Falcarindiol

Name Value
Weight 260.377 g/mol
Zinc ID ZINC8214562
Smiles C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC
Molecular formula C17H24O2
Mode of inhibition N/A
CAS 225110-25-8

Clinical Trials

Study title Status Conditions Link
The Effects of Foods on Cell Damage Study Completed DNA Damage|Inflammation NCT02696811
The Bioavailability of Polyacetylenes From Carrots Study Completed Healthy NCT02696473

References

Publication DOI Pubmed PMCID
Falcarindiol inhibits LPS-induced inflammation via attenuating MAPK and JAK-STAT signaling pathways in murine macrophage RAW 264.7 cells. Molecular and cellular biochemistry Thamizhiniyan Venkatesan, Young-Woong Choi, Jennifer Lee, Young-Kyoon Kim, 445, 1-2, None, 2018-01-24, 10.1007/s11010-017-3262-z 10.1007/s11010-017-3262-z 29368095 29368095

Vendors

Company Lnk to product
Selleckchem https://www.selleckchem.com/products/falcarindiol.html

Filter data

Compound Falcarindiol
Experiment types DAF-FM DA, Griess reaction, MTT, RT-qPCR, Western Blot
Concentrations 10.00, 15.00, 20.00, 25.00, 5.00
Cell lines RAW 264.7
Organisms Homo sapiens
Animal models
STAT proteins
Other Actin, Actin (cytosolic), ERK, IL-6, IκB, JNK, Lamin B (nuclear), NFκB (cytosolic), NFκB (nuclear), TNFα, iNOS, p-ERK, p-JNK, p-p38, p38

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Falcarindiol MTT Influence on cell viability 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol MTT Influence on cell viability 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol MTT Influence on cell viability 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol MTT Influence on cell viability 20.00 µM RAW 264.7 Homo sapiens
Falcarindiol MTT Influence on cell viability 25.00 µM RAW 264.7 Homo sapiens
Falcarindiol Griess reaction Influence on NO production in presence of LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Griess reaction Influence on NO production in presence of LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Griess reaction Influence on NO production in presence of LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Griess reaction Influence on NO production in presence of LPS 20.00 µM RAW 264.7 Homo sapiens
Falcarindiol DAF-FM DA Influence on intracellular NO production in presence of LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol DAF-FM DA Influence on intracellular NO production in presence of LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol DAF-FM DA Influence on intracellular NO production in presence of LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol DAF-FM DA Influence on intracellular NO production in presence of LPS 20.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol RT-qPCR Influence on gene expression in presence of LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on protein activity in presence of LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on protein activity in presence of LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on protein activity in presence of LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on protein activity in presence of LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on protein activity in presence of LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on protein activity in presence of LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in LPS 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 15.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 5.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 10.00 µM RAW 264.7 Homo sapiens
Falcarindiol Western Blot Influence on MAPK pathway in NFκB 15.00 µM RAW 264.7 Homo sapiens