Ergosterol peroxide

Name Value
Weight 396.659 g/mol
Zinc ID ZINC4629876
Smiles C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)/C=C/[C@H](C)C(C)C
Molecular formula C28H44O
Mode of inhibition JAK, SRC, STAT; Natural product
CAS 2061-64-5

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
Identification of Escherichia coli from shellfish and related environments by automicrobic system. Journal - Association of Official Analytical Chemists J L Tardió, K O'Brien, T Latt, 71, 3, None, None, 10.1186/1471-2407-12-28 10.1186/1471-2407-12-28 3292511 22260501
Ergosterol peroxide inhibits ovarian cancer cell growth through multiple pathways. OncoTargets and therapy Weiwei Tan, Meihong Pan, Hui Liu, Hequn Tian, Qing Ye, Hongda Liu, 10, None, None, 2017-07-13, 10.2147/OTT.S139009 10.2147/OTT.S139009 28761355 PMC5518915

Vendors

Company Lnk to product
CarboSynth https://www.carbosynth.com/carbosynth/website.nsf/(w-productdisplay)/5F8C1E0C2DEF517780257C460079AA4F
Sigma Aldrich https://www.sigmaaldrich.com/catalog/product/sigma/45480?lang=pl&region=PL

Filter data

Compound Ergosterol peroxide
Experiment types Body weight, ELISA, EMSA, Immunostaining , MTT, PrestoBlue™ Cell Viability Assay , RT-PCR, RT-qPCR, Tube formation assay , Tumor volume, Western Blot, Wound healing assay
Concentrations 100.00, 12.50, 25.00, 50.00, 6.25, 75.00
Cell lines CAOV3, DU145, HOC-7, HUVEC, MDA-MB231, MPSC-1, OSE, OVCAR-3, SCC4, U266, U266(xenograft)
Organisms Homo sapiens, Mus musculus
Animal models BALB/c
STAT proteins STAT3, STAT3 (nuclear), p-STAT3
Other CD34, Cyclin D1, JAK2, Nuclear β-catenin, SHP-1, SHP2, Src, VEGF-C, c-Myc, p-JAK2, p-Src, β-actin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM U266 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM U266 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 6.25 µM U266 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 12.50 µM U266 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 6.25 µM U266 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 12.50 µM U266 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM SCC4 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM SCC4 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM DU145 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM DU145 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM MDA-MB231 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM MDA-MB231 Homo sapiens STAT3
Ergosterol peroxide EMSA Influence on protein binding affinity to DNA 6.25 µM U266 Homo sapiens STAT3 (nuclear)
Ergosterol peroxide EMSA Influence on protein binding affinity to DNA 12.50 µM U266 Homo sapiens STAT3 (nuclear)
Ergosterol peroxide EMSA Influence on protein binding affinity to DNA 25.00 µM U266 Homo sapiens STAT3 (nuclear)
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 6.25 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 12.50 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 6.25 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in cells 12.50 µM U266 Homo sapiens
Ergosterol peroxide RT-PCR Influence on protein acticity in cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in transfected cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide Western Blot Influence on protein acticity in transfected cells 25.00 µM U266 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in transfected cells 25.00 µM U266 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on protein acticity in transfected cells 25.00 µM U266 Homo sapiens
Ergosterol peroxide MTT Influence on cell viability 25.00 µM U266 Homo sapiens
Ergosterol peroxide MTT Influence on cell viability 12.50 µM U266 Homo sapiens
Ergosterol peroxide MTT Influence on cell viability 6.25 µM U266 Homo sapiens
Ergosterol peroxide MTT Influence on cell viability 50.00 µM U266 Homo sapiens
Ergosterol peroxide ELISA Influence on cell viability 6.25 µM U266 Homo sapiens
Ergosterol peroxide ELISA Influence on cell viability 12.50 µM U266 Homo sapiens
Ergosterol peroxide ELISA Influence on cell viability 25.00 µM U266 Homo sapiens
Ergosterol peroxide Tube formation assay Influence on cell viability 12.50 µM HUVEC Homo sapiens
Ergosterol peroxide Tube formation assay Influence on cell viability 25.00 µM HUVEC Homo sapiens
Ergosterol peroxide Western Blot Influence on protein activity in presence of VEGF 25.00 µM HUVEC Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on protein activity in presence of VEGF 25.00 µM HUVEC Homo sapiens STAT3
Ergosterol peroxide Tumor volume Influence o tumor growth 100.00 mg/kg U266(xenograft) Mus musculus BALB/c
Ergosterol peroxide Body weight Influence o tumor growth 100.00 mg/kg U266(xenograft) Mus musculus BALB/c
Ergosterol peroxide Immunostaining Influence o tumor growth 100.00 mg/kg U266(xenograft) Mus musculus BALB/c
Ergosterol peroxide Immunostaining Influence o tumor growth 100.00 mg/kg U266(xenograft) Mus musculus BALB/c p-STAT3
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 25.00 µM OSE Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 50.00 µM OSE Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 75.00 µM OSE Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 100.00 µM OSE Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 25.00 µM CAOV3 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 75.00 µM CAOV3 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 100.00 µM CAOV3 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 25.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 75.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 100.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 25.00 µM HOC-7 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 75.00 µM HOC-7 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 100.00 µM HOC-7 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 25.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 75.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide PrestoBlue™ Cell Viability Assay Influence on cell viability and proliferation 100.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide Wound healing assay Influence on cell migration 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide Wound healing assay Influence on cell migration 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide Wound healing assay Influence on cell migration 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide Wound healing assay Influence on cell migration 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM CAOV3 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM CAOV3 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM MPSC-1 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM MPSC-1 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM HOC-7 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM HOC-7 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM OVCAR-3 Homo sapiens p-STAT3
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM OVCAR-3 Homo sapiens STAT3
Ergosterol peroxide Western Blot Influence on oncogenic proteins 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide RT-qPCR Influence on RNA expression 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide RT-qPCR Influence on RNA expression 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide RT-qPCR Influence on RNA expression 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide RT-qPCR Influence on RNA expression 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide RT-qPCR Influence on RNA expression 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide RT-qPCR Influence on RNA expression 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide RT-qPCR Influence on RNA expression 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide RT-qPCR Influence on RNA expression 50.00 µM OVCAR-3 Homo sapiens
Ergosterol peroxide ELISA Influence on RNA expression 50.00 µM CAOV3 Homo sapiens
Ergosterol peroxide ELISA Influence on RNA expression 50.00 µM MPSC-1 Homo sapiens
Ergosterol peroxide ELISA Influence on RNA expression 50.00 µM HOC-7 Homo sapiens
Ergosterol peroxide ELISA Influence on RNA expression 50.00 µM OVCAR-3 Homo sapiens