Evodiamine

Name Value
Weight 303.365 g/mol
Zinc ID ZINC2031813
Smiles CN1c2ccccc2C(=O)N2CCc3c([nH]c4ccccc34)[C@@H]21
Molecular formula C19H17N3O
Mode of inhibition JAK2, SHP1, STAT; Natural product
CAS 518-17-2

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells. Cancer letters Jie Yang, Xueting Cai, Wuguang Lu, Chunping Hu, Xiaojun Xu, Qiang Yu, Peng Cao, 328, 2, 2013-01-28, 2012-09-29, 10.1016/j.canlet.2012.09.019 10.1016/j.canlet.2012.09.019 23032719 23032719

Vendors

Company Lnk to product
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/sigma/e3531?lang=pl&region=PL
Caymanchemical https://www.caymanchem.com/product/16885/(%2B)-evodiamine
Selleckchem https://www.selleckchem.com/products/Evodiamine(Isoevodiamine).html
Parchem https://www.parchem.com/chemical-supplier-distributor/Evodiamine-007894.aspx
ChemFaces http://www.chemfaces.com/natural/Evodiamine-CFN99993.html

Filter data

Compound Evodiamine
Experiment types EMSA, Flow cytometry , Immunohistochemistry, MTT, RT-PCR, RT-qPCR, Tumor volume, Tumor weight, Western Blot
Concentrations 10.00, 100.00, 12.50, 20.00, 25.00, 30.00, 5.00, 50.00
Cell lines Bcl-7402, Bel-7402, HCC, Hep2, Hep2 (xenograft), LO-2, QGY-7701
Organisms Homo sapiens, Mus musculus
Animal models
STAT proteins SHP-1, STAT3, p-STAT3, p-STAT3 (Tyr705)
Other AKT, Bcl-2, COX-2, Cleaved caspase-8, Cyclin D1, ERK1/2, GAPDH, HIFI-α, MMP-9, Mcl-1, PARP, SHP-1, SHP-2, Src, Survivin, VEGF, XIAP, p-AKT, p-ERK1/2, p-JAK2, p-Src

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Evodiamine Western Blot Influence on protein activity in presence of IL6 5.00 µM HCC Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 25.00 µM HCC Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM HCC Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 5.00 µM HCC Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 25.00 µM HCC Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM HCC Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 5.00 µM HCC Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 25.00 µM HCC Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM HCC Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 5.00 µM Hep2 Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 25.00 µM Hep2 Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM Hep2 Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 5.00 µM Hep2 Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 25.00 µM Hep2 Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM Hep2 Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM QGY-7701 Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM QGY-7701 Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM Bel-7402 Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM Bel-7402 Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM Bel-7402 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in presence of IL6 50.00 µM Hep2 Homo sapiens
Evodiamine RT-PCR Influence on RNA expression 5.00 µM Hep2 Homo sapiens
Evodiamine RT-PCR Influence on RNA expression 25.00 µM Hep2 Homo sapiens
Evodiamine RT-PCR Influence on RNA expression 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on protein activity in transfected cells upon presence of IL6 50.00 µM Hep2 Homo sapiens p-STAT3
Evodiamine Western Blot Influence on protein activity in transfected cells upon presence of IL6 50.00 µM Hep2 Homo sapiens STAT3
Evodiamine Western Blot Influence on protein activity in transfected cells upon presence of IL6 50.00 µM Hep2 Homo sapiens SHP-1
Evodiamine Western Blot Influence on protein activity in transfected cells upon presence of IL6 50.00 µM Hep2 Homo sapiens
Evodiamine EMSA Influence on STAT3 signalling 50.00 µM QGY-7701 Homo sapiens
Evodiamine EMSA Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 30.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 30.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 30.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 30.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 30.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on STAT3 signalling 50.00 µM Hep2 Homo sapiens
Evodiamine Flow cytometry Influence on cell cycle 5.00 µM Hep2 Homo sapiens
Evodiamine Flow cytometry Influence on cell cycle 25.00 µM Hep2 Homo sapiens
Evodiamine Flow cytometry Influence on cell cycle 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM Hep2 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM Bcl-7402 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 5.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 25.00 µM QGY-7701 Homo sapiens
Evodiamine Western Blot Influence on cell cycle 50.00 µM QGY-7701 Homo sapiens
Evodiamine MTT Influence on cell viability 12.50 µM Hep2 Homo sapiens
Evodiamine MTT Influence on cell viability 25.00 µM Hep2 Homo sapiens
Evodiamine MTT Influence on cell viability 50.00 µM Hep2 Homo sapiens
Evodiamine MTT Influence on cell viability 100.00 µM Hep2 Homo sapiens
Evodiamine MTT Influence on cell viability 12.50 µM LO-2 Homo sapiens
Evodiamine MTT Influence on cell viability 25.00 µM LO-2 Homo sapiens
Evodiamine MTT Influence on cell viability 50.00 µM LO-2 Homo sapiens
Evodiamine MTT Influence on cell viability 100.00 µM LO-2 Homo sapiens
Evodiamine Tumor volume Influence on tumor growth 10.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine Tumor volume Influence on tumor growth 20.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine Tumor weight Influence on tumor growth 10.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine Tumor weight Influence on tumor growth 20.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine Immunohistochemistry Influence on tumor growth 10.00 mg/kg Hep2 (xenograft) Mus musculus p-STAT3 (Tyr705)
Evodiamine Immunohistochemistry Influence on tumor growth 20.00 mg/kg Hep2 (xenograft) Mus musculus p-STAT3 (Tyr705)
Evodiamine Immunohistochemistry Influence on tumor growth 10.00 mg/kg Hep2 (xenograft) Mus musculus STAT3
Evodiamine Immunohistochemistry Influence on tumor growth 20.00 mg/kg Hep2 (xenograft) Mus musculus STAT3
Evodiamine RT-qPCR Influence on tumor growth 10.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine RT-qPCR Influence on tumor growth 20.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine RT-qPCR Influence on tumor growth 10.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine RT-qPCR Influence on tumor growth 20.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine RT-qPCR Influence on tumor growth 10.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine RT-qPCR Influence on tumor growth 20.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine RT-qPCR Influence on tumor growth 10.00 mg/kg Hep2 (xenograft) Mus musculus
Evodiamine RT-qPCR Influence on tumor growth 20.00 mg/kg Hep2 (xenograft) Mus musculus