AG490
Name | Value |
---|---|
Weight | 294.310 g/mol |
Zinc ID | ZINC12352668 |
Smiles | N#C/C(=C/c1ccc(O)c(O)c1)C(=O)NCc1ccccc1 |
Molecular formula | C17H14N2O3 |
Mode of inhibition | JAK2, JAK3, STAT; Tyrosine kinase inhibitor |
CAS | 133550-30-8 |

Clinical Trials
References
Vendors
Company | Lnk to product |
---|---|
InvivoGen | https://www.invivogen.com/ag490 |
Tocris | https://www.tocris.com/products/ag-490_0414 |
Selleckchem | https://www.selleckchem.com/products/AG-490.html |
MedChemExpress | https://www.medchemexpress.com/AG-490.html |
MERCK (Sigma Aldrich) | https://www.sigmaaldrich.com/catalog/product/mm/658401?lang=pl®ion=PL |
TargetMol | https://www.targetmol.com/compound/AG-490 |
Axon Medchem | https://www.axonmedchem.com/product/1378 |
Caymanchemical | https://www.caymanchem.com/product/10010311/ag-490 |
BLDpharm | https://www.bldpharm.com/products/133550-30-8.html |
Filter data
Compound | AG490 |
Experiment types | Griess reaction, Hematoxylin and eosin staining , Immunocytochemistry, Immunofluorescence, Immunohistochemical staining, Invasion assay , Laser Doppler, Luciferase promoter assay, MMT, RT-PCR, RT-qPCR, TUNEL, Western Blot |
Concentrations | 1.00, 10.00, 100.00, 20.00, 25.00, 3.00, 30.00, 5.00, 50.00 |
Cell lines | 1774 macrophages, Brain tissue , Pancreatic Acinar Cells , RT4, SW1990, quadriceps |
Organisms | Homo sapiens, Rattus norvegicus |
Animal models | Sprague-Dawley (SD) rats |
STAT proteins | STAT1, STAT1α, STAT3, STAT5, p-STAT1, p-STAT3, p-STAT5 |
Other | Akt, Bax, Bcl-2, Caspase-3, ERK1/2, GADD, GAPDH, GPx, GR, HMGB1, HMGB1 (cytoplasm), HMGB1 (nucleus), HO-1, IL-10, JAK2, JNK, LMNB1, MMP-2, NF-κB, NOQ1, TNF-α, Unc5b, VEGF, gp130, iNOS, p-Akt, p-ERK1/2, p-JAK2, p-JNK, peIF2a, β-actin, β-tubulin |