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Experiments

Compound Investigated event Experiment type Concentration Cell line Organism Animal model Stat protein Details
SH4-54 Influence on protein binding to DNA EMSA 1.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH4-54 Influence on protein binding to DNA EMSA 3.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH4-54 Influence on protein binding to DNA EMSA 10.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH4-54 Influence on protein binding to DNA EMSA 5.00 µM MDA-MB-231 Homo sapiens STAT3:STAT3
SH4-54 Influence on protein activty Western Blot 1.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Influence on protein activty Western Blot 3.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Influence on protein activty Western Blot 10.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Influence on protein activty Western Blot 1.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Influence on protein activty Western Blot 3.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Influence on protein activty Western Blot 10.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Influence on protein activty Western Blot 5.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Influence on protein activty Western Blot 5.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Influence on proetin acivity in presnce of IL-6 Western Blot 10.00 µM MDA-MB-231 Homo sapiens p-STAT3(Y705)
SH4-54 Influence on proetin acivity in presnce of IL-6 Western Blot 10.00 µM MDA-MB-231 Homo sapiens STAT3
SH4-54 Influence on cell viability CyQUANT cell proliferation assay 2.00 µM MDA-MB-231 Homo sapiens
SH4-54 Influence on cell viability CyQUANT cell proliferation assay 4.00 µM MDA-MB-231 Homo sapiens
SH4-54 Influence on cell viability CyQUANT cell proliferation assay 6.00 µM MDA-MB-231 Homo sapiens
SH4-54 Influence on cell viability CyQUANT cell proliferation assay 8.00 µM MDA-MB-231 Homo sapiens
SH4-54 Influence on cell viability CyQUANT cell proliferation assay 10.00 µM MDA-MB-231 Homo sapiens
SH4-54 Influence on cell viability Colony formation assay 1.00 µM MDA-MB-231 Homo sapiens
SH4-54 Influence on cell viability Colony formation assay 3.00 µM MDA-MB-231 Homo sapiens
SH4-54 Influence on cell viability Colony formation assay 5.00 µM MDA-MB-231 Homo sapiens
SH4-54 Influence on tumor growth Tumor size 6.00 mg/kg MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 3.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 4.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 5.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 3.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 4.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 5.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 3.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 4.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice
SH4-54 Influence on protein activity in tumor tissue Western Blot 5.00 µM MDA-MB-231 (xenograft) Mus musculus athymic nude mice