Fraxetin

Name Value
Weight 208.169 g/mol
Zinc ID ZINC113309
Smiles COc1cc2ccc(=O)oc2c(O)c1O
Molecular formula C10H8O5
Mode of inhibition N/A
CAS 574-84-5

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway. The international journal of biochemistry & cell biology Shuo Ren, Yanwei Xing, Chengbo Wang, Fengqi Jiang, Guangyu Liu, Ziyi Li, Tao Jiang, Yuekun Zhu, Daxun Piao, 125, None, None, 2020-06-03, 10.1016/j.biocel.2020.105777 10.1016/j.biocel.2020.105777 32504672 32504672

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/fraxetin.html
MERCK/Sigma Aldrich https://www.sigmaaldrich.com/PL/pl/substance/fraxetin20817574845

Filter data

Compound Fraxetin
Experiment types Average mice weight, CCK8 assay, Colony formation assay , Flow cytometry- annexin V binding and propidium iodide staining, Immunohistochemistry, RT-qPCR, Tumor volume, Tumor weight, Western Blot
Concentrations 100.00, 120.00, 20.00, 40.00, 60.00, 80.00
Cell lines COAD, COAD (xenograft), DLD-1, HCT116, HCT116 (xenograft), NCM460
Organisms Homo sapiens, Mus musculus
Animal models BALB/c
STAT proteins STAT3, p-STAT3
Other BAX, Bcl-2, CDK2, Cleaved PARP, Cyclin A2, Cyclin E1, JAK2, Ki67, PARP, Skp2, p-JAK2, p27, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Fraxetin CCK8 assay Influence on cell apoptosis 20.00 µM HCT116 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 40.00 µM HCT116 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 60.00 µM HCT116 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 80.00 µM HCT116 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 100.00 µM HCT116 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 120.00 µM HCT116 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 20.00 µM DLD-1 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 40.00 µM DLD-1 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 60.00 µM DLD-1 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 80.00 µM DLD-1 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 100.00 µM DLD-1 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 120.00 µM DLD-1 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 20.00 µM NCM460 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 40.00 µM NCM460 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 60.00 µM NCM460 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 80.00 µM NCM460 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 100.00 µM NCM460 Homo sapiens
Fraxetin CCK8 assay Influence on cell apoptosis 120.00 µM NCM460 Homo sapiens
Fraxetin Colony formation assay Influence on cell proliferation 20.00 µM HCT116 Homo sapiens
Fraxetin Colony formation assay Influence on cell proliferation 40.00 µM HCT116 Homo sapiens
Fraxetin Colony formation assay Influence on cell proliferation 60.00 µM HCT116 Homo sapiens
Fraxetin Colony formation assay Influence on cell proliferation 80.00 µM HCT116 Homo sapiens
Fraxetin Colony formation assay Influence on cell proliferation 20.00 µM DLD-1 Homo sapiens
Fraxetin Colony formation assay Influence on cell proliferation 40.00 µM DLD-1 Homo sapiens
Fraxetin Colony formation assay Influence on cell proliferation 60.00 µM DLD-1 Homo sapiens
Fraxetin Colony formation assay Influence on cell proliferation 80.00 µM DLD-1 Homo sapiens
Fraxetin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycle 20.00 µM COAD Homo sapiens
Fraxetin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycle 40.00 µM COAD Homo sapiens
Fraxetin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycle 60.00 µM COAD Homo sapiens
Fraxetin Flow cytometry- annexin V binding and propidium iodide staining Influence on cell cycle 80.00 µM COAD Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell cycle 80.00 µM DLD-1 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 20.00 µM HCT116 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 40.00 µM HCT116 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 60.00 µM HCT116 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 20.00 µM DLD-1 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 40.00 µM DLD-1 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 60.00 µM DLD-1 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 20.00 µM HCT116 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 40.00 µM HCT116 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 60.00 µM HCT116 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 20.00 µM DLD-1 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 40.00 µM DLD-1 Homo sapiens
Fraxetin RT-qPCR Influence on cell apoptosis 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on cell apoptosis 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 80.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 20.00 µM HCT116 Homo sapiens STAT3
Fraxetin Western Blot Influence on protein activity 40.00 µM HCT116 Homo sapiens STAT3
Fraxetin Western Blot Influence on protein activity 60.00 µM HCT116 Homo sapiens STAT3
Fraxetin Western Blot Influence on protein activity 80.00 µM HCT116 Homo sapiens STAT3
Fraxetin Western Blot Influence on protein activity 20.00 µM DLD-1 Homo sapiens STAT3
Fraxetin Western Blot Influence on protein activity 40.00 µM DLD-1 Homo sapiens STAT3
Fraxetin Western Blot Influence on protein activity 60.00 µM DLD-1 Homo sapiens STAT3
Fraxetin Western Blot Influence on protein activity 80.00 µM DLD-1 Homo sapiens STAT3
Fraxetin Western Blot Influence on protein activity 20.00 µM HCT116 Homo sapiens p-STAT3
Fraxetin Western Blot Influence on protein activity 40.00 µM HCT116 Homo sapiens p-STAT3
Fraxetin Western Blot Influence on protein activity 60.00 µM HCT116 Homo sapiens p-STAT3
Fraxetin Western Blot Influence on protein activity 80.00 µM HCT116 Homo sapiens p-STAT3
Fraxetin Western Blot Influence on protein activity 20.00 µM DLD-1 Homo sapiens p-STAT3
Fraxetin Western Blot Influence on protein activity 40.00 µM DLD-1 Homo sapiens p-STAT3
Fraxetin Western Blot Influence on protein activity 60.00 µM DLD-1 Homo sapiens p-STAT3
Fraxetin Western Blot Influence on protein activity 80.00 µM DLD-1 Homo sapiens p-STAT3
Fraxetin Western Blot Influence on protein activity 20.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 40.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 60.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 80.00 µM HCT116 Homo sapiens
Fraxetin Western Blot Influence on protein activity 20.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 40.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 60.00 µM DLD-1 Homo sapiens
Fraxetin Western Blot Influence on protein activity 80.00 µM DLD-1 Homo sapiens
Fraxetin Average mice weight Influence on cell proliferation in tumor tissue 20.00 mg/kg HCT116 (xenograft) Mus musculus BALB/c
Fraxetin Tumor volume Influence on cell proliferation in tumor tissue 20.00 mg/kg HCT116 (xenograft) Mus musculus BALB/c
Fraxetin Tumor weight Influence on cell proliferation in tumor tissue 20.00 mg/kg HCT116 (xenograft) Mus musculus BALB/c
Fraxetin Immunohistochemistry Influence on cell proliferation in tumor tissue 20.00 mg/kg HCT116 (xenograft) Mus musculus BALB/c
Fraxetin Immunohistochemistry Influence on cell proliferation in tumor tissue 20.00 mg/kg HCT116 (xenograft) Mus musculus BALB/c
Fraxetin Immunohistochemistry Influence on cell proliferation in tumor tissue 20.00 mg/kg HCT116 (xenograft) Mus musculus BALB/c p-STAT3
Fraxetin Immunohistochemistry Influence on cell proliferation in tumor tissue 20.00 mg/kg HCT116 (xenograft) Mus musculus BALB/c
Fraxetin Immunohistochemistry Influence on cell proliferation in tumor tissue 20.00 mg/kg HCT116 (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c
Fraxetin Western Blot Influence on protein activity in tumor tissue 20.00 mg/kg COAD (xenograft) Mus musculus BALB/c