CPA-7

Name Value
Weight 0.000 g/mol
Zinc ID N/A
Smiles N/A
Molecular formula N/A
Mode of inhibition Direct STAT; targetting DBD
CAS N/A

Clinical Trials

Study title Status Conditions Link

References

Publication DOI Pubmed PMCID
CPA-7 influences immune profile and elicits anti-prostate cancer effects by inhibiting activated STAT3. BMC cancer Meihua Liang, Fei Zhan, Juan Zhao, Qi Li, Jiazi Wuyang, Guannan Mu, Dianjun Li, Yanqiao Zhang, Xiaoyi Huang, 16, None, 2016-07-19, 2016-07-19, 10.1186/s12885-016-2488-6 10.1186/s12885-016-2488-6 27435207 PMC4952363

Filter data

Compound CPA-7
Experiment types Average survival, Body weight, Cell counting , Kaplan Meier recurence , Luciferase activity, Precentage of STAT3 cells, Tumor size , Western Blot
Concentrations 0.75, 1.50, 10.00, 20.00, 3.00, 5.00
Cell lines RM-9
Organisms Mus musculus
Animal models
STAT proteins STAT3, p-STAT3 (Y705)
Other Bcl-xL, β-tubulin

Experiments

Compound Experiment type Investigated event Concentration Cell line Organism Animal model Stat protein Details
CPA-7 Body weight Influence on tumor growth 0.75 mg/kg RM-9 Mus musculus
CPA-7 Body weight Influence on tumor growth 1.50 mg/kg RM-9 Mus musculus
CPA-7 Body weight Influence on tumor growth 3.00 mg/kg RM-9 Mus musculus
CPA-7 Cell counting Influence on tumor growth 5.00 µM RM-9 Mus musculus
CPA-7 Cell counting Influence on tumor growth 10.00 µM RM-9 Mus musculus
CPA-7 Cell counting Influence on tumor growth 20.00 µM RM-9 Mus musculus
CPA-7 Tumor size Influence on tumor growth 0.75 mg/kg RM-9 Mus musculus
CPA-7 Tumor size Influence on tumor growth 1.50 mg/kg RM-9 Mus musculus
CPA-7 Kaplan Meier recurence Influence on tumor growth 0.75 mg/kg RM-9 Mus musculus
CPA-7 Kaplan Meier recurence Influence on tumor growth 1.50 mg/kg RM-9 Mus musculus
CPA-7 Average survival Influence on tumor growth 0.75 mg/kg RM-9 Mus musculus
CPA-7 Average survival Influence on tumor growth 1.50 mg/kg RM-9 Mus musculus
CPA-7 Western Blot Influence on protein activity 10.00 µM RM-9 Mus musculus STAT3
CPA-7 Western Blot Influence on protein activity 10.00 µM RM-9 Mus musculus p-STAT3 (Y705)
CPA-7 Western Blot Influence on protein activity 10.00 µM RM-9 Mus musculus
CPA-7 Western Blot Influence on protein activity 10.00 µM RM-9 Mus musculus
CPA-7 Luciferase activity Influence on protein activity 5.00 µM RM-9 Mus musculus
CPA-7 Luciferase activity Influence on protein activity 10.00 µM RM-9 Mus musculus
CPA-7 Precentage of STAT3 cells Influence on protein activity 0.75 mg/kg RM-9 Mus musculus
CPA-7 Precentage of STAT3 cells Influence on protein activity 1.50 mg/kg RM-9 Mus musculus