Plumbagin

Name Value
Weight 188.182 g/mol
Zinc ID ZINC58187
Smiles CC1=CC(=O)c2c(O)cccc2C1=O
Molecular formula N/A
Mode of inhibition N/A
CAS 481-42-5

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer research Moammir H Aziz, Nancy E Dreckschmidt, Ajit K Verma, 68, 21, 2008-11-01, None, 10.1158/0008-5472.CAN-08-2494 10.1158/0008-5472.CAN-08-2494 18974148 PMC2584362

Vendors

Company Lnk to product
Tocris https://www.tocris.com/products/plumbagin_4761
Adooq https://www.adooq.com/plumbagin.html
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/sigma/p7262?lang=pl&region=PL
Chemfaces http://www.chemfaces.com/natural/Plumbagin-CFN90444.html
Selleckchem https://www.selleckchem.com/products/plumbagin.html
Santa Cruz Biotechnology https://www.scbt.com/p/plumbagin-481-42-5
Biovision https://www.biovision.com/plumbagin.html

Filter data

Compound Plumbagin
Experiment types EMSA, Flow cytometry- annexin V binding and propidium iodide staining, Immunohistochemistry, Invasion assay , Tumor volume, Tumor weight, Western Blot
Concentrations 10.00, 15.00, 2.00, 20.00, 5.00
Cell lines CWR22Rv1, DU145, DU145(xenograft), LNCaP, PC-3, RWPE-1
Organisms Homo sapiens, Mus musculus
Animal models athymic nude mice
STAT proteins STAT3, p-STAT3(S727), p-STAT3(Y705)
Other AKT, AP-1, Bcl-xL, Bcl-xS, COX-2, Cdc25A, Nf-κB, PCNA, PI3K(p110), PI3K(p85), PKCµ, PKCα, PKCβI, PKCβII, PKCγ, PKCδ, PKCε, PKCζ, PKCη, p-AKT(T308), p-JAK1(Y1022/10230, p-JAK2(Y1007/1008), p21, p27, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 5.00 µM DU145 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 10.00 µM DU145 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 15.00 µM DU145 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 5.00 µM RWPE-1 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 10.00 µM RWPE-1 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 15.00 µM RWPE-1 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 5.00 µM CWR22Rv1 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 10.00 µM CWR22Rv1 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 15.00 µM CWR22Rv1 Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 5.00 µM LNCaP Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 10.00 µM LNCaP Homo sapiens
Plumbagin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell apoptosis 15.00 µM LNCaP Homo sapiens
Plumbagin Invasion assay Influence on cell motility 5.00 µM DU145 Homo sapiens
Plumbagin Invasion assay Influence on cell motility 20.00 µM DU145 Homo sapiens
Plumbagin Invasion assay Influence on cell motility 5.00 µM CWR22Rv1 Homo sapiens
Plumbagin Invasion assay Influence on cell motility 20.00 µM CWR22Rv1 Homo sapiens
Plumbagin Invasion assay Influence on cell motility 5.00 µM PC-3 Homo sapiens
Plumbagin Invasion assay Influence on cell motility 20.00 µM PC-3 Homo sapiens
Plumbagin Tumor weight Influence on cell proliferation in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Tumor volume Influence on cell proliferation in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Immunohistochemistry Influence on cell proliferation in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice STAT3
Plumbagin Immunohistochemistry Influence on cell proliferation in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Immunohistochemistry Influence on cell proliferation in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens p-STAT3(Y705)
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens p-STAT3(Y705)
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens p-STAT3(Y705)
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens p-STAT3(S727)
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens p-STAT3(S727)
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens p-STAT3(S727)
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens STAT3
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens STAT3
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens STAT3
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice p-STAT3(Y705)
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice p-STAT3(S727)
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice STAT3
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin Western Blot Influence on protein activity in tumor tissue 2.00 mg/kg DU145(xenograft) Mus musculus athymic nude mice
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM DU145 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM DU145 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM DU145 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM DU145 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM DU145 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM DU145 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM DU145 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM DU145 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM DU145 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM DU145 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM DU145 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM DU145 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM CWR22Rv1 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM CWR22Rv1 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM CWR22Rv1 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM CWR22Rv1 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM CWR22Rv1 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM CWR22Rv1 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM CWR22Rv1 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM CWR22Rv1 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM CWR22Rv1 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM CWR22Rv1 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM CWR22Rv1 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM CWR22Rv1 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM PC-3 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM PC-3 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM PC-3 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM PC-3 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM PC-3 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM PC-3 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM PC-3 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM PC-3 Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM PC-3 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM PC-3 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM PC-3 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM PC-3 Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM LNCaP Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM LNCaP Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM LNCaP Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM LNCaP Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM LNCaP Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM LNCaP Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM LNCaP Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM LNCaP Homo sapiens
Plumbagin EMSA Influence on protein-DNA interaction 5.00 µM LNCaP Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 10.00 µM LNCaP Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 15.00 µM LNCaP Homo sapiens STAT3
Plumbagin EMSA Influence on protein-DNA interaction 20.00 µM LNCaP Homo sapiens STAT3
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 5.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 10.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 15.00 µM DU145 Homo sapiens
Plumbagin Western Blot Influence on protein activity 20.00 µM DU145 Homo sapiens