SH4-54

Name Value
Weight 610.601 g/mol
Zinc ID ZINC103251492
Smiles CN(CC(=O)N(Cc1ccc(C2CCCCC2)cc1)c1ccc(C(=O)O)cc1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F
Molecular formula C29H27F5N2O5S
Mode of inhibition Direct STAT DBD; Non-peptide small molecule
CAS 1456632-40-8

Clinical Trials

Study title Status Conditions Link

Visualization

References

Publication DOI Pubmed PMCID
Founder effect in Tay-Sachs disease. American journal of human genetics A G Knudson, 25, 1, None, None, 10.1158/0008-5472.CAN-14-3558 10.1158/0008-5472.CAN-14-3558 4684502 PMC4684502

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/sh-4-54.html
MedChemExpress https://www.medchemexpress.com/SH-4-54.html
Caymanchemical https://www.caymanchem.com/product/25982/sh-4-54
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/mm/509105?lang=pl&region=PL
APExBIO https://www.apexbt.com/sh-4-54.html
BioVision https://www.biovision.com/sh-4-284.html
Adooq Bioscience https://www.adooq.com/sh-4-54.html

Filter data

Compound SH4-54
Experiment types Colony formation assay , CyQUANT cell proliferation assay, EMSA, NMR, Surface plasmon resonance analysis, Tumor size , Western Blot
Concentrations 1.00, 10.00, 15.00, 2.00, 20.00, 3.00, 4.00, 5.00, 6.00, 8.00, N/A
Cell lines A2780S, DU145, MDA-MB-231, MDA-MB-231 (xenograft), MEF/ST3KO, NIH3T3, NIH3T3/hEGFR, NIH3T3/v-Src, Panc-1, SF295, U251MG, U251MG (xenograft), U373MG, U87MG
Organisms Homo sapiens, Mus musculus
Animal models athymic nude mice
STAT proteins STAT1:STAT1, STAT1:STAT3, STAT3, STAT3:STAT3, STAT3:STAT3 (nuclear), STAT5:STAT5, p-STAT3(Y705)
Other Cyclin D1, EGFR, ERK1/2, c-Myc, p-EGFR(Y1068), p-ERK1/2, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 5.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 15.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 20.00 µM NIH3T3/v-Src Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 5.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 20.00 µM NIH3T3/hEGFR Mus musculus STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH4-54 EMSA Influence on protein binding to DNA 5.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH4-54 EMSA Influence on protein binding to DNA 20.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT3
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH4-54 EMSA Influence on protein binding to DNA 5.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH4-54 EMSA Influence on protein binding to DNA 20.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH4-54 EMSA Influence on protein binding to DNA 5.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH4-54 EMSA Influence on protein binding to DNA 8.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH4-54 EMSA Influence on protein binding to DNA 15.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH4-54 EMSA Influence on protein binding to DNA 20.00 µM NIH3T3/hEGFR Mus musculus STAT5:STAT5
SH4-54 EMSA Influence on protein binding to DNA 8.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH4-54 EMSA Influence on protein binding to DNA 15.00 µM NIH3T3/hEGFR Mus musculus STAT1:STAT1
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM U251MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM U373MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM DU145 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM U251MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM U373MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM DU145 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM U251MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM U373MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM DU145 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM U87MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM U87MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM U87MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 1.00 µM SF295 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 3.00 µM SF295 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 10.00 µM SF295 Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 5.00 µM U251MG Homo sapiens STAT3:STAT3
SH4-54 EMSA Influence on protein binding to DNA 5.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH4-54 Western Blot Influence on protein activty 1.00 µM U251MG Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 3.00 µM U251MG Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 10.00 µM U251MG Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 1.00 µM U373MG Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 3.00 µM U373MG Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 10.00 µM U373MG Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 1.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 3.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 10.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 1.00 µM U251MG Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 3.00 µM U251MG Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 10.00 µM U251MG Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 1.00 µM U373MG Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 3.00 µM U373MG Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 10.00 µM U373MG Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 1.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 3.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 10.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 5.00 µM U251MG Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 5.00 µM U373MG Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 5.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 5.00 µM U251MG Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 5.00 µM U373MG Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 5.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Western Blot Influence on protein activty 8.00 µM NIH3T3/v-Src Mus musculus p-STAT3(Y705)
SH4-54 Western Blot Influence on protein activty 8.00 µM NIH3T3/v-Src Mus musculus STAT3
SH4-54 Western Blot Influence on proetin acivity in presnce of EGF 10.00 µM NIH3T3/hEGFR Mus musculus p-STAT3(Y705)
SH4-54 Western Blot Influence on proetin acivity in presnce of EGF 10.00 µM NIH3T3/hEGFR Mus musculus STAT3
SH4-54 Western Blot Influence on proetin acivity in presnce of EGF 10.00 µM NIH3T3/hEGFR Mus musculus
SH4-54 Western Blot Influence on proetin acivity in presnce of EGF 10.00 µM NIH3T3/hEGFR Mus musculus
SH4-54 Western Blot Influence on proetin acivity in presnce of EGF 10.00 µM NIH3T3/hEGFR Mus musculus
SH4-54 Western Blot Influence on proetin acivity in presnce of EGF 10.00 µM NIH3T3/hEGFR Mus musculus
SH4-54 Western Blot Influence on proetin acivity in presnce of EGF 10.00 µM NIH3T3/hEGFR Mus musculus
SH4-54 Western Blot Influence on proetin acivity in presnce of IL-6 10.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Western Blot Influence on proetin acivity in presnce of IL-6 10.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Surface plasmon resonance analysis Protein interaction with inhibitor N/A N/A
SH4-54 NMR Protein interaction with inhibitor N/A N/A
SH4-54 EMSA Influence on protein binding to DNA 8.00 µM U251MG Homo sapiens STAT3:STAT3 (nuclear)
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM NIH3T3/v-Src Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM NIH3T3/v-Src Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM NIH3T3/v-Src Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM NIH3T3/v-Src Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM NIH3T3/v-Src Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM MDA-MB-231 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM MDA-MB-231 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM MDA-MB-231 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM MDA-MB-231 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM MDA-MB-231 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM DU145 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM DU145 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM DU145 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM DU145 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM DU145 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM Panc-1 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM Panc-1 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM Panc-1 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM Panc-1 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM Panc-1 Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM U251MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM U251MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM U251MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM U251MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM U251MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM U373MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM U373MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM U373MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM U373MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM U373MG Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM NIH3T3 Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM NIH3T3 Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM NIH3T3 Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM NIH3T3 Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM NIH3T3 Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM MEF/ST3KO Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM MEF/ST3KO Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM MEF/ST3KO Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM MEF/ST3KO Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM MEF/ST3KO Mus musculus
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 2.00 µM A2780S Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 4.00 µM A2780S Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 6.00 µM A2780S Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 8.00 µM A2780S Homo sapiens
SH4-54 CyQUANT cell proliferation assay Influence on cell viability 10.00 µM A2780S Homo sapiens
SH4-54 Colony formation assay Influence on cell viability 1.00 µM MDA-MB-231 Homo sapiens
SH4-54 Colony formation assay Influence on cell viability 3.00 µM MDA-MB-231 Homo sapiens
SH4-54 Colony formation assay Influence on cell viability 5.00 µM MDA-MB-231 Homo sapiens
SH4-54 Colony formation assay Influence on cell viability 1.00 µM U251MG Homo sapiens
SH4-54 Colony formation assay Influence on cell viability 3.00 µM U251MG Homo sapiens
SH4-54 Colony formation assay Influence on cell viability 1.00 µM MEF/ST3KO Mus musculus
SH4-54 Colony formation assay Influence on cell viability 3.00 µM MEF/ST3KO Mus musculus
SH4-54 Colony formation assay Influence on cell viability 5.00 µM MEF/ST3KO Mus musculus
SH4-54 Tumor size Influence on tumor growth 6.00 mg/kg U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Tumor size Influence on tumor growth 6.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 3.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 4.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 5.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 3.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 4.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 5.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 3.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 4.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 5.00 µM U251MG (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 3.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 4.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 5.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 3.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 4.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 5.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 3.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 4.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Western Blot Influence on protein activity in tumor tissue 5.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice