Linderalactone

Name Value
Weight 244.290 g/mol
Zinc ID ZINC13532008
Smiles C/C1=C\CCC2=C[C@@H](OC2=O)c2c(C)coc2C1
Molecular formula C15H16O3
Mode of inhibition N/A
CAS 728-61-0

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins, G2/M cell cycle arrest and inhibition of JAK/STAT signalling pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology Yanglin Deng, Ya Li, 24, 2, None, None, N/A N/A 31128007 31128007

Vendors

Company Lnk to product
MedChemExpress https://www.medchemexpress.com/linderalactone.html
ChemFaces https://www.chemfaces.com/natural/Linderalactone-CFN99761.html
APExBIO https://www.apexbt.com/linderalactone.html
Selleckchem https://www.selleckchem.com/products/linderalactone.html

Filter data

Compound Linderalactone
Experiment types DAPI staining , Flow cytometry Annexin V-FITC, MTT, Western Blot
Concentrations 1.60, 100.00, 12.50, 15.00, 25.00, 3.20, 30.00, 50.00, 6.25, 7.50
Cell lines A549
Organisms Homo sapiens
Animal models
STAT proteins STAT1, STAT2, p-STAT1, p-STAT2
Other Actin , Bax, Bcl-2, Caspase-3, Caspase-9, Cyt-C, JAK1, JAK2, p-JAK1, p-JAK2

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Linderalactone MTT Influence on cell viability 1.60 µM A549 Homo sapiens
Linderalactone MTT Influence on cell viability 3.20 µM A549 Homo sapiens
Linderalactone MTT Influence on cell viability 6.25 µM A549 Homo sapiens
Linderalactone MTT Influence on cell viability 12.50 µM A549 Homo sapiens
Linderalactone MTT Influence on cell viability 25.00 µM A549 Homo sapiens
Linderalactone MTT Influence on cell viability 50.00 µM A549 Homo sapiens
Linderalactone MTT Influence on cell viability 100.00 µM A549 Homo sapiens
Linderalactone Flow cytometry Annexin V-FITC Influence on cell apoptosis 7.50 µM A549 Homo sapiens
Linderalactone Flow cytometry Annexin V-FITC Influence on cell apoptosis 15.00 µM A549 Homo sapiens
Linderalactone Flow cytometry Annexin V-FITC Influence on cell apoptosis 30.00 µM A549 Homo sapiens
Linderalactone DAPI staining Influence on cell apoptosis 7.50 µM A549 Homo sapiens
Linderalactone DAPI staining Influence on cell apoptosis 15.00 µM A549 Homo sapiens
Linderalactone DAPI staining Influence on cell apoptosis 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on cell cycle 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens STAT1
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens STAT1
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens p-STAT1
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens p-STAT1
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens p-STAT1
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens STAT2
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens STAT2
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens STAT2
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens p-STAT2
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens p-STAT2
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens p-STAT2
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 7.50 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 15.00 µM A549 Homo sapiens
Linderalactone Western Blot Influence on protein activity 30.00 µM A549 Homo sapiens