andrographolide	ELISA	Influence on cytokine secretion	10.00 µM	PC-3	Homo sapiens
Andrographolide	RT-qPCR	Influence on mRNA expression level	1.00 µM	DU145	Homo sapiens
Andrographolide	RT-qPCR	Influence on mRNA expression level	2.50 µM	DU145	Homo sapiens

Showing 1 to 10 of 386 entries

Previous1 2 3 4 5…39Next